This paper documents the results of the first in a series of experiments designed to evaluate the suitability of a novel, high resolution, color, digital, LCD panel for diagnostic quality, gray scale image display. The goal of this experiment was to measure the performance of this display especially with respect to luminance. A DICOM Part 14 calibration of the panel was done using both a pure gray look up table and a color look up table. The panel evaluated was the IBM T221 22.2" backlit AMLCD display with native resolution of 3840 × 2400 pixels. Taking advantage of the color capabilities of the workstation, we were able to create a 256 entry grayscale calibration look up table derived from a palette of 1786 nearly gray luminance values. We also constructed a 256 entry gray-scale calibration look up table derived from a palette of 256 true gray values for which the red, green, and blue values were equal. For the DICOM calibration derived from the 256 palette, 45 of the 256 shades of gray were redundant. For the DICOM calibration derived from a 1786 palette, all shades of gray were different and the luminance change between each gray level accurately agreed with the DICOM part 14 standard. These calibrations will now be used in our subsequent evaluation of human contrast - detail perception on this panel.