We report a deep-learning based compact spectrometer. Using a spectral encoder chip composed of unique plasmonic tiles (containing periodic nanohole-arrays), diffraction patterns created by the transmitted light through these tiles are captured by a CMOS sensor-array, without the use of any lenses or other components between the plasmonic encoder and the CMOS-chip. A neural network rapidly reconstructs the input light spectrum from the recorded lensless image data, which was blindly tested on randomly-generated new spectra to demonstrate the success of this computational on-chip spectrometer, which will find applications in various fields that demand low-cost and compact spectrum analyzers.
We demonstrate a contact-lens (CL) based mobile sensing system which can be used to measure protein levels in human tear. By using a cost-effective mobile-phone-based well-plate reader and a fluorescent assay, we quantify lysozyme nonspecifically bound to CLs. We monitored the lysozyme levels of 9 healthy volunteers to establish individual baselines, and then compared these measurements to participants who had been diagnosed with Dry Eye Disease (N=6), observing a statistically significant difference in their means. Due to its non-invasive and simple operation, this method could be used for tear-based sensing and health monitoring applications in point-of-care settings and at home.