Dr. Biwei Yin Profile

Dr. Biwei Yin

Optical System Scientist at Apple Inc.

SPIE Involvement:

Author

Publications (12)

Proceedings Article | 7 March 2019 Presentation

High-resolution micro-OCT for endothelial cell visualization in the coronary arteries (Conference Presentation)

Kensuke Nishimiya, Osman Ahsen, Biwei Yin, Zhonglie Piao, Jiheun Ryu, Hany Osman, Gargi Sharma, Hui Min Leung, Chia-Pin Liang, Joseph Gardecki, Guillermo Tearney

Proceedings Volume 10855, 1085502 (2019) https://doi.org/10.1117/12.2506264

KEYWORDS: Arteries, Visualization, Image segmentation, Scanning electron microscopy, Image resolution, Imaging technologies, Coherence (optics), Tomography, 3D image processing, Image processing

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Proceedings Article | 14 March 2018 Presentation

Dispersion estimation and compensation in optical coherence tomography (Conference Presentation)

Kanwarpal Singh, Gargi Sharma, Biwei Yin, Guillermo Tearney

Proceedings Volume 10486, 104860M (2018) https://doi.org/10.1117/12.2291336

KEYWORDS: Optical coherence tomography, Light sources, Signal to noise ratio, Silica

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Proceedings Article | 14 March 2018 Presentation

Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging (Conference Presentation)

Biwei Yin, Zhonglie Piao, Chulho Daryl Hyun, Kensuke Nishimiya, Joseph Gardecki, Guillermo Tearney

Proceedings Volume 10471, 104710B (2018) https://doi.org/10.1117/12.2288747

KEYWORDS: Optical coherence tomography, In vivo imaging, Arteries, Gaussian beams, Cardiovascular magnetic resonance imaging, Wavefronts, Endoscopy, Fiber optics, Visualization, Image resolution

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Proceedings Article | 20 April 2017 Paper

Towards a clinical implementation of uOCT instrument for in vivo imaging of human airways

Hui Min Leung, Dongyao Cui, Timothy Ford, Daryl Hyun, Jing Dong, Biwei Yin, Susan Birket, George Solomon, Linbo Liu, Steven Rowe, Guillermo Tearney

Proceedings Volume 10056, 1005614 (2017) https://doi.org/10.1117/12.2253423

KEYWORDS: Liquids, Pathogens, Human subjects, Imaging systems, Optical coherence tomography, Coherence (optics), Tomography, In vivo imaging, Cystic fibrosis, Image resolution

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Proceedings Article | 19 April 2017 Presentation

A coaxially focused multi-mode beam for optical coherence tomography imaging with extended depth of focus (Conference Presentation)

Biwei Yin, Chia-Pin Liang, Barry Vuong, Guillermo Tearney

Proceedings Volume 10053, 100531N (2017) https://doi.org/10.1117/12.2254928

KEYWORDS: Coherence imaging, Optical imaging, Optical coherence tomography, Gaussian beams, Laser beam diagnostics, Fiber optics, Image resolution, Wavefronts, Confocal microscopy, Range imaging

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Proceedings Article | 19 April 2017 Presentation

Imaging demonstration of a flexible micro-OCT endobronchial probe (Conference Presentation)

Dongyao Cui, Kengyeh Chu, Timothy Ford, Daryl Chulho Hyun, Hui Min Leung, Biwei Yin, Susan Birket, George Solomon, Steven Rowe, Guillermo Tearney

Proceedings Volume 10041, 1004109 (2017) https://doi.org/10.1117/12.2251449

KEYWORDS: Imaging systems, Photomedicine, Optical coherence tomography, Cystic fibrosis, Chronic obstructive pulmonary disease, In vivo imaging, Visualization, Motion models, Performance modeling, Imaging devices

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Proceedings Article | 19 April 2017 Presentation

Extended depth of focus tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging (Conference Presentation)

Barry Vuong, Biwei Yin, Emilie Beaulieu-Ouellet, Chia Pin Liang, Matthew Beatty, Kanwarpal Singh, Jing Dong, Catriona Grant, Mireille Rosenberg, Guillermo Tearney

Proceedings Volume 10040, 100400N (2017) https://doi.org/10.1117/12.2252103

KEYWORDS: Photomedicine, Optical coherence tomography, Endoscopy, Tissue optics, Endomicroscopy, Esophagus, Image resolution, Tissues, Imaging devices, Optomechanical components

