Dr. Barry Vuong Profile

Dr. Barry Vuong

Senior Scientist \ Engineer

SPIE Involvement:

Author

Publications (24)

Proceedings Article | 7 March 2022 Presentation

Presentation

Feasibility and safety of tethered capsule endomicroscopy in studying the natural history of Barrett’s esophagus: a multi-center study

Jing Dong, Catriona Grant, Barry Vuong, Norman Nishioka, Anna Huizi Gao, Matthew Beatty, Grace Baldwin, Aaron Bailargeon, Ara Bablouzian, Patricia Grahmann, Nitasha G. Bhat, Emily Ryan, Amilcar Barrios, Paola Leon Alarcon, Sarah Giddings, Tim Ford, Émilie Beaulieu-Ouellet, Seyed Hamid Hosseiny, Irene Lerman, Wolfgang Trasischker, Rohith Reddy, Kanwarpal Singh, Michalina Gora, Daryl Hyun, Lucille Quénéhervé, Michael Wallace, Wolfsen Herbert, Prateek Sharma, Kenneth Wang, Cadman Leggett, John Poneros, Julian Abrams, Charles Lightdale, Samantha Leeds, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume PC11937, PC119370N (2022) https://doi.org/10.1117/12.2610595

KEYWORDS: Esophagus, Optical coherence tomography, Endoscopy, Endomicroscopy, Safety, Tissues, Imaging systems, Biopsy, Diagnostics, Yield improvement

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Proceedings Article | 4 March 2019 Presentation

Presentation

Natural history of Barrett’s esophagus using tethered capsule OCT endomicroscopy and portable OCT imaging system: initial experience (Conference Presentation)

Jing Dong, Barry Vuong, Timothy Ford, Matthew Beatty, Seyed Hamid Hosseiny, Emilie Beaulieu-Ouellet, Rohith Reddy, Kanwarpal Singh, Hany Osman, Catriona Grant, Anna Huizi Gao, Samantha Leeds, Norman Nishioka, John Poneros, Julian Abrams, Charles Lightdale, Prateek Sharma, Michael Wallace, Herbert Wolfsen, Kenneth Wang, Cadman Leggett, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10867, 108670T (2019) https://doi.org/10.1117/12.2511523

KEYWORDS: Optical coherence tomography, Esophagus, Imaging systems, Endomicroscopy, Endoscopy, Biopsy, 3D image processing, Clinical trials, Image resolution, Tissues

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While the most common method used to evaluate and survey patients with Barrett’s Esophagus (BE) is endoscopic biopsy, this procedure is invasive, time-consuming, and suffers from sampling errors. Moreover, it requires patient sedation that increases cost and mandates its operation in specialized settings. Our lab has developed a new imaging tool termed tethered capsule endomicroscopy (TCE) that involves swallowing a tethered capsule which utilizes optical coherence tomography (OCT) to obtain three-dimensional microscopic (10µm) images of the entire esophageal wall as it traverses the luminal organ via peristalsis or is retrieved by pulling up tether. As opposed to endoscopy, TCE procedure is non-invasive, doesn’t require patient sedation and mitigates sampling error by evaluating the microscopic structure of the entire esophagus. The merits of TCE make it a suitable device to investigate the microscopic natural history of BE in a longitudinal manner. Here, we present our initial experience of a multicenter (5-site) clinical trial to study the microscopic natural history of BE. The TCE device used for the study is the new generation capsule with the ball lens optical configuration and a distal scan stepper motor, which provides 30µm (lateral) resolution and 40Hz imaging rate. The portable OCT imaging system is a custom in-house built swept source system and provides 7µm (axial) at a 100 kHz A-line rate with a center wavelength of ~1310 nm. To date, we have successfully enrolled 69 subjects at all sites (MGH: 33, Columbia University: 11, Kansas City VA: 10, Mayo Jacksonville: 8, Mayo Rochester: 7) and 59 have swallowed the capsule (85.5%). There have been no reported adverse events associated with TCE procedure. High-quality OCT images were reliably obtained from patients who swallowed the device, and BE tissues were identified by expert readers. Our initial experience with TCE in a multicenter study demonstrates that this technology is easy to use and efficient in multiple clinical settings. Completion of this longitudinal study is likely to provide new insights on the temporal progression of BE that may impact management strategies.

