Dr. Bing Zhang Profile

Dr. Bing Zhang

at Zhejiang Univ

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Publications (3)

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Proceedings Article | 13 April 2019 Presentation + Paper

Axial spatial refractive index distribution of surface plasmon resonance sensor based on multi-wavelength angular interrogation structure

Yi Sun, Haoyuan Cai, Xin Qiao, Bing Zhang, Shuyue Zhan, Xiaoping Wang

Proceedings Volume 11028, 1102811 (2019) https://doi.org/10.1117/12.2524655

KEYWORDS: Refractive index, Particle swarm optimization, Surface plasmons, Interfaces, Spatial resolution, Biological research, Gold, Particles, Sensors, Analytical research

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Surface plasmon resonance (SPR) sensing technology is widely used in the field of biosensors due to its non-marking, high-sensitivity, and non-invasive characteristics. However, SPR technology is still limited to sensing analysis in twodimensional plane, axial detection, as the key of SPR application in three-dimensional medium spatial detection, has not been well studied and solved. In an angle-interrogation SPR sensing system, the spatial characteristics of evanescent wave-dielectric interaction at multiple wavelengths are studied, and the factors affecting the spatial distribution of surface plasmon resonance are also analyzed. An axial spatial resolution method based on the particle swarm optimization (PSO) algorithm with multi-wavelength angle-interrogation structure is proposed, the refractive index distribution in axial space is determined by analyzing the characteristic SPR signal. In addition, the calculation and analysis of the applicable range of wavelengths are carried out. In the reliable spectral range of the incident light wavelength of 600-900 nm, the average error of the axial refractive index spatial resolution increases from 10^-5 RIU to 10^-4 RIU as the number of axial layers increases. The proposed multi-wavelength angle modulation structure analysis method based on PSO algorithm extends the SPR detection range from two-dimensional plane to three-dimensional space, which provides a new and promising analysis model for molecular biology.

Proceedings Article | 5 September 2018 Paper

High-peformance bimetallic SPR sensor for ciprofloxacin based on molecularly imprinted polymer

Bing Zhang, Yi Sun, Kai Pang, Xiaoping Wang

Proceedings Volume 10728, 107280N (2018) https://doi.org/10.1117/12.2320083

KEYWORDS: Sensors, Polymers, Molecules, Refractive index, Dielectrics, Surface plasmons

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A bimetallic chip was designed to improve the performance of a surface plasmon resonance (SPR) sensor based on angular interrogation, which demonstrated a relatively low noise level and a high resolution compared with a single gold chip. The calculated refractive index resolution of the bimetallic chip is 5.3 × 10^-7 RIU. In addition, the electric field intensity at the surface of the chip is enhanced. This can guarantee a high sensitivity in a larger sensing region for the measurement of macromolecules, especially in the field of biological sensing. The bimetallic chip SPR sensor was combined with molecularly imprinted polymer (MIP) film as artificial receptor to detect antibiotics. The molecularly imprinted polymer was prepared by photo-polymerization of ciprofloxacin capped with itaconic acid as functional monomer on the bimetallic chip. The thickness of the MIP film was 16 ±2 nm, which was measured with a stylus profiler. The MIP exhibited high selectivity to ciprofloxacin compared with dopamine and penicillin, and the selectivity coefficients of ciprofloxacin，penicillin, and dopamine were 1, 0.22, and 0.19, respectively. The SPR response was proportional to the concentration of ciprofloxacin, the limit of detection (LOD) of which was 0.1 pM or 0.04 ppt，while the LOD for a single gold chip was 0.5 pM. The adsorption of CIP by the MIP bimetallic-coated chip was reversible. Taking the reproducibility of MIP into consideration, a combination of SPR sensing with MIP is a promising method for the detection of ciprofloxacin.

Proceedings Article | 28 August 2015 Paper

A two-electrode electrochemical surface plasmon resonance sensor for investigating the electropolymerization of polyaniline

Bing Zhang, Yazhuo Li, Yizhang Wen, Peijun Cai, Xiaoping Wang

Proceedings Volume 9547, 95472P (2015) https://doi.org/10.1117/12.2187219

KEYWORDS: Electrodes, Sensors, Surface plasmons, Dielectrics, Polymers, Polymerization, Capacitance, Gold, Carbon, Oxidation

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A novel electrochemical surface plasmon resonance (EC-SPR) sensor has been developed based on the surface plasmon resonance (SPR) combined with a two-electrode electrochemical configuration. The theory of potential-modulated for EC-SPR was described, and several factors which can induce the change of the SPR resonance angle were revealed. Comparing with the conventional three-electrode electrochemical system, the reference electrode has been eliminated in this design, and the active carbon (AC) electrode employed as the counter electrode. Due to the large specific surface area, AC presents considerable double layer capacitance at the interface of electrode and electrolyte, which can provide a constant potential during the electrochemical reactions. Using an angle modulation SPR sensor and the resolution of that is 5x10^-6 RIU (refractive index units), a real-time data-smoothing algorithm is adopted to reduce the noise of the data, which can guarantee an accurate result of the resonance angle of SPR. The EC-SPR setup was used for investigating the electropolymerization of polyaniline by applying a potential of cyclic voltammetry, both of the electrochemical current and the resonance angle shift of SPR are recorded to monitor the growth process of the polymer. Comparing with the three-electrode configuration, the novel AC two-electrode system can also obtain detailed information about the polymerization process from the resonance angle shift curves, including the change of thickness and dielectric constant, deposition and transitions between different redox states of the polymer film. Experimental results demonstrated that this two-electrode EC-SPR configuration is suitable for analyzing the electropolymerization process of a conducting polymer.

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