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Endoscopy, the current standard of care for the diagnosis of upper gastrointestinal (GI) diseases, is not ideal as a screening tool because it is costly, necessitates a team of medically trained personnel, and typically requires that the patient be sedated. Endoscopy is also a superficial macroscopic imaging modality and therefore is unable to provide detailed information on subsurface microscopic structure that is required to render a precise tissue diagnosis. We have overcome these limitations through the development of an optical coherence tomography tethered capsule endomicroscopy (OCT-TCE) imaging device. The OCT-TCE device has a pill-like form factor with an optically clear wall to allow the contained opto-mechanical components to scan the OCT beam along the circumference of the esophagus. Once swallowed, the OCT-TCE device traverses the esophagus naturally via peristalsis and multiple cross-sectional OCT images are obtained at 30-40 μm lateral resolution by 7 μm axial resolution. While this spatial resolution enables differentiation of squamous vs columnar mucosa, crucial microstructural features such as goblet cells (~10 μm), which signify intestinal metaplasia in BE, and enlarged nuclei that are indicative of dysplasia cannot be resolved with the current OCT-TCE technology. In this work we demonstrate a novel design of a high lateral resolution OCT-TCE device with an extended depth of focus (EDOF). The EDOF is created by use of self-imaging wavefront division multiplexing that produces multiple focused modes at different depths into the sample. The overall size of the EDOF TCE is similar to that of the previous OCT-TCE device (~ 11 mm by 26 mm) but with a lateral resolution of ~ 8 μm over a depth range of ~ 2 mm. Preliminary esophageal and intestinal imaging using these EDOF optics demonstrates an improvement in the ability to resolve tissue morphology including individual glands and cells. These results suggest that the use of EDOF optics may be a promising avenue for increasing the accuracy of OCT-TCE for the diagnosis of upper GI diseases.

SPIE Journal Paper | 3 January 2014 Open Access

Degradation in the degree of polarization in human retinal nerve fiber layer

Biwei Yin, Bingqing Wang, Henry Rylander, Thomas Milner

JBO, Vol. 19, Issue 01, 016001, (January 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.1.016001

KEYWORDS: Polarization, Nerve, Birefringence, Optical coherence tomography, Advanced distributed simulations, Polarimetry, Poincaré sphere, Tissue optics, Single mode fibers, Jones vectors

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SPIE Journal Paper | 2 May 2013 Open Access

Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin, Roman Kuranov, Austin McElroy, S. M. Shams Kazmi, Andrew Dunn, Timothy Duong, Thomas Milner

JBO, Vol. 18, Issue 05, 056005, (May 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.056005

KEYWORDS: Blood, Optical coherence tomography, Blood circulation, Coherence imaging, Signal to noise ratio, Imaging systems, Blood vessels, Interference (communication), Oxygen, Oximeters

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Proceedings Article | 20 March 2013 Paper

Dual-wavelength photothermal optical coherence tomography for blood oxygen saturation measurement

Biwei Yin, Roman Kuranov, Austin McElroy, Thomas Milner

Proceedings Volume 8571, 857103 (2013) https://doi.org/10.1117/12.2006945

KEYWORDS: Blood, Optical coherence tomography, Imaging systems, Tissue optics, Diffusion, Mathematical modeling, Laser beam diagnostics, Modulation, Oximeters, Data modeling

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Proceedings Article | 30 January 2012 Paper

High-speed polarization sensitive optical coherence tomography for retinal diagnostics

Biwei Yin, Bingqing Wang, Kalyanramu Vemishetty, Jim Nagle, Shuang Liu, Tianyi Wang, Henry Rylander, Thomas Milner

Proceedings Volume 8213, 82132W (2012) https://doi.org/10.1117/12.911447

KEYWORDS: Polarization, Birefringence, Optical coherence tomography, Imaging systems, Eye, Field programmable gate arrays, Tissue optics, Diagnostics, Nerve, Computing systems

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Proceedings Article | 24 September 2011 Paper

Optimized retinal nerve fiber layer segmentation based on optical reflectivity and birefringence for polarization-sensitive optical coherence tomography

Bingqing Wang, Amit Paranjape, Biwei Yin, Shuang Liu, Mia Markey, Thomas Milner, H. Grady Rylander

Proceedings Volume 8135, 81351R (2011) https://doi.org/10.1117/12.892826

KEYWORDS: Birefringence, Image segmentation, Optical coherence tomography, Polarimetry, Nerve, Reflectivity, Polarization, Image processing algorithms and systems, Speckle, Detection and tracking algorithms

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Showing 5 of 12 publications

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