Prof. Brain C. Wilson Profile

Prof. Brain C. Wilson

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Proceedings Article | 23 October 2018 Paper

Optical fiber detection system for sensing singlet oxygen luminescence in aqueous solution

Lisheng Lin, Fuqiang Liang, Xuelin Xu, Huiyun Lin, Ying Gu, Brain Wilson, Buhong Li

Proceedings Volume 10820, 108202S (2018) https://doi.org/10.1117/12.2501151

KEYWORDS: Luminescence, Optical fibers, Oxygen, Photodynamic therapy, Signal to noise ratio, Signal detection, Sensing systems, Picosecond phenomena, Single photon detectors, Near infrared

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Singlet oxygen (¹O₂) is widely recognized as the primary cytotoxic agent during photodynamic therapy (PDT). The quantitation of ¹O₂ generation during PDT plays an important role for ¹O₂ based PDT dosimetry. However, it is still a challenging task for direct detection of ¹O₂ using an optical system due to its extremely weak luminescence at 1270 nm. In this paper, a highly sensitive optical fiber detection system was developed to measure the time-resolved ¹O₂ luminescence spectra from two model photosensitizers (Rose Bengal and TMPyP) at various concentrations (1.25, 2.5, 5.0, and 10.0 μM), The ¹O₂ luminescence signal was excited by a diode-pumped, Q-switched, frequency-doubled 523- nm Nd:YLF laser and collected by an optical fiber probe coupled with a highly sensitive NIR photomultiplier tube (PMT). Experimental results indicate that the ¹O₂ luminescence intensity shows a linear enhancement both with the increase of concentrations of Rose Bengal and TMPyP. The ¹O₂ luminescence signal dramatically decreased after the addition of 50 mM sodium azide, a specific ¹O₂ quencher. Furthermore, the signal-to-noise ratio (SNR), calculated under the condition of 10 mM Rose Bengal solution, is higher than those obtained from optical fiber ¹O₂ luminescence detection systems based on InGaAs/InP single photon avalanche diode and superconducting nanowire single-photon detector. Our results suggest that the home-built optical fiber system with a high sensitivity for ¹O₂ luminescence detection will have a great potential for clinical applications in PDT dosimetry.

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