Dr. Anastasia V. Ryabova Profile

Dr. Anastasia V. Ryabova

at GPI RAS

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Author

Publications (14)

Proceedings Article | 29 April 2022 Paper

Study of energy transfer processes between the rare earth ions in tri-doped upconversion nanoparticles NaGdF4:Yb-Er-Tm and NaGdF4:Yb-Er-Ho

Daria Pominova, Vera Yu. Proydakova, Igor Romanishkin, Pavel Grachev, Sergei Kuznetsov, Anastasia Ryabova

Proceedings Volume 12194, 1219411 (2022) https://doi.org/10.1117/12.2626223

KEYWORDS: Luminescence, Thulium, Nanoparticles, Short wave infrared radiation, Erbium, Energy transfer, Ions, Holmium, Ytterbium, Visible radiation

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Proceedings Article | 7 August 2019 Paper

Possible approaches to fluorescence diagnosis and photodynamic therapy for deep-seated tumors

Victor Loschenov, Tatiana Savelieva, Pavel Grachev, Kirill Linkov, Yuliya Maklygina, Igor Romanishkin, Anastasia Ryabova, Daniil Kustov, Sergey Goryajnov, Alexander Potapov

Proceedings Volume 11070, 110706B (2019) https://doi.org/10.1117/12.2526013

KEYWORDS: Tumors, Luminescence, Tissues, Picosecond phenomena, Brain, Video, Biopsy, Photodynamic therapy, Spectroscopy, Cerenkov radiation imaging

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The limited penetration of laser radiation into biological tissue prevents the widespread distribution of photodiagnostics (PD) and photodynamic therapy (PDT) methods to clinical practice. We have investigated several approaches for PD and PDT of deep-seated tumors: 1. Stereotactic biopsy cannula with a laser spectroscopic control. Special fiber ports for long-term installation in the tumor removal area were developed in order to cause tumor cells to migrate not into the depth of brain but along the fibers with occasional laser irradiation for PD and PDT. The fibers are coated with a special compound containing photosensitizer (PS) and nutrients for cancer cells. 2. Neurosurgical aspirator with the function of video-fluorescence and spectroscopic analysis system. More than 500 patients with various types of brain tumors were operated on using fluorescent navigation based on 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (Pp IX) fluorescence under laser excitation in red spectral range. 3. Diagnostics and navigation of tumors when fluorescence is excited in the red and near infrared ranges. We used indocyanine green (ICG) as near infrared dye to observe blood and lymph vasculature of laboratory animals. This method could be useful while examining tumor bed and adjacent area. 4. Joint action of radiopharmaceuticals and PS based on Cherenkov radiation. Cell death by PDT mechanism via Pp IX excitation by Cherenkov radiation in mitochondria during 18F-fludeoxyglucose decay. This idea achieved good results on rats with C6 glioma. The results of using this approach with chlorin e6 PS in comparable doses are negative. 5. Action through photodynamic inactivation of tumor-associated macrophages and microglia. Idea of minimally invasive method for determining macrophage (microglia) phenotype and their polarization in tumors and their immediate vicinity in situ. This would allow evaluating the effectiveness of the treatment, including PDT. The most promising results were obtained with Pp IX and aluminum phthalocyanine nanoparticles. Studies have been conducted on experimental animals with grafted tumors and, in part, on cancer patients in the clinic.

Proceedings Article | 3 June 2019 Paper

Investigation of Ce6 accumulation and distribution in cell cultures of head and neck cancers

Dina Farrakhova, Yulia Maklygina, Igor Romanishkin, Anastasia Ryabova, Ilya Yakavets, Marie Millard, Lina Bolotine, Anna Plyutinskaya, Tatyana Karmakova, Andrey Pankratov, Victor Loschenov

Proceedings Volume 11065, 110651V (2019) https://doi.org/10.1117/12.2523465

KEYWORDS: Luminescence, 3D modeling, Photodynamic therapy, Cancer, Microscopy, Tumor growth modeling, Fluorescence lifetime imaging, Tumors, Head, Neck

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Proceedings Article | 3 June 2019 Paper

Strategies to enhance the sensitivity of NaGdF4:Yb-Tm based nanothermometers

Daria Pominova, Vera Yu. Proydakova, Igor Romanishkin, Anastasiya Ryabova, Pavel Grachev, Sergey Kuznetsov, Valerii Voronov, Pavel Fedorov

Proceedings Volume 11067, 110671B (2019) https://doi.org/10.1117/12.2523177

KEYWORDS: Luminescence, Ytterbium, Upconversion, Nanoparticles, Thulium, Temperature metrology, Fluorine, Calibration, Ions, Thermometry

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Proceedings Article | 28 May 2018 Paper

Optical fiber neurosystem for deep-lying brain tumors phototheranostics

Alina Sharova, Yuliya Maklygina , Igor Romanishkin , Gaukhar Yusubalieva, Anastasia Ryabova, Vladimir Сhekhonin, Victor Loschenov

Proceedings Volume 10695, 106950O (2018) https://doi.org/10.1117/12.2312027

KEYWORDS: Brain, Tumors, Optical fibers, Fiber optics, Tissues, Diagnostics, Photodynamic therapy, Luminescence, Tissue optics

