Prof. Alexander P. Savitsky
at AN Bach Institute of Biochemistry
SPIE Involvement:
Conference Program Committee | Conference Chair | Author | Instructor
Publications (52)

PROCEEDINGS ARTICLE | March 14, 2018
Proc. SPIE. 10498, Multiphoton Microscopy in the Biomedical Sciences XVIII
KEYWORDS: Proteins, Tumors, Visualization, Scanners, In vivo imaging, Fluorescent proteins

SPIE Journal Paper | March 2, 2018
JBO Vol. 23 Issue 03
KEYWORDS: Tumors, Luminescence, Sensors, Fluorescence lifetime imaging, In vivo imaging, Picosecond phenomena, Cell death, Fluorescence resonance energy transfer, Confocal microscopy, Visualization

PROCEEDINGS ARTICLE | February 22, 2013
Proc. SPIE. 8590, Single Molecule Spectroscopy and Superresolution Imaging VI
KEYWORDS: Proteins, Sensors, Luminescence, Quantum efficiency, Biosensors, 3D modeling, Resonance energy transfer, Fluorescent proteins, Fluorescence resonance energy transfer, Molecular energy transfer

PROCEEDINGS ARTICLE | April 12, 2011
Proc. SPIE. 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII
KEYWORDS: Liver, Tissues, Luminescence, Fluorescence spectroscopy, Coating, Quantum dots, Lung, Spleen, Kidney, In vivo imaging

PROCEEDINGS ARTICLE | February 12, 2011
Proc. SPIE. 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
KEYWORDS: Proteins, Biomedical optics, Green fluorescent protein, Chemical species, Molecules, Crystals, Chromophores, Fluorescent proteins, Systems modeling, Absorption

PROCEEDINGS ARTICLE | November 25, 2010
Proc. SPIE. 7376, Laser Applications in Life Sciences
KEYWORDS: Proteins, Luminescence, Image resolution, Computer programming, Biochemistry, Dynamic light scattering, Fluorescence lifetime imaging, Fluorescent proteins, Fluorescence resonance energy transfer, In vitro testing

Showing 5 of 52 publications
Conference Committee Involvement (12)
Laser Applications in Life Sciences
9 June 2010 | Oulu, Finland
Fluorescence In Vivo Imaging Based on Genetically Engineered Probes: From Living Cells to Whole Body Imaging IV
25 January 2009 | San Jose, California, United States
Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes
21 January 2008 | San Jose, California, United States
Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes
23 January 2007 | San Jose, California, United States
Genetically Engineered Probes for Biomedical Applications
24 January 2006 | San Jose, California, United States
Showing 5 of 12 published special sections
Course Instructor
SC039: Basic Principles of Microsecond Time-Resolved Photoluminescent Labeling Technology
Microsecond time-resolved photoluminescent labels are being used increasingly in immuno and DNA assays and diagnostics, biosensors and microbiochip, liquid chromatography and electrophoresis, microscopy, as well as drug detection and drug discover, cytotoxicity measurements (Eu-release), ecology, fingerprint detection, and long distance measurements in biological systems. Numerous and growing numbers of lanthanide chelates, room temperature phosphorescent labels provide dramatic improvements in sensitivity of assays, efficient background signal rejection, real-time measurements, high throughput screening, homogeneous and nonseparation formats of assays.
SC695: Optical in vivo Biosensing Based on Color Fluorescent Proteins
This course provides attendees with a basic working knowledge of fluorescent in vivo biosensors. Green fluorescent protein (GFP) was only the first of many types used for in vivo biosensing. Novel fluorescent proteins (nFP) from different sources comprise a rapidly growing arsenal of gene-based optical probes for numerous applications in biology, biotechnology, and medicine. This course concentrates <b>First</b>, on the systematization and classification of different nFP and major photophysical and chemical features of nFP. <b>Second</b>, on the principles of operation of molecular biosensors with fluorescent detection in living cells and animals. <b>Third</b>, on the application of nFP for drug design and screening. A survey of available genetic constructions and optical systems used for microscopic fluorescence detection as well as small animal whole-body imaging are included throughout the course.
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