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Amit Saha

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Proceedings Article | 2 November 2016 Presentation

Achieving magneto-elasto-electroporation and cell transport using core-shell magnetoelectric nanoparticles (Conference Presentation)

Soutik Betal, Moumita Dutta, Binita Shrestha, Amit Saha, Liang Tang, Ananad Ramasubramanian, Amar Bhalla, Ruyan Guo

Proceedings Volume 9958, 99580A (2016) https://doi.org/10.1117/12.2238023

KEYWORDS: Nanoparticles, Magnetism, Ferroelectric materials, Coating, Confocal microscopy, Absorption, In vitro testing, Transmission electron microscopy, Atomic force microscopy, Acoustics

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Magneto-Elasto-Electroporation (MEEP) is a magnetically controlled acoustic-electroporation observed while core-shell Magneto-electric nanoparticles interact with Biological Cells. The surface polarity change of the piezoelectric coating (BaTiO3) due to absorption of pressure created due magneto-striction of core (CoFe2O4) in AC magnetic field results in electric field (Uext) change at the external vicinity of the cell membrane when nanoparticles are nearby. This results in transmembrane Voltage (Um) change which is basically the difference in Cell’s internal potential (Uint) and external potential. The nonlinear permeability change of cell membrane due to change in Um opens the nano-pores on the membrane. The magnetic moment of the nanoparticles further helps in penetration of the Magneto-electric nanoparticles inside the cell through these magneto-electrically controlled newly opened nano-pores on cell’s membrane. MEEP is analyzed through in-vitro analysis and Mathematical equations are formulated for numerically expressing its fundamental effect. TEM imaging, XRD analysis, Zeta-potentiometer measurement and AFM imaging are confirming the coating of the piezoelectric layer on Magneto-stricitve nanoparticles, Acoustic measurements confirms the photo-acoustic and magneto-acoustic property of CoFe2O4 nanoparticles and Fluorescence microscopy as well as Confocal microscopy are confirming the penetration of particle inside the Human Epithelial cells (HEP2). Further on application of repulsive magnetic field, nanoparticles are observed to transport a group of cells in controlled boundary conditions in microfluidic chamber. Hence these nanoparticles can be used for accurate and efficient drug delivery as well as cell transport applications

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