Wearable health monitoring systems have recently attracted widespread interest for their application in long term patient
monitoring. Wireless wearable technology enables continuous observation of patients while they perform their normal
everyday activities. This involves the development of flexible and conformable sensors that could be easily integrated to
the smart fabrics. Carbon nanotubes are found to be one of the ideal candidate materials for the design of
multifunctional e-textiles because of their capability to change conductance based on any mechanical deformation as
well as surface functionalization. This paper presents the development and characterization of a carbon nanotube (CNT)-polymer nanocomposite flexible strain sensor for wearable health monitoring applications. These strain sensors can be
used to measure the respiration rhythm which is a vital signal required in health monitoring. A number of strain sensor
prototypes with different CNT compositions have been fabricated and their characteristics for both static as well as
dynamic strain have been measured.
The bioelectrical potentials generated within the human body are the result of electrochemical activity in the excitable
cells of the nervous, muscular or glandular tissues. The ionic potentials are measured using biopotential electrodes which
convert ionic potentials to electronic potentials. The commonly monitored biopotential signals are Electrocardiogram
(ECG), Electroencephalogram (EEG) and Electromyogram (EMG). The electrodes used to monitor biopotential signals
are Ag-AgCl and gold, which require skin preparation by means of scrubbing to remove the dead cells and application of
electrolytic gel to reduce the skin contact resistance. The gels used in biopotential recordings dry out when used for
longer durations and add noise to the signals and also prolonged use of gels cause irritations and rashes to skin. Also
noises such as motion artifact and baseline wander are added to the biopotential signals as the electrode floats over the
electrolytic gel during monitoring. To overcome these drawbacks, dry electrodes are used, where the electrodes are held
against the skin surface to establish contact with the skin without the need for electrolytic fluids or gels. The major
drawback associated with the dry electrodes is the high skin-electrode impedance in the low frequency range between
0.1-120 Hz, which makes it difficult to acquire clean and noise free biopotential signals. The paper presents the design
and development of biopotential data acquisition and processing system to acquire biopotential signals from dry
electrodes. The electrode-skin-electrode- impedance (ESEI) measurements was carried out for the dry electrodes by
impedance spectroscopy. The biopotential signals are processed using an instrumentation amplifier with high CMRR and
high input impedance achieved by boot strapping the input terminals. The signals are band limited by means of a second
order Butterworth band pass filters to eliminate noise. The processed biopotential signals are digitized and transmitted
wirelessly to a remote monitoring station.
Traditionally, home care for chronically ill patients and the elderly requires periodic visits to the patient's
home by doctors or healthcare personnel. During these visits, the visiting person usually records the
patient's vital signs and takes decisions as to any change in treatment and address any issues that the patient
may have. Patient monitoring systems have since changed this scenario by significantly reducing the
number of home visits while not compromising on continuous monitoring. This paper describes the design
and development of a patient monitoring systems capable of concurrent remote monitoring of 8 patient-worn
sensors: Electroencephalogram (EEG), Electrocardiogram (ECG), temperature, airflow pressure,
movement and chest expansion. These sensors provide vital signs useful for monitoring the health of
chronically ill patients and alerts can be raised if certain specified signal levels fall above or below a preset
threshold value. The data from all eight sensors are digitally transmitted to a PC or to a standalone network
appliance which relays the data through an available internet connection to the remote monitoring client.
Thus it provides a real-time rendering of the patient's health at a remote location.
The brain and the human nervous system are perhaps the most researched but least understood components of the
human body. This is so because of the complex nature of its working and the high density of functions. The monitoring
of neural signals could help one better understand the working of the brain and newer recording and monitoring
methods have been developed ever since it was discovered that the brain communicates internally by means of electrical
pulses. Neural signal communication is achieved by the production and propagation of small electrical signals produced
by the nerve cells called neurons. Neuroelectronics is the field which deals with the interface between electronics or
semiconductors to living neurons. This includes monitoring of electrical activity from the brain as well as the
development of feedback devices for stimulation of parts of the brain for treatment of disorders. This paper reviews the
basic principles of Neuroelectronics which are used to develop several applications ranging from diagnostic tools to
brain-computer interfaces, neural stimulation and several others.
