Photothermal therapy offers a solution for the destruction of cancer cells without significant collateral damage to
otherwise healthy cells. Several attempts are underway in using carbon nanoparticles (CNPs) and nanotubes due to their
excellent absorption properties in the near-infrared spectrum of biological window. However, minimizing the required
number of injected nanoparticles, to ensure minimal cytotoxicity, is a major challenge. We report on the introduction of
magnetic carbon nanoparticles (MCNPs) onto cancer cells, localizing them in a desired region by applying an external
magnetic field and irradiating them with a near-infrared laser beam. The MCNPs were prepared in Benzene, using an
electric plasma discharge, generated in the cavitation field of an ultrasonic horn. The CNPs were made ferromagnetic by
use of Fe-electrodes to dope the CNPs, as confirmed by magnetometry. Transmission electron microscopy measurements
showed the size distribution of these MCNPs to be in the range of 5-10 nm. For photothermal irradiation, a tunable
continuous wave Ti: Sapphire laser beam was weakly focused on to the cell monolayer under an inverted fluorescence
microscope. The response of different cell types to photothermal irradiation was investigated. Cell death in the presence
of both MCNPs and laser beam was confirmed by morphological changes and propidium iodide fluorescence inclusion
assay. The results of our study suggest that MCNP based photothermal therapy is a promising approach to remotely
guide photothermal therapy.
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