This work relies on the development of a sensorized medical needle with an all-optical guidance (Lab in a Needle)
system for epidural space identification. The device is based on the judicious integration of a Fiber Bragg grating sensor
inside the lumen of an epidural needle to discriminate between different types of tissue and thus providing continuous
and real time measurements of the pressure experienced by the needle tip during its advancement. Experiments carried
out on an epidural training phantom demonstrate the validity of our approach for the correct and effective identification
of the epidural space.
This work deals with a novel Lab-on-Fiber biosensor able to detect in real time thyroid carcinomas biomarkers. The device is based on a gold nanostructure supporting localized surface plasmon resonances (LSPR) directly fabricated on the fiber tip by means of electron beam lithography and lift-off process. Following a suitable chemical and biological functionalization of the sensing area, human Thyroglobulin has been detected at nanomolar concentrations. Also, compatibility with full baseline restoration, achieved through biomarkers/bioreceptors dissociation, has been demonstrated.