The design and development of wireless mocrosensor network systems for the treatment of many degenerative as well as traumatic neurological disorders is presented in this paper. Due to the advances in micro and nano sensors and wireless systems, the biomedical sensors have the potential to revolutionize many areas in healthcare systems. The integration of nanodevices with neurons that are in communication with smart microsensor systems has great potential in the treatment of many neurodegenerative brain disorders. It is well established that patients suffering from either Parkinson’s disease (PD) or Epilepsy have benefited from the advantages of implantable devices in the neural pathways of the brain to alter the undesired signals thus restoring proper function. In addition, implantable devices have successfully blocked pain signals and controlled various pelvic muscles in patients with urinary and fecal incontinence. Even though the existing technology has made a tremendous impact on controlling the deleterious effects of disease, it is still in its infancy. This paper presents solutions of many problems of today's implantable and neural-electronic interface devices by combining nanowires and microelectronics with BioMEMS and applying them at cellular level for the development of a total wireless feedback control system. The only device that will actually be implanted in this research is the electrodes. All necessary controllers will be housed in accessories that are outside the body that communicate with the implanted electrodes through tiny inductively-coupled antennas. A Parkinson disease patient can just wear a hat-system close to the implantable neural probe so that the patient is free to move around, while the sensors continually monitor, record, transmit all vital information to health care specialist. In the event of a problem, the system provides an early warning to the patient while they are still mobile thus providing them the opportunity to react and trigger the feed back system or contact a point-of-care office that can remotely control the implantable system. The remote monitoring technology can be adaptable to EEG monitoring of children with epilepsy, implantable cardioverters/defibrillators, pacemakers, chronic pain management systems, treatment for sleep disorders, patients with implantable devices for diabetes. In addition, the development of a wireless neural electronics interface to detect, transmit and analyze neural signals could help patients with spinal injuries to regain some semblance of mobile activity.
Epilepsy is a form of brain disorder caused by abnormal discharges of neurons. The most common manifestations of epilepsy are seizures which could affect visual, aural and motor abilities of a person. Absence epilepsy is a form of epilepsy common mostly in children. The most common manifestations of absence epilepsy are staring and transient loss of responsiveness. Also, subtle motor activities may occur. Due to the subtle nature of these symptoms, episodes of absence epilepsy may often go unrecognized for long periods of time or be mistakenly attributed to attention deficit disorder or daydreaming. Spells of absence epilepsy may last about 10 seconds and occur hundreds of times each day. Patients have no recollections of the events occurred during those seizures and will resume normal activity without any postictal symptoms. The EEG during such episodes of Absence epilepsy shows intermittent activity of 3 Hz generalized spike and wave complexes. As EEG is the only way of detecting such symptoms, it is required to monitor the EEG of the patient for a long time, usually the whole day. This requires that the patient be connected to the EEG recorder all the time and thus remain only in the bed. So, effectively the EEG is being monitored only when the patient is stationary. The wireless monitoring system described in this paper aims at eliminating this constraint and enables the physician to monitor the EEG when the patient resumes his normal activities. This approach could even help the doctor identify possible triggers of absence epilepsy.
Hypoglycemia-abnormal decrease in blood sugar-is a major obstacle in the management of diabetes and prevention of long-term complications, and it may impose serious effects on the brain, including impairment of memory and other cognitive functions. This paper presents the development of a non-invasive sensor with miniaturized telemetry device in a wrist-watch for monitoring glucose concentration in blood. The sensor concept is based on optical chirality of glucose level in the interstitial fluid. The wrist watch consists of a laser power source of the wavelength compatible with the glucose. A nanofilm with specific chirality is placed at the bottom of the watch. The light then passes through the film and illuminates a small area on the skin. It has been documented that there is certain concentration of sugar level is taken by the intertitial fluid from the blood stream and deposit a portion of it at the dead skin. The wrist-watch when in contact with the outer skin of the human will thus monitor the glucose concentration. A wireless monitoring system in the watch then downloads the data from the watch to a Palm or a laptop computer.
