Prof. Andrew M. Rollins Profile

Prof. Andrew M. Rollins

Professor at Case Western Reserve Univ

SPIE Involvement:

Conference Program Committee | Author | Editor

Publications (105)

Proceedings Article | 13 March 2024 Poster

Clinical study of normal, keratoconus, and post-surgical corneas with phase decorrelation OCT

Brecken Blackburn, Lara Asroui, Imane Tarib, Dushani Dunukara, Matthew McPheeters, Michael Jenkins, J. Bradley Randleman, William Dupps, Andrew Rollins

Proceedings Volume PC12824, PC128241R (2024) https://doi.org/10.1117/12.3005510

KEYWORDS: Cornea, Optical coherence tomography, Tissues, Surgery, Head, Windows, Specular reflections, Scanners, Reflection, Phase shifts

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Proceedings Article | 13 March 2024 Presentation

High density optical substrate mapping of the left atrium with near infrared spectroscopy

Haiqiu Yang, Jonah Majumder, Ziyi Huang, Kenneth Laurita, Andrew Rollins, Christine Hendon

Proceedings Volume 12819, 128190S (2024) https://doi.org/10.1117/12.3002814

KEYWORDS: Near infrared spectroscopy, Tissue optics, Spectral density, Blood, Absorbance, Radio optics, Atrial fibrillation, Visualization, Tissues, Radiofrequency ablation

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Proceedings Article | 13 March 2024 Presentation

Catheter-based diffuse reflectance spectroscopy for cardiac substrate mapping

Jonah Majumder, Haiqiu Yang, Ziyi Huang, Aidan Therien, Kenneth Laurita, Andrew Rollins, Deepak Saluja, Christine Hendon

Proceedings Volume PC12836, PC128360B (2024) https://doi.org/10.1117/12.3001935

KEYWORDS: Diffuse reflectance spectroscopy, Tissues, Radiofrequency ablation, Atrial fibrillation, Ablation, Tissue optics, Reflectivity, Photons, Biological samples, Spectroscopy

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Proceedings Article | 13 March 2024 Presentation + Paper

PSOCT, NIRS, and optical mapping of low voltage zones in atrial fibrillation

Michael Douglass, Lydia Akino, Juan Perez, Haiqiu Yang, Jonah Majumder, Walter Hoyt, Ohad Ziv, Kenneth Laurita, Christine Hendon, Andrew Rollins

Proceedings Volume 12819, 128190R (2024) https://doi.org/10.1117/12.3001724

KEYWORDS: Atrial fibrillation, Near infrared spectroscopy, Tissues, Ablation, In vivo imaging, Tissue optics, Heart, Birefringence, Veins, Pathology

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Atrial fibrillation (AF) is the most common arrhythmia worldwide. An increasingly common treatment option is catheter ablation. During this procedure, the clinician steers a catheter into the left atrium and ablates a lesion fence around the pulmonary veins, a common source of ectopic signals. This lesion fence blocks arrhythmogenic tissue from initiating an erroneous heartbeat. However, if the disease has progressed from paroxysmal to persistent, pathogenic tissue exists throughout the atrium, and common ablation schemes are not as effective. In this case, technologies exist to electroanatomically map the atrium and guide clinicians in targeting adjunctive AF ablation targets. Low voltages mapped in vivo are a well-documented way of identifying atrial fibrosis, an important substrate for AF. Ablating low voltage zones in patients with a more developed disease can help terminate AF and improve long-term outcomes, but low voltage measurements are not specific to fibrosis. Treatment results vary because the targeting that electroanatomical mapping provides is incomplete. Our group has shown that polarization-sensitive optical coherence tomography (PSOCT) and near infrared spectroscopy (NIRS) can monitor lesion formation in vivo and differentiate tissue types in the atrium. Now, we are investigating the technology’s utility in identifying AF targets prior to ablation. We have collaborated in developing a swine model of AF that shows the atria remodels during the diseased state. Because of this, we can electroanatomically map these diseased hearts in vivo to measure low voltage zones. Subsequently, we examine the left atrium ex vivo using benchtop PSOCT, NIRS, and optical mapping (OM) and register these optical measurements to the in vivo low voltage zones. We show that OM confirms abnormal conduction, while PSOCT- and NIRS-derived metrics have promise for identifying low voltage zones. We confirm these measures with histological identification of fibrosis. This suggests the feasibility of using PSOCT-NIRS at the catheter tip to detect AF ablation targets.

