Dr. Alexey Bocharnikov Profile

Dr. Alexey Bocharnikov

at art photonics GmbH

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Author

Publications (8)

Proceedings Article | 13 March 2024 Presentation

Advanced fiber spectroscopy for industrial process control and biomedical diagnostics

Viacheslav Artyushenko, A. Bocharnikov, A. Novikov, M. Yusuf, W. Gries, M. Warman, E. Feliksberger

Proceedings Volume PC12835, PC128350K (2024) https://doi.org/10.1117/12.3002938

KEYWORDS: Spectroscopy, Raman spectroscopy, Fiber optics, Diagnostics, Biomedical optics, Advanced process control, Mid-IR, Biomedical applications, Near infrared spectroscopy, Microwave radiation

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Proceedings Article | 6 March 2023 Presentation

Advances in multispectral fiber sensing for biomedical applications (Conference Presentation)

Alexander Novikov, Iskander Usenov, Andrey Bogomolov, Tatiana Sakharova, Alexey Bocharnikov, Viacheslav Artyushenko

Proceedings Volume PC12372, PC123720C (2023) https://doi.org/10.1117/12.2650615

KEYWORDS: Biomedical optics, Spectroscopy, Raman spectroscopy, Fiber optics, Biosensing, Tissues, Tissue optics, Near infrared, Luminescence, Fluorescence spectroscopy

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Proceedings Article | 30 May 2022 Presentation

Fiber sensors with multispectral approach for biomedical and industrial applications

Iskander Usenov, Tatiana Sakharova, Alexander Novikov, Andrey Bogomolov, Alexey Bocharnikov, Viacheslav Artyushenko

Proceedings Volume PC12139, PC121390I (2022) https://doi.org/10.1117/12.2624472

KEYWORDS: Chemical analysis, Raman spectroscopy, Biomedical optics, Spectroscopy, Fiber optics sensors, Fiber optics, Biological research, Statistical analysis, Attenuated total reflectance, Process control

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Fiber optic spectroscopy label-free composition analysis makes it the best tool for reaction monitoring in Process Analytical Technologies (PAT) and chemical analysis of bio tissues for medical diagnostics in-citu and in-vivo. Biological samples and modern chemicals are complex substances, which composition analysis requires combining several spectroscopic techniques. Fiber optics probes provide compact, flexible, robust, and cost-effective solutions to merge different optical modalities in one tool for sample analysis at the same point. This spatial synchronization of the analysis is critical for heterogeneous samples. Recent advances in optical fiber manufacturing significantly expand the wavelength range of the analysis from 0,3-2µm range with Silica fibers towards middle IR (with chalcogenide, AgCl:AgBr Polycrystalline PIR fibers, and Ag/AgI hollow glass waveguides covering together 1-20 µm range). We were able to fuse all 4 key spectroscopic methods (Fluorescence, NIR, MIR, and Raman) in compact fiber probes. In preliminary studies of tissue samples we showed that a combination of fluorescence with NIR or ATR-IR spectroscopy results in much better accuracy of the tumor margin detection than each of the individual methods separately. This synergy is explained by the capability of different light modalities to deliver complementary chemical information. We are using information from fluorescence background subtracted from Raman spectra to enhance the accuracy of the analysis. This concept, combined with advanced chemometrics data analysis, enables the development of customized spectral fiber sensors based only on several wavelengths or wavelength regions. Our recent experiments have shown the possibility of combining mid-IR ATR absorption and Raman spectroscopy in one compact fiber-optic probe. Thus it is possible to obtain an extended optical spectrum of molecular vibrations from the same point of a complex sample. These advances turn fiber-optic multispectral probes into the universal tool for applications that require in vivo analysis or real-time process monitoring.

Proceedings Article | 5 March 2021 Presentation

Flexible solutions in 0.3-16µm range for advanced laser, IR-imaging and multispectral applications

Viacheslav Artyushenko, Alexey Bocharnikov, Georg Kuka, Tatiana Sakharova, Iskander Usenov, Manfred Wittmann

Proceedings Volume 11635, 1163507 (2021) https://doi.org/10.1117/12.2578792

KEYWORDS: Laser applications, Optical fibers, Quantum cascade lasers, Mid-IR, Tissue optics, Thermography, Spectroscopy, Laser optics, Hollow waveguides, Fiber optics

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Proceedings Article | 1 April 2020 Presentation

Fiber photonics solutions for tissue analysis for fast biomedical diagnostics (Conference Presentation)

Olga Bibikova, Alena Sergeeva, Stanislav Perevoschikov, Raushania Gaynullina, Iskander Usenov, Valeria Belikova, Anastasya Melenteva, Alexey Bocharnikov, Tatiana Sakharova, Evgeny Shirshin, Alexander Tonevitsky, Viacheslav Artyushenko

Proceedings Volume 11359, 113590D (2020) https://doi.org/10.1117/12.2555420

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Proceedings Article | 9 March 2020 Presentation

