A major monitoring area, a part of the middle reaches of Heihe basin, was selected. The Landsat TM data in summer of 1990 and 2000 were used with interpretation on the computer screen, classification and setting up environmental investigation database (1:100000) combined with DEM, land cover/land use, land type data and etc., according to the environmental classification system. Then towards to the main problems of environment, the spatial statistical analysis and dynamic comparisons were carried out using the database. The dynamic monitoring results of 1999 and 2000 show that the changing percentage with the area of 6 ground objects are as follows: land use and agriculture land use increased by 34.17% and 19.47% respectively, wet land and water-body also increased by 6.29% and 8.03% respectively; unused land increased by 1.73% and the biggest change is natural/semi-natural vegetation area, decreased by 42.78%, the main results above meat with the requirements of precise and practical conditions by the precise exam and spot check. With the combinations of using TM remote sensing data and rich un-remote sensing data, the investigations of ecology and environment and the dynamic monitoring would be carried out efficiently in the arid area. It is a dangerous signal of large area desertification if the area of natural/semi-natural vegetation is reduced continuously and obviously.