Proceedings Article | 14 March 2018 Presentation

Presentation

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 10470, 104700X (2018) https://doi.org/10.1117/12.2287843

KEYWORDS: Laser marking, Optical coherence tomography, Endomicroscopy, Endoscopy, Laser optics, Coherence (optics), Esophagus, Cancer, Surveillance, Diagnostics

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Proceedings Article | 19 April 2017 Presentation

Presentation

A coaxially focused multi-mode beam for optical coherence tomography imaging with extended depth of focus (Conference Presentation)

Biwei Yin, Chia-Pin Liang, Barry Vuong, Guillermo Tearney

Proceedings Volume 10053, 100531N (2017) https://doi.org/10.1117/12.2254928

KEYWORDS: Coherence imaging, Optical imaging, Optical coherence tomography, Gaussian beams, Laser beam diagnostics, Fiber optics, Image resolution, Wavefronts, Confocal microscopy, Range imaging

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Proceedings Article | 19 April 2017 Presentation

Presentation

Assessment of hemodynamics of intracranial aneurysms using Doppler optical coherence tomography in patient specific phantoms: preliminary results (Conference Presentation)

Joel Ramjist, Jamil Jivraj, Dexter Barrows, Barry Vuong, Ronnie Wong, Victor X. Yang

Proceedings Volume 10050, 100500M (2017) https://doi.org/10.1117/12.2256532

KEYWORDS: Neurophotonics, Hemodynamics, Optical coherence tomography, Doppler tomography, Computational fluid dynamics, High speed cameras, Therapeutics, Pathology, Computer simulations, Device simulation

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Proceedings Article | 19 April 2017 Presentation

Presentation

Graphics processor unit acceleration enables realtime endovascular Doppler optical coherence tomography imaging: development and validation (Conference Presentation)

Dexter Barrows, Joel Ramjist, Barry Vuong, Kenneth Lee, Jamil Jivraj, Victor X. Yang

Proceedings Volume 10050, 100500W (2017) https://doi.org/10.1117/12.2256623

KEYWORDS: Optical coherence tomography, Doppler tomography, Coherence imaging, Image processing, Blood, Visualization, Optical imaging, Pathology, Blood circulation, Skin

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Proceedings Article | 19 April 2017 Presentation

Presentation

Extended depth of focus tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging (Conference Presentation)

Barry Vuong, Biwei Yin, Emilie Beaulieu-Ouellet, Chia Pin Liang, Matthew Beatty, Kanwarpal Singh, Jing Dong, Catriona Grant, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10040, 100400N (2017) https://doi.org/10.1117/12.2252103

KEYWORDS: Photomedicine, Optical coherence tomography, Endoscopy, Tissue optics, Endomicroscopy, Esophagus, Image resolution, Tissues, Imaging devices, Optomechanical components

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Endoscopy, the current standard of care for the diagnosis of upper gastrointestinal (GI) diseases, is not ideal as a screening tool because it is costly, necessitates a team of medically trained personnel, and typically requires that the patient be sedated. Endoscopy is also a superficial macroscopic imaging modality and therefore is unable to provide detailed information on subsurface microscopic structure that is required to render a precise tissue diagnosis. We have overcome these limitations through the development of an optical coherence tomography tethered capsule endomicroscopy (OCT-TCE) imaging device. The OCT-TCE device has a pill-like form factor with an optically clear wall to allow the contained opto-mechanical components to scan the OCT beam along the circumference of the esophagus. Once swallowed, the OCT-TCE device traverses the esophagus naturally via peristalsis and multiple cross-sectional OCT images are obtained at 30-40 μm lateral resolution by 7 μm axial resolution. While this spatial resolution enables differentiation of squamous vs columnar mucosa, crucial microstructural features such as goblet cells (~10 μm), which signify intestinal metaplasia in BE, and enlarged nuclei that are indicative of dysplasia cannot be resolved with the current OCT-TCE technology. In this work we demonstrate a novel design of a high lateral resolution OCT-TCE device with an extended depth of focus (EDOF). The EDOF is created by use of self-imaging wavefront division multiplexing that produces multiple focused modes at different depths into the sample. The overall size of the EDOF TCE is similar to that of the previous OCT-TCE device (~ 11 mm by 26 mm) but with a lateral resolution of ~ 8 μm over a depth range of ~ 2 mm. Preliminary esophageal and intestinal imaging using these EDOF optics demonstrates an improvement in the ability to resolve tissue morphology including individual glands and cells. These results suggest that the use of EDOF optics may be a promising avenue for increasing the accuracy of OCT-TCE for the diagnosis of upper GI diseases.