Proceedings Article | 13 March 2024 Paper

A multimodal PSOCT-NIRS catheter for ablation of atrial fibrillation

Michael Douglass, Reza Mohammadpour, Gauri Srikumar, Alice Qian, Juan Perez, Jonah Majumder, Christine Hendon, Kenneth Laurita, Walter Hoyt, Ohad Ziv, Andrew Rollins

Proceedings Volume 12834, 1283407 (2024) https://doi.org/10.1117/12.3006074

KEYWORDS: Ablation, Near infrared spectroscopy, Atrial fibrillation, Tissues, Optical coherence tomography, Heart, Radiofrequency ablation, Polarization, In vivo imaging, Birefringence

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SPIE Journal Paper | 28 February 2024 Open Access

Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy

Haiqiu Yang, Jonah Majumder, Ziyi Huang, Deepak Saluja, Kenneth Laurita, Andrew Rollins, Christine Hendon

JBO, Vol. 29, Issue 02, 028001, (February 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.2.028001

KEYWORDS: Tissues, Blood, Near infrared spectroscopy, Tissue optics, Radiofrequency ablation, Heart, Ablation, Data modeling, Education and training, Reflectivity

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SPIE Journal Paper | 3 October 2023 Open Access

Image harmonization and deep learning automated classification of plus disease in retinopathy of prematurity

Ananya Subramaniam, Faruk Orge, Michael Douglass, Basak Can, Guillermo Monteoliva, Evelin Fried, Vanina Schbib, Gabriela Saidman, Brenda Peña, Soledad Ulacia, Pedro Acevedo, Andrew M. Rollins, David L. Wilson

JMI, Vol. 10, Issue 06, 061107, (October 2023) https://doi.org/10.1117/12.10.1117/1.JMI.10.6.061107

KEYWORDS: Deep learning, Image classification, Diseases and disorders, Image enhancement, Education and training, Image quality, Vascular diseases, Image processing, Retinal diseases, Diagnostics

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Proceedings Article | 17 March 2023 Presentation

Multi-modal imaging system with optically integrated probe for left atrial anatomical mapping

Haiqiu Yang, Michael Douglass, Deepak Saluja, Kenneth Laurita, Andrew Rollins, Christine Hendon

Proceedings Volume PC12355, PC1235507 (2023) https://doi.org/10.1117/12.2650336

KEYWORDS: System integration, Radiofrequency ablation, Multimodal imaging, Integrated optics, Imaging systems, Tissues, Radio optics, Optical coherence tomography, Near infrared spectroscopy, Blood

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Proceedings Article | 17 March 2023 Presentation

Highly multiplexed 3D FISH imaging in the embryonic quail heart

Junwoo Suh, Yehe Liu, Andrew Rollins, Michiko Watanabe, Michael Jenkins

Proceedings Volume PC12355, PC123550D (2023) https://doi.org/10.1117/12.2650229

KEYWORDS: Heart, Stereoscopy, Multiplexing, 3D image processing, Visualization, Tissue clearing, Luminescence, Hemodynamics, Blood circulation, 3D modeling

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Proceedings Article | 16 March 2023 Presentation

Investigating corneal properties through temporal decorrelation in OCT images (Conference Presentation)

Brecken Blackburn, Matthew McPheeters, Michael Jenkins, William Dupps, Andrew Rollins

Proceedings Volume PC12393, PC1239301 (2023) https://doi.org/10.1117/12.2650813

KEYWORDS: Optical coherence tomography, Cornea, In vivo imaging, Tissues, Spatial resolution, Scattering, Optical resolution, Optical coherence microscopy, Dynamic light scattering, Anisotropy

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Proceedings Article | 14 March 2023 Presentation + Paper

Polarization-Sensitive Optical Coherence Tomography (PSOCT) for identifying and analyzing gaps in lesion lines during ex vivo simulated radiofrequency ablation procedure

Michael Douglass, Juan Perez, Lydia Akino, Haiqiu Yang, Walter Hoyt, Ohad Ziv, Kenneth Laurita, Christine Hendon, Andrew Rollins

Proceedings Volume 12355, 1235503 (2023) https://doi.org/10.1117/12.2650838

KEYWORDS: Ablation, Tissues, Atrial fibrillation, Radiofrequency ablation, Polarization, Birefringence, Optical coherence tomography

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Proceedings Article | 7 March 2022 Presentation