This paper presents the development of a Bluetooth enabled wireless tuning fork gyroscope for the biomedical applications, including gait phase detection system, human motion analysis and physical therapy. This gyroscope is capable of measuring rotation rates between -90 and 90 and it can read the rotation information using a computer. Currently, the information from a gyroscope can trigger automobile airbag deployment during rollover, improve the accuracy and reliability of GPS navigation systems and stabilize moving platforms such as automobiles, airplanes, robots, antennas, and industrial equipment. Adding wireless capability to the existing gyroscope could help to expand its applications in many areas particularly in biomedical applications, where a continuous patient monitoring is quite difficult. This wireless system provides information on several aspects of activities of patients for real-time monitoring in hospitals.
This paper presents an overview of the wireless monitoring and quantitative assessment of joint dynamics of ankle which has suffered from soft tissue injury, immobilization or any dysfunction with special focus on the treatment and rehabilitation applications. The inadequacy of a reliable and easy method for continuous measurement and recording of ankle movement while doing physical therapy makes the monitoring of its progress difficult. Development of a wireless ankle motion monitoring system inside the shoe provides information on several aspects of activities associated with a dysfunctional foot. The system is based on continuous wireless monitoring of signals from accelerometers and gyroscopes fixed inside the shoe. From these signals, the duration, rate, and moment of occurrence of activities associated with mobility (e.g., lying, sitting, standing, walking up and down, running, cycling, wheelchair use and general movement) and transitions (changes in angle) can be detected. Information about the movement can be obtained by the acceleration sensors, which is related to the intensity of body-segment movement. Apart from monitoring accelerations, other signals due to turning and angular movements can be obtained using the miniature gyroscope attached to the shoe.
Hypoglycemia-abnormal decrease in blood sugar- is a major obstacle in the management of diabetes and prevention of long-term complications, and it may impose serious effects on the brain, including impairment of memory and other cognitive functions. This is especially a concern in early childhood years when the nervous system is still developing. Hypoglycemic unawareness (in which the body’s normal ability to signal low blood sugar doesn’t work and an oncoming low blood sugar episode proceeds undetected) is a particularly frightening problem for many people with diabetes. Researchers have now uncovered evidence that repeated bouts of insulin-induced hypoglycemia can harm the brain over time, causing confusion, abnormal behavior, loss of consciousness, and seizures. Extreme cases have resulted in coma and death. In this paper, a non-invasive biosensor in a wrist watch along with a wireless data downloading system is proposed.
Absence epilepsy is a form of epilepsy common mostly in children. The most common manifestations of Absence epilepsy are staring and transient loss of responsiveness. Also, subtle motor activities may occur. Due to the subtle nature of these symptoms, episodes of absence epilepsy may often go unrecognized for long periods of time or be mistakenly attributed to attention deficit disorder or daydreaming. Spells of absence epilepsy may last about 10 seconds and occur hundreds of times each day. Patients have no recollections of the events that occurred during those seizures and will resume normal activity without any postictal symptoms. The EEG during such episodes of Absence epilepsy shows intermittent activity of 3 Hz generalized spike and wave complexes. As EEG is the only way of detecting such symptoms, it is required to monitor the EEG of the patient for a long time and thus remain only in bed. So, effectively the EEG is being monitored only when the patient is stationary. The wireless monitoring sys tem described in this paper aims at eliminating this constraint and enables the physicial to monitor the EEG when the patient resumes his normal activities. This approach could even help the doctor identify possible triggers of absence epilepsy.
Hypoglycemia - abnormal decrease in blood sugar - is a major obstacle in the management of diabetes and prevention of long-term complications, and it may impose serious effects on the brain, including impairment of memory and other cognitive functions. This paper presents the development of a non-invasive sensor with miniaturized telemetry device in a wrist-watch for monitoring glucose concentration in blood. The sensor concept is based on optical chiralit of glucose level in the interstitial fluid. The wrist watch consists of a laser power source of the wavelength compatible with the glucose. A nanofilm with specific chirality is placed at the bottom of the watch. The light then passes through the film and illuminates a small area on the skin.It has been documented that there is certain concentration of sugar level is taken by the intertitial fluid from the blood stream and deposit a portion of it at the dead skin. The wrist-watch when in contact with the outer skin of the human will thus monitor the glucose concentration. A wireless monitoring system in the watch then downloads the data from the watch to a Palm or laptop computer.
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