Proceedings Article | 17 February 2017 Paper

Paper

Graphics processor unit acceleration enables realtime endovascular Doppler optical coherence tomography imaging

Dexter Barrows, Barry Vuong, Kenneth Lee, Jamil Jivraj, Victor Yang

Proceedings Volume 10053, 100532G (2017) https://doi.org/10.1117/12.2254930

KEYWORDS: Optical coherence tomography, Doppler tomography, Coherence imaging, Blood, Visualization, Optical imaging, Pathology, Blood circulation, Skin, Eye, Image processing, Doppler effect, Computing systems, Imaging systems

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Proceedings Article | 10 March 2015 Paper

Paper

Evaluation of hemodynamics changes during interventional stent placement using Doppler optical coherence tomography

Barry Vuong, Helen Genis, Ronnie Wong, Joel Ramjist, Jamil Jivraj, Hamza Farooq, Cuiru Sun, Victor Yang

Proceedings Volume 9305, 93050Q (2015) https://doi.org/10.1117/12.2080635

KEYWORDS: Optical coherence tomography, Hemodynamics, In vivo imaging, Independent component analysis, Arteries, Blood circulation, Doppler tomography, Computational fluid dynamics, 3D modeling, Doppler effect

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Proceedings Article | 10 March 2015 Paper

Paper

Spinal cord deformation due to nozzle gas flow effects using optical coherence tomography

Ronnie Wong, Jamil Jivraj, Barry Vuong, Joel Ramjist, Cuiru Sun, Yize Huang, Victor Yang

Proceedings Volume 9305, 93050A (2015) https://doi.org/10.1117/12.2080607

KEYWORDS: Chemical species, Stars, Spinal cord, Eye, Optical telescopes, Composites, Nitrogen, Oxygen, Optical coherence tomography, Image processing

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Proceedings Article | 10 March 2015 Paper

Paper

Coaxial cavity injected OCT and fiber laser ablation system for real-time monitoring of ablative processes

Jamil Jivraj, Yize Huang, Ronnie Wong, Yi Lu, Barry Vuong, Joel Ramjist, Xijia Gu, Victor Yang

Proceedings Volume 9305, 930505 (2015) https://doi.org/10.1117/12.2080606

KEYWORDS: Optical coherence tomography, Fiber lasers, Laser ablation, Imaging systems, Linear filtering, Sensors, Laser systems engineering, Eye, Brain, Cameras

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Proceedings Article | 9 March 2015 Paper

Paper

Development of a low cost, 3-DOF desktop laser cutter using 3D printer hardware

Jamil Jivraj, Yize Huang, Ronnie Wong, Yi Lu, Barry Vuong, Joel Ramjist, Xijia Gu, Victor Yang

Proceedings Volume 9356, 93560N (2015) https://doi.org/10.1117/12.2080629

KEYWORDS: 3D printing, Head, Computer aided design, Laser cutting, Printing, Switches, Metals, 3D imaging standards, Fluctuations and noise, Fiber lasers

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Proceedings Article | 2 March 2015 Paper

Paper

Application of optical coherence tomography attenuation imaging for quantification of optical properties in medulloblastoma

Barry Vuong, Patryk Skowron, Tim-Rasmus Kiehl, Matthew Kyan, Livia Garzia, Helen Genis, Cuiru Sun, Michael Taylor, Victor Yang

Proceedings Volume 9312, 93122Z (2015) https://doi.org/10.1117/12.2080642

KEYWORDS: Optical coherence tomography, Signal attenuation, Tissue optics, Tumors, Coherence imaging, Brain, Cerebellum, Optical properties, Biomedical optics, Tissues

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SPIE Journal Paper | 20 August 2014 Open Access

Open Access

Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

Kyle Cheng, Adrian Mariampillai, Kenneth Lee, Barry Vuong, Timothy Luk, Joel Ramjist, M. Anne Curtis, Henry Jakubovic, Peter Kertes, Michelle Letarte, Marie Faughnan, Victor Yang

JBO, Vol. 19, Issue 08, 086015, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086015

KEYWORDS: Optical coherence tomography, Skin, Speckle, Tissues, In vivo imaging, Angiography, Brain, Blood vessels, Image processing, Tissue optics

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Proceedings Article | 26 February 2014 Paper

Paper

Imaging of electro-kinetic properties of tissue using the amplitude and the phase of optical coherence tomography

V. Toronov, V. Demidov, Y. Xu, B. Vuong, C. Sun, V. X. Yang, I. Vitkin

Proceedings Volume 8942, 89420X (2014) https://doi.org/10.1117/12.2043179

KEYWORDS: Optical coherence tomography, Tissues, Tissue optics, Algorithm development, Image processing, MATLAB, Electrodes, Fourier transforms, Smoothing, Natural surfaces

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SPIE Journal Paper | 17 December 2013 Open Access

Open Access

Digital image correlation–based optical coherence elastography

Cuiru Sun, Beau Standish, Barry Vuong, Xiao-Yan Wen, Victor X. Yang

JBO, Vol. 18, Issue 12, 121515, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.121515

KEYWORDS: Optical coherence tomography, Digital image correlation, Tissues, Speckle, Elastography, Coherence (optics), Tissue optics, Speckle pattern, Biomedical optics, Image compression