Cardiac tissue substrate mapping with polarization-sensitive optical coherence tomography

Xiaowei Zhao, Ohad Ziv, Michael Douglass, Walter Hoyt, Michael Jenkins, Christopher Snyder, Christine Hendon, Kenneth Laurita, Andrew Rollins

Proceedings Volume PC11936, PC1193606 (2022) https://doi.org/10.1117/12.2607820

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Proceedings Article | 7 March 2022 Presentation

Functional neuroimaging of the corneal nerves longitudinally and in vivo

Matthew McPheeters, Brecken Blackburn, William Dupps, Andrew Rollins, Michael Jenkins

Proceedings Volume PC11941, PC119410E (2022) https://doi.org/10.1117/12.2609039

KEYWORDS: In vivo imaging, Neuroimaging, Nerve, Nervous system, Functional imaging, Cornea, Therapeutics, Eye

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Proceedings Article | 7 March 2022 Presentation

Phase decorrelation-OCT for monitoring the depth-dependent effect of accelerated corneal crosslinking

Brecken Blackburn, Matthew McPheeters, Michael Jenkins, William Dupps, Andrew Rollins

Proceedings Volume 11941, 1194108 (2022) https://doi.org/10.1117/12.2609215

KEYWORDS: Oxygen, Cornea, Optical coherence tomography, Ultraviolet radiation, Tissues

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Proceedings Article | 7 March 2022 Presentation

Cardiac endocardial left atrial substrate mapping and lesion depth assessment using near-infrared spectroscopy

Soo Young Park, Haiqiu Yang, Charles Marboe, Ohad Ziv, Kenneth Laurita, Andrew Rollins, Deepak Saluja, Christine Hendon

Proceedings Volume PC11936, PC1193609 (2022) https://doi.org/10.1117/12.2610367

KEYWORDS: Near infrared spectroscopy, Veins, Associative arrays, Tissue optics, Tissues, Systems modeling, Spectroscopy, Natural surfaces, Heart, Diffuse reflectance spectroscopy

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Proceedings Article | 2 March 2022 Presentation

Deep learning tissue segmentation of beating embryonic hearts from 4-D OCT images

Shan Ling, Jiawei Chen, Brecken Blackburn, Maryse Lapierre-Landry, Stephanie Ford, Michael Jenkins, Michiko Watanabe, Andrew Rollins

Proceedings Volume PC11959, PC1195901 (2022) https://doi.org/10.1117/12.2615082

KEYWORDS: Image segmentation, Heart, Optical coherence tomography, Tissues, Imaging systems, Motion analysis, Doppler tomography, Blood circulation, Bioalcohols

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Proceedings Article | 5 March 2021 Poster + Paper

Assessing cataract formation ex vivo with phase decorrelation OCT

Brecken Blackburn, Matthew McPheeters, Michael Jenkins, William Dupps, Andrew Rollins

Proceedings Volume 11623, 116231S (2021) https://doi.org/10.1117/12.2578479

KEYWORDS: Optical coherence tomography, Animal model studies, Proteins, Systems modeling, Ophthalmology, Opacity, Light scattering, In vivo imaging, Dynamic light scattering, Diagnostics

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Proceedings Article | 5 March 2021 Presentation

Optical coherence tomography for transseptal puncture procedure guidance

Xiaowei Zhao, Orhan Kilinc, Michael Douglass, Walter Hoyt, Kaushal Dosani, Michael Jenkins, Ohad Ziv, Kenneth Laurita, Christopher Snyder, Andrew Rollins

Proceedings Volume 11621, 1162105 (2021) https://doi.org/10.1117/12.2583457

KEYWORDS: Optical coherence tomography, Tissue optics, In vivo imaging, Heart, Fluoroscopy, Visualization, Tissues, Safety, Real time imaging, Ionizing radiation

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Proceedings Article | 5 March 2021 Presentation

Imaging of the corneal nerves ex vivo and in vivo using genetically-encoded calcium indicators

Matthew McPheeters, Brecken Blackburn, William Dupps, Andrew Rollins, Michael Jenkins

Proceedings Volume 11623, 116230T (2021) https://doi.org/10.1117/12.2578018

KEYWORDS: Calcium, In vivo imaging, Nervous system, Cornea, Therapeutics, Nerve, Functional imaging, Eye, Electrophysiology, Alzheimer's disease

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Proceedings Article | 5 March 2021 Presentation

