Prof. Brian J. Bacskai Profile

Prof. Brian J. Bacskai

Associate Professor of Neurology at Massachusetts General Hospital

SPIE Involvement:

Author

SPIE Journal Paper | 1 July 2010 Open Access

Lifetime-based tomographic multiplexing

Scott Raymond, David Boas, Brian Bacskai, Anand Kumar

JBO, Vol. 15, Issue 04, 046011, (July 2010) https://doi.org/10.1117/12.10.1117/1.3469797

KEYWORDS: Tomography, Multiplexing, Picosecond phenomena, In vivo imaging, Luminescence, Near infrared, Liver, Imaging systems, Sensors

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SPIE Journal Paper | 1 November 2008 Open Access

Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons

William Stoothoff, Brian Bacskai, Bradley Hyman

JBO, Vol. 13, Issue 06, 064039, (November 2008) https://doi.org/10.1117/12.10.1117/1.3050422

KEYWORDS: Second-harmonic generation, Neurons, Axons, Signal processing, Signal detection, Harmonic generation, Polarizers, Proteins, Luminescence, Visualization

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SPIE Journal Paper | 1 January 2008 Open Access

Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy

Phill Jones, Aneta Rozkalne, Melanie Meyer-Luehmann, Tara Spires-Jones, Alexandra Makarova, Anand Kumar, Oksana Berezovska, Brian Bacskai, Bradley Hyman

JBO, Vol. 13, Issue 01, 014008, (January 2008) https://doi.org/10.1117/12.10.1117/1.2837169

KEYWORDS: Atrial fibrillation, Fluorescence lifetime imaging, Fluorescence resonance energy transfer, Proteins, Image segmentation, Microscopy, Luminescence, Neurons, Picosecond phenomena, Brain

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Proceedings Article | 1 March 2007 Paper

A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis

Scott Raymond, Brian Bacskai, Anand Kumar, David Boas

Proceedings Volume 6434, 64340E (2007) https://doi.org/10.1117/12.699692

KEYWORDS: Luminescence, Tomography, Absorption, Fluorescence tomography, Sensors, Tissue optics, Signal to noise ratio, Diffusion, Biomedical optics

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Proceedings Article | 13 February 2007 Paper

Fluorescence tomography in a murine model of Alzheimer’s disease

Brian Bacskai, David Boas, Andrew Dunn, Anand Kumar, Scott Raymond

Proceedings Volume 6434, 64342H (2007) https://doi.org/10.1117/12.700199

KEYWORDS: Photons, Brain, Absorption, Luminescence, Monte Carlo methods, Reflection, Alzheimer's disease, Quantum efficiency, Image segmentation, Head

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SPIE Journal Paper | 1 September 2006 Open Access

Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays

Phill Jones, Lauren Herl, Oksana Berezovska, Anand Kumar, Brian Bacskai, Bradley Hyman

JBO, Vol. 11, Issue 05, 054024, (September 2006) https://doi.org/10.1117/12.10.1117/1.2363367

KEYWORDS: Proteins, Fluorescence resonance energy transfer, Fluorescence lifetime imaging, Luminescence, Picosecond phenomena, Alzheimer's disease, Data modeling, Molecules, Signal attenuation, Drug discovery

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Proceedings Article | 22 November 2005 Paper

Time resolved fluorescence imaging in diffuse media

Andrew Dunn, Frank Hammond III, Jesse Skoch, David Boas, Anand T. Kumar, Brian Bacskai

Proceedings Volume 6009, 60090Y (2005) https://doi.org/10.1117/12.630990

KEYWORDS: Luminescence, Sensors, Modulation, Tissues, Absorption, Reconstruction algorithms, Diffusion, Imaging systems, Tomography, Biological research

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SPIE Journal Paper | 1 January 2005 Open Access

Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology

Jesse Skoch, Andrew Dunn, Bradley Hyman, Brian Bacskai

JBO, Vol. 10, Issue 01, 011007, (January 2005) https://doi.org/10.1117/12.10.1117/1.1846075

KEYWORDS: Brain, Near infrared, Neuroimaging, Positron emission tomography, Luminescence, Tissues, Pathology, Tissue optics, Radio optics, Alzheimer's disease

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Proceedings Article | 21 June 2004 Paper

In vivo multiphoton microscopy of deep tissue with gradient index lenses

Daniel Dombeck, Michael Levene, