Mr. Bo Chen Profile

Bo Chen

Research assistant at Univ of Texas/Austin

SPIE Involvement:

Author

Publications (8)

Proceedings Article | 20 February 2008 Paper

Enhancement of light in tissue using hyper-osmotic agents

Raiyan Zaman, Bo Chen, Ashwin Parthasarathy, Arnold Estrada, Ardien Ponticorvo, Henry Rylander, Andrew Dunn, Ashley Welch

Proceedings Volume 6854, 68541F (2008) https://doi.org/10.1117/12.763241

KEYWORDS: Skin, Speckle, Blood circulation, Blood vessels, Arteries, Veins, Tissue optics, Doppler tomography, Blood, Capillaries

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Proceedings Article | 20 February 2008 Paper

Porcine skin ED50 damage thresholds for 1214 nm laser irradiation

Bo Chen, Jeffrey Oliver, Rebecca Vincelette, Ginger Pocock, Raiyan Zaman, Ashley Welch

Proceedings Volume 6854, 685406 (2008) https://doi.org/10.1117/12.761380

KEYWORDS: Skin, Laser damage threshold, Laser irradiation, Absorption, Tissues, Safety, Scattering, Tissue optics, Standards development, Injuries

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Proceedings Article | 21 February 2007 Paper

Damage threshold of in-vivo rabbit cornea by 2-um laser irradiation

Bo Chen, Jeffery Oliver, Soumak Dutta, Grady Rylander, Sharon Thomsen, Ashley Welch

Proceedings Volume 6435, 64350B (2007) https://doi.org/10.1117/12.701796

KEYWORDS: Laser damage threshold, Cornea, Safety, Infrared cameras, Laser irradiation, Cameras, Laser safety, Eye, Absorption, Lamps

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To support refinement of the Maximum Permissible Exposure (MPE) safety limits, a series of experiments were conducted in vivo on Dutch Belted rabbit corneas to determine corneal minimum visible lesion thresholds for 2.0 &mgr;m continuous-wave laser irradiation. Single pulse radiant exposures were made at specified pulse durations of 0.1 sec, 0.25 sec, 0.5 sec, 1.0 sec, 2.0 sec and 4.0 seconds for spot 1/e² diameters of 1.17 mm and 4.02 mm. Lesions were placed in rows without overlap on rabbit cornea. The effect of each irradiation was evaluated within one minute post exposure and the final determination of lesion formation was made using a slit lamp one hour post exposure. Threshold lesions were defined as the presence of a superficial surface whitening one hour after irradiation. Probit analysis was conducted to estimate the dose for 50% probability (ED50) of laser-induced damage. Approximately 20 different radiant exposures were made for each exposure duration-spot size combination. At the threshold level, the diameters of barely visible opaque white lesions were smaller than the Gaussian 1/e² beam diameter. In selected survival animals, most of the threshold lesions were still visible 24 hours after exposure. The average lesion radius was approximately 0.4 ± 0.12 mm diameter for the 1.17 mm spot size and 1.0 ± 0.20 mm diameter for the 4.02 mm spot size. The exposure duration dependence of threshold average radiant exposure was described by an empirical power law equation: Threshold radiant exposure[J/cm2] = a x exposure duration[s] ^b, experimentally derived coefficient a was 9.79 and b was 0.669 for the 1.17 mm spot diameter; values of a and b were 4.57 and 0.456 respectively for the 4.02 spot diameter. Based on the experimental data and the empirical power law, the safety factors which were defined as threshold radiant exposure divided by MPE values were predicted for the 2.0 &mgr;m wavelength at various exposure durations and spot diameters. The minimum limit of the safety factor was approximately a factor of four for both 4.02 mm and 1.17 mm spot diameters. Due to the very sharp boundary and small uncertainties of damage threshold determination, it is suggesting that a factor of 4 "padding" is adequate and safety standard may not need to be changed.

Proceedings Article | 8 February 2007 Paper

Histological study of skin damage by 2.0um laser irradiation

Bo Chen, Sharon Thomsen, Daniel O’Dell, Robert Thomas, Ashley Welch

Proceedings Volume 6440, 644004 (2007) https://doi.org/10.1117/12.700546

KEYWORDS: Skin, Laser irradiation, Inflammation, Collagen, Laser damage threshold, Birefringence, Blood vessels, Tissues, Injuries, Data modeling

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SPIE Journal Paper | 1 November 2006 Open Access

Modeling thermal damage in skin from 2000-nm laser irradiation

Bo Chen, Sharon Thomsen, Robert Thomas, Ashley Welch

JBO, Vol. 11, Issue 06, 064028, (November 2006) https://doi.org/10.1117/12.10.1117/1.2402114

KEYWORDS: Skin, Laser irradiation, Thermal modeling, Laser damage threshold, Temperature metrology, Standards development, Absorption, Tissue optics, Optical simulations, Tissues

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SPIE Journal Paper | 1 July 2006 Open Access

Using sandpaper for noninvasive transepidermal optical skin clearing agent delivery

O. Stumpp, Bo Chen, Ashley Welch

JBO, Vol. 11, Issue 04, 041118, (July 2006) https://doi.org/10.1117/12.10.1117/1.2340658

KEYWORDS: Skin, Tissue optics, Optical coherence tomography, In vivo imaging, Light scattering, Biomedical optics, Optical clearing, Tissues, Natural surfaces, Opacity

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SPIE Journal Paper | 1 July 2006 Open Access

Porcine skin visible lesion thresholds for near-infrared lasers including modeling at two pulse durations and spot sizes

Clarence Cain, Garrett Polhamus, William Roach, David Stolarski, Kurt Schuster, Kevin Stockton, Benjamin Rockwell, Bo Chen, Ashley Welch

JBO, Vol. 11, Issue 04, 041109, (July 2006) https://doi.org/10.1117/12.10.1117/1.2338815

KEYWORDS: Skin, Pulsed laser operation, Laser safety, Thermal modeling, Infrared cameras, Laser induced breakdown spectroscopy, Injuries, Standards development, Temperature metrology, Laser damage threshold

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Proceedings Article | 28 February 2006 Paper

Threshold damage of in vivo porcine skin at 2000 nm laser irradiation

Bo Chen, Daniel O'Dell, Sharon Thomsen, Benjamin Rockwell, Ashley Welch

Proceedings Volume 6084, 60840C (2006) https://doi.org/10.1117/12.639069

KEYWORDS: Skin, Laser damage threshold, Laser irradiation, Infrared cameras, Laser safety, Infrared imaging, Cameras, Injuries, Standards development, In vivo imaging

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Showing 5 of 8 publications

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