Automatic Endocardial Cushion Segmentation and EMT Cell Density Characterization Using Optical Coherence Tomography

Shan Ling, Maryse Lapierre-Landry, Stephanie Ford, Michael Jenkins, Michiko Watanabe, Andrew Rollins

Proceedings Volume 11621, 1162106 (2021) https://doi.org/10.1117/12.2583285

KEYWORDS: Image segmentation, Optical coherence tomography, Heart, Image processing, Data modeling, Bioalcohols, 3D modeling

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Proceedings Article | 5 March 2021 Poster + Presentation

Quantitative assessment of transmurality of in vivo left atrium radiofrequency ablation lesions by polarization-sensitive optical coherence tomography

Xiaowei Zhao, Ohad Ziv, Walter Hoyt, Michael Jenkins, Christopher Snyder, Kenneth Laurita, Andrew Rollins

Proceedings Volume 11630, 116301Y (2021) https://doi.org/10.1117/12.2583918

KEYWORDS: Radiofrequency ablation, Optical coherence tomography, In vivo imaging, Atrial fibrillation, Image quality, Tissues, Veins, Real time imaging, Photovoltaics, Image resolution

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SPIE Journal Paper | 8 May 2020 Open Access

Intracardiac radiofrequency ablation in living swine guided by polarization-sensitive optical coherence tomography

Xiaowei Zhao, Orhan Kilinc, Colin Blumenthal, Deniz Dosluoglu, Michael Jenkins, Christopher Snyder, Mauricio Arruda, Andrew Rollins

JBO, Vol. 25, Issue 05, 056001, (May 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.5.056001

KEYWORDS: Radiofrequency ablation, Tissues, Optical coherence tomography, Birefringence, Electrodes, Heart, Tissue optics, Polarization, Atrial fibrillation, Video

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Proceedings Article | 9 March 2020 Presentation

Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)

Brecken Blackburn, John Murray, Matthew Ford, Michael Jenkins, William Dupps, Andrew Rollins

Proceedings Volume 11218, 112180W (2020) https://doi.org/10.1117/12.2546557

KEYWORDS: Optical coherence tomography, Cornea, Elastography, Diagnostics, Analytical research, Biological research, Dynamic light scattering, Statistical analysis, Detection theory

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Proceedings Article | 9 March 2020 Presentation

Polarization sensitive optical coherence tomography-guided percutaneous radiofrequency ablation in left atrium of living swine (Conference Presentation)

Xiaowei Zhao, Ohad Ziv, Reza Mohammadpour, Benjamin Crosby, Walter Hoyt, Kaushal Dosani, Michael Jenkins, Christopher Snyder, Kenneth Laurita, Andrew Rollins

Proceedings Volume 11215, 1121509 (2020) https://doi.org/10.1117/12.2551530

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Proceedings Article | 4 March 2019 Presentation

Ex vivo measurement of biaxial strain distribution in articular cartilage with optical coherence tomography (Conference Presentation)

Brecken Blackburn, Mostafa Motavalli, Matthew Ford, Jean Welter, Joseph Mansour, Andrew Rollins

Proceedings Volume 10880, 1088006 (2019) https://doi.org/10.1117/12.2509681

KEYWORDS: Optical coherence tomography, Cartilage, Collagen, Tissues, Tissue optics, Connective tissue, Natural surfaces, 3D image processing

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SPIE Journal Paper | 27 April 2018 Open Access

Complex regression Doppler optical coherence tomography

Sahar Elahi, Shi Gu, Lars Thrane, Andrew Rollins, Michael Jenkins

JBO, Vol. 23, Issue 04, 046009, (April 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.4.046009

KEYWORDS: Doppler tomography, Optical coherence tomography, Signal to noise ratio, Phase measurement, Heart, Phase shifts, Blood circulation, Velocity measurements, Doppler effect, Video

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Proceedings Article | 14 March 2018 Presentation

Monitoring corneal crosslinking with phase-decorrelation OCT (Conference Presentation)

Brecken Blackburn, Shi Gu, Matthew Ford, Michael Jenkins, William Dupps, Andrew Rollins

Proceedings Volume 10474, 104740O (2018) https://doi.org/10.1117/12.2290628

KEYWORDS: Optical coherence tomography, Cornea, Motion measurement, Elastography, Collagen, Transplantation, Spatial resolution, Motion detection

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Proceedings Article | 14 March 2018 Presentation

