Alexey Popov graduated from Physics Department of M.V. Lomonosov Moscow State University (Russia) in 2003, received his PhD in 2006 from the same university and his D.Sc.(Tech.) degree from the University of Oulu (Finland) in 2008. He performed his postdoctoral research also in Oulu, with frequent visits abroad and formed an extensive collaboration network spreading from Australia to Russia and Europe. He is currently an assistant professor in the University of Oulu focusing on research and supervision of Master's and Doctoral students. His scientific interests are in the area of nanobiophotonics, nanoparticle-light-tissue-cell interaction, including biotissue-mimicking phantoms, deep-tissue imaging using up-conversion nanoparticles, enhancement of skin UV protection by sunscreens, cell optoporation by plasmonic nanostructures. He has published 70+ papers in peer-reviewed journals and SPIE proceedings and polished his leadership and communication skills when organizing three conferences in Finland: Advanced Laser Technologies (ALT) in 2007, Laser Applications in Life Sciences (LALS) in 2010 and Optics Days (2011). He is a member of International Program Committee of Saratov Fall Meeting and a member of advisory board of the LALS conference.
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There exist several potential optical measurement techniques to be utilised for the purpose. The most desired method would allow the detection of the drugs without using optical biomarkers as a contrast agent. In this case, for non-invasive sensing of the drug in the brain cortex, the drug should have a reasonably strong optical absorption band somewhere in the range between 600 nm and 1700 nm, and not directly coincident with the strong bands of haemoglobin or water. Alternatively, mid-infrared (MIR) range has the potential for invasive drug monitoring techniques.
In this paper, we report the optical properties of several chemotherapy drugs used in CNS lymphoma therapy, such as rituximabi, cyclophosphamide and etoposide. We measured their transmittance and reflectance spectra in near-infrared (NIR) range, particularly 900 nm − 2500 nm, to be considered when choosing the in vivo monitoring method to be developed. The absorption and scattering coefficients were retrieved from the measurements and applying Beer’s law. For the measurement of the sum of total transmission and reflection in NIR range we used integrating sphere with spektralo to enable calculation of the scattering coefficient.
Monitoring of temperature-mediated adipose tissue phase transitions by refractive-index measurements
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