Mid-infrared fiber spectroscopy for detection of cartilage degeneration in osteoarthritis (Conference Presentation)

Olga Bibikova, Valentin Mironovich, Iskander Usenov, Elena Feliksberger, Alexey Bocharnikov, Anastasia Surkova, Valeria Belikova, Ervin Nippolainen, Isaac Afara, Julian Haas, Vesa Virtanen, Lassi Rieppo, Harold Brommer, René van Weeren, Michael Pleyer, Johannes Koeth, Markus Nägele, Juha Töyräs, Boris Mizaikoff, Tatiana Sakharova, Viacheslav Artyushenko

Proceedings Volume 11233, 112330J (2020) https://doi.org/10.1117/12.2544893

KEYWORDS: Spectroscopy, Cartilage, Mid-IR, Quantum cascade lasers, FT-IR spectroscopy, Tissues, Molecules, Molecular spectroscopy, Fiber optics, Diagnostics

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Proceedings Article | 9 March 2020 Presentation

Intra-operative assessment of tumor resection margins by Raman spectroscopy to guide oral cancer surgery (Conference Presentation)

Gerwin Puppels, Elisa M. Barroso, Yassine Aaboubout, Maria Rosa Nunes Soares, Viacheslav Artyushenko, Alexey Bocharnikov, Iskander Usenov, Tom Bakker-Schut, Robert Baatenburg de Jong, Eppo Wolvius, Ivo ten Hove, Hetty Mast, Jose A. Hardillo, Aniel Sewnaik, Cees Meeuwis, Florence van Lanschot, Dominiek Monserez, Stijn Keereweer, Martin van der Wolf, Elena Sokolova, Senada Koljenovic

Proceedings Volume 11236, 1123607 (2020) https://doi.org/10.1117/12.2544394

KEYWORDS: Tumors, Raman spectroscopy, Cancer, Surgery, Tissues, Natural surfaces, Fiber optics, Spectroscopy, Tissue optics, Skin

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Proceedings Article | 24 May 2018 Presentation

Single- and multispectral fiber probes as a solution for guided diagnostics and therapy (Conference Presentation)

Olga Bibikova, Urszula Zabarylo, Valeria Belikova, Anastasija Melenteva, Iskander Usenov, Thaddäus Hocotz, Tatiana Sakharova, Alexey Bocharnikov, Georgy Danielyan, Olaf Minet, Hans Eichler, Viacheslav Artyushenko

Proceedings Volume 10685, 106851K (2018) https://doi.org/10.1117/12.2307424

KEYWORDS: Diagnostics, Fluorescence spectroscopy, Luminescence, Fiber optics, Raman spectroscopy, Tissue optics, Spectroscopy, Cancer, Biopsy, Tissues

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Medical fiber optics as a part of laboratory and clinical diagnostic tools, surgical instrumentation and endoscopy should satisfy modern biomedical requirements. The flexibility, small size, bio-compatibility and feasibility to use sterilisable or disposable parts allow to apply fiber optic probes in clinical environment both ex-vivo and in-vivo. To enable spectroscopic differentiation cancer and normal tissue, we developed and applied various single and combined fiber optic probes using key spectroscopy methods such as Raman scattering, Mid IR-absorption, Diffuse NIR-reflection, and fluorescence in order to compare them and select the best combination for malignant detection of tissue in clinical environment. All four spectroscopic methods have been tested on biopsies of health and malignant tissues (colon and kidney) and bioliquids (serum, plasma and urine) of patients before and after surgery. The tiny Raman probe with 1.5 mm diameter has been developed for experimental ex-vivo tests. Further multivariate data analysis of spectroscopic data, both individual techniques and their combinations has provided a reliable cancer recognition for colon and kidney biopsies. The best synergic gain was observed of combining Mid IR-absorption and fluorescence spectroscopy (98% Sensitivity vs 63% or 88% for fluorescence or Mid IR-absorption correspondingly). Based on obtained results, both techniques were implemented within the same fiber probe to provide a simultaneous measurement of exactly the same spot at the sample surface. An innovative combi Fluo-ATR probe was designed, fabricated and tested. Diffuse NIR-reflection and fluorescence spectroscopy as the fastest measurement techniques were used for investigation of surgically removed colorectal tissue samples in a few minutes after resection. Taking into account the necessity of rapid measurement process, we developed multispectral NIR-UV probe that enables efficient excitation and collection of NIR diffuse reflectance and fluorescence spectra of the same point. Needle probe design with diameter 0.7 mm allows to penetrate in some depth of tissue and obtain most reliable spectra avoiding artefacts related to surface drying. Multivariate data analysis proved the increased sensitivity of methods combination in one dataset (94% Sensitivity vs 85% or 85% for fluorescence or NIR reflection correspondingly).

Showing 5 of 8 publications

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