Compression optical coherence elastography for micro-scale embryonic tissues (Conference Presentation)

Brecken Blackburn, Shi Gu, Michael Jenkins, Andrew Rollins

Proceedings Volume 10472, 104720M (2018) https://doi.org/10.1117/12.2290653

KEYWORDS: Elastography, Tissues, Tissue optics, Coherence (optics), Optical coherence tomography, Heart, Biomedical optics, Sensors, Calibration, 3D modeling

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Proceedings Article | 14 March 2018 Presentation

Using optical coherence tomography to detect disturbances in coronary microvascular in a model of fetal alcohol syndrome (Conference Presentation)

Meredith C. Broberg, Yehe Liu, Andrew Rollins, Michiko Watanabe, Michael Jenkins

Proceedings Volume 10472, 104720N (2018) https://doi.org/10.1117/12.2290815

KEYWORDS: Optical coherence tomography, Fetus, Tissue optics, Heart, Optical imaging, 3D image processing, 3D modeling, Bioalcohols, Scattering, Physiology

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Proceedings Article | 14 March 2018 Presentation

Semi-automated measurement of absolute blood velocity and shear stress in developing embryonic hearts using a MHz FDML swept laser source (Conference Presentation)

Sahar Elahi, Shi Gu, Andrew Rollins, Michael Jenkins

Proceedings Volume 10472, 104720R (2018) https://doi.org/10.1117/12.2291058

KEYWORDS: Heart, Optical coherence tomography, Doppler tomography, Blood, Blood circulation, Hemodynamics, Laser development, Laser sources, Laser stabilization, Ultrafast phenomena

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Proceedings Article | 14 March 2018 Presentation

Simple lipid-preserving optical clearing for fluorescent imaging (Conference Presentation)

Yehe Liu, Michiko Watanabe, Andrew Rollins, Michael Jenkins

Proceedings Volume 10499, 104991J (2018) https://doi.org/10.1117/12.2291174

KEYWORDS: Optical clearing, Tissues, Microscopy, Animal model studies, Tissue clearing, Confocal microscopy, Medical research, Tissue optics, Refractive index, Luminescence

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Proceedings Article | 14 March 2018 Presentation

Three-dimensional mapping of conduction velocity in early embryonic hearts (Conference Presentation)

Shan Ling, Matthew McPheeters, Shi Gu, Michiko Watanabe, Michael Jenkins, Andrew Rollins

Proceedings Volume 10472, 104720Q (2018) https://doi.org/10.1117/12.2290028

KEYWORDS: Heart, Tissue optics, Electrophysiology, Tissues, Associative arrays, Microscopy, Action potentials, Optical imaging, Physiology, Image analysis

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Proceedings Article | 14 March 2018 Presentation

integrated intra-cardiac catheter for polarization sensitive optical coherence tomography-guided radiofrequency ablation (Conference Presentation)

Xiaowei Zhao, Colin Blumenthal, Kilinc Orhan, Deniz Dosluoglu, Michael Jenkins, Christopher Snyder, Mauricio Arruda, Andrew Rollins

Proceedings Volume 10471, 104710P (2018) https://doi.org/10.1117/12.2290560

KEYWORDS: Radiofrequency ablation, Polarization, Optical coherence tomography, Tissues, Integrated optics, Radio optics, Coherence (optics), Image quality standards, Temperature metrology, Atrial fibrillation

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Proceedings Article | 14 March 2018 Presentation

A simple optical clearing method for investigating molecular distribution in intact embryonic tissues (Conference Presentation)

Yehe Liu, Michael Jenkins, Michiko Watanabe, Andrew Rollins

Proceedings Volume 10472, 104720P (2018) https://doi.org/10.1117/12.2291193

KEYWORDS: Tissues, Optical clearing, Confocal microscopy, Microscopy, Molecules, Biology, Refractive index, Diffusion, Heart, Brain

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Proceedings Article | 24 April 2017 Presentation

Decorrelation-based viscosity measurement using phase-sensitive optical coherence tomography (Conference Presentation)

Brecken Blackburn, Shi Gu, Michael Jenkins, Andrew Rollins

Proceedings Volume 10067, 1006711 (2017) https://doi.org/10.1117/12.2252462

KEYWORDS: Microfluidics, Speckle, Optical coherence tomography, Motion measurement, Particles, Diffusion, Tissues, Optical testing, Phase measurement, Blood

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