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Proceedings Article | 24 May 2018 Presentation + Paper

Bioimaging with controlled depth using upconversion nanoparticles

D. Pominova, A. Ryabova, I. Romanishkin, V. Makarov, P. Grachev

Proceedings Volume 10677, 106770O (2018) https://doi.org/10.1117/12.2309780

KEYWORDS: Luminescence, Upconversion, Monte Carlo methods, Photons, Tissues, Nanoparticles, Scattering, Biological research, Light scattering

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Proceedings Article | 24 May 2018 Paper

Multispectral imaging technique for skin grafts’ functional state assessment

V. Makarov, D. Pominova, A. Ryabova, T. Saveleva, I. Ignateva, I. Reshetov, V. Loschenov

Proceedings Volume 10677, 1067734 (2018) https://doi.org/10.1117/12.2309783

KEYWORDS: Skin, Luminescence, Tissues, Tissue optics, Nanoparticles, Blood, Transplantation, Spectroscopy, Blood circulation, Optical fibers

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Proceedings Article | 26 April 2018 Paper

Experimental modeling of local laser hyperthermia using thermosensitive nanoparticles absorbing in NIR

Igor Romanishkin, Pavel Grachev, Daria Pominova, Ivan Burmistrov, Ilmo Sildos, Alexander Vanetsev, Elena Orlovskaya, Yuri Orlovskii, Victor Loschenov, Anastasia Ryabova

Proceedings Volume 10716, 107161C (2018) https://doi.org/10.1117/12.2309459

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Proceedings Article | 26 April 2018 Paper

Multifunctional upconversion nanoparticles based on NaYGdF4 for laser induced heating, non-contact temperature sensing and controlled hyperthermia with use of pulsed periodic laser excitation

Daria Pominova, Anastasia Ryabova, Igor Romanishkin, Pavel Grachev, Ivan Burmistrov, Sergei Kuznetsov

Proceedings Volume 10716, 107161B (2018) https://doi.org/10.1117/12.2312484

KEYWORDS: Luminescence, Upconversion, Nanoparticles, Quantum efficiency, Temperature metrology, Ytterbium, Pulsed laser operation, Erbium, Gadolinium, Continuous wave operation

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SPIE Journal Paper | 20 December 2017 Open Access

Femtosecond laser surgery of two-cell mouse embryos: effect on viability, development, and tetraploidization

Alina Osychenko, Alexandr D. Zalessky, Andrey Kostrov, Anastasia Ryabova, Alexander Krivokharchenko, Victor Nadtochenko

JBO, Vol. 22, Issue 12, 125006, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.125006

KEYWORDS: Femtosecond phenomena, Laser therapeutics, Fusion energy, Surgery, Pulsed laser operation, Luminescence, Absorption, Laser energy, Clocks, Laser welding

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SPIE Journal Paper | 8 September 2016 Open Access

Upconversion microparticles as time-resolved luminescent probes for multiphoton microscopy: desired signal extraction from the streaking effect

Daria Pominova, Anastasia Ryabova, Pavel Grachev, Igor Romanishkin, Sergey Kuznetsov, JUlia Rozhnova, Daria Yasyrkina, Pavel Fedorov, Victor Loschenov

JBO, Vol. 21, Issue 09, 096002, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.096002

KEYWORDS: Upconversion, Luminescence, Ytterbium, Nanoparticles, Particles, Ions, Erbium, Deconvolution, Microscopy, Point spread functions

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Proceedings Article | 15 July 2015 Paper

Raman and fluorescence microscopy to study the internalization and dissolution of photosensitizer nanoparticles into living cells

Claudia Scalfi-Happ, Rudolf Steiner, Rainer Wittig, Susanna Graefe, Anastasia Ryabova, Victor Loschenov

Proceedings Volume 9537, 953705 (2015) https://doi.org/10.1117/12.2183726

KEYWORDS: Luminescence, Raman spectroscopy, Nanoparticles, Microscopy, Confocal microscopy, Photodynamic therapy, Imaging spectroscopy, Signal detection, Laser scanners, Crystals

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Proceedings Article | 2 March 2015 Paper

Crystalline organic nanoparticles for diagnosis and PDT

R. Steiner, J. Breymayer, Angelika Rueck, V. Loschenov, A. Ryabova

Proceedings Volume 9308, 93080R (2015) https://doi.org/10.1117/12.2080773

KEYWORDS: Luminescence, Nanoparticles, Photodynamic therapy, Skin, Aluminum, Tissues, Crystals, Molecules, Tumors, Tissue optics

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Proceedings Article | 7 December 2006 Paper

In vivo evaluation of accumulation of sensitizers for oncological diagnostics and therapy using the method of diffuse reflectance spectroscopy

I. Meerovich, A. Stratonnikov, A. Ryabova, G. Meerovich, N. Oborotova, A. Brandis, E. Lukyanets, O. Kaliya, P. Bendel, V. Loschenov, A. Scherz, A. Baryshnikov

Proceedings Volume 5973, 59730H (2006) https://doi.org/10.1117/12.640052

KEYWORDS: Absorption, Tumors, Tissues, In vivo imaging, Tissue optics, Diagnostics, Diffuse reflectance spectroscopy, Biological research, Photodynamic therapy, Manganese

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