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Proceedings Article | 18 June 2013 Paper

Paper

Preliminary study of digital image correlation based optical coherence elastography

Cuiru Sun, Barry Vuong, Xiao-Yan Wen, Victor Yang

Proceedings Volume 8802, 880207 (2013) https://doi.org/10.1117/12.2033256

KEYWORDS: Optical coherence tomography, Tissue optics, Digital image correlation, Elastography, Coherence (optics), Soft tissue optics, Tissues, Image compression, Biomedical optics, Calibration

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SPIE Journal Paper | 24 April 2013 Open Access

Open Access

Review of speckle and phase variance optical coherence tomography to visualize microvascular networks

Mohammad Mahmud, David Cadotte, Barry Vuong, Carry Sun, Timothy Luk, Adrian Mariampillai, Victor X. Yang

JBO, Vol. 18, Issue 05, 050901, (April 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.050901

KEYWORDS: Optical coherence tomography, Speckle, Tissues, Doppler tomography, Blood vessels, Visualization, Imaging systems, Tumors, Capillaries, Image processing

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Proceedings Article | 20 March 2013 Paper

Paper

Imaging of electro-kinetic responses of tissues with optical coherence tomography

V. Demidov, V. Toronov, Y. Xu, B. Vuong, C. Sun, V. X. Yang, A. Vitkin

Proceedings Volume 8571, 85712Q (2013) https://doi.org/10.1117/12.2005910

KEYWORDS: Optical coherence tomography, Tissues, Signal processing, Image processing, Optical fibers, Tissue optics, MATLAB, Solids, Light sources, Natural surfaces

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Proceedings Article | 8 March 2013 Paper

Paper

Blood flow velocity measurement by endovascular Doppler optical coherence tomography

Cuiru Sun, Felix Nolte, Barry Vuong, Kyle H. Cheng, Kenneth K. Lee, Beau Standish, Brian Courtney, Tom Marotta, Victor X. Yang

Proceedings Volume 8565, 85654S (2013) https://doi.org/10.1117/12.2019244

KEYWORDS: Blood circulation, Optical coherence tomography, Doppler tomography, Arteries, In vivo imaging, Velocity measurements, Blood vessels, Doppler effect, Phase shifts, Data acquisition

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Proceedings Article | 18 February 2012 Paper

Paper

Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study

Barry Vuong, Cuiru Sun, Tim-Rasmus Khiel, Joseph Gardecki, Beau Standish, Leodante da Costa, Josaphat de Morais, Guillermo Tearney, Victor X. Yang

Proceedings Volume 8207, 82074M (2012) https://doi.org/10.1117/12.908998

KEYWORDS: Optical coherence tomography, Tissues, Coherence imaging, Tissue optics, Optical imaging, Calcium, Arteries, Pathology, Visualization, Imaging systems

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Proceedings Article | 9 February 2012 Paper

Paper

Neurosurgical hand-held optical coherence tomography (OCT) forward-viewing probe

Cuiru Sun, Kenneth K. Lee, Barry Vuong, Michael Cusimano, Alexander Brukson, Adrian Mariampillai, Beau Standish, Victor X. Yang

Proceedings Volume 8207, 82074V (2012) https://doi.org/10.1117/12.909116

KEYWORDS: Optical coherence tomography, Imaging systems, Tumors, Doppler effect, Doppler tomography, Blood circulation, GRIN lenses, Blood vessels, Coherence imaging, Tissue optics

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Proceedings Article | 17 February 2010 Paper

Paper

Cascaded Raman fiber laser in Fourier domain mode lock operation

Barry Vuong, Mark Harduar, Kyle H. Cheng, Xijia Gu, Lawrence Chen, Beau Standish, Victor X. Yang

Proceedings Volume 7580, 75802R (2010) https://doi.org/10.1117/12.842769

KEYWORDS: Raman spectroscopy, Fiber lasers, Fiber Bragg gratings, Quantum cascade lasers, Optical filters, Mirrors, Optical coherence tomography, Laser sources, Ytterbium, Optical testing

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Proceedings Article | 17 February 2010 Paper

Paper

Dual core ytterbium doped fiber ring laser in Fourier domain mode locked operation for swept-source optical coherence tomography

Mark Harduar, Adrian Mariampillai, Barry Vuong, Kyle H. Cheng, Lawrence Chen, Xijia Gu, Beau Standish, Victor X. Yang

Proceedings Volume 7580, 75802S (2010) https://doi.org/10.1117/12.842825

KEYWORDS: Ytterbium, Optical coherence tomography, Fiber lasers, Optical filters, Fiber amplifiers, Mode locking, Optical amplifiers, Laser sources, Electronic filtering, Absorption

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Showing 5 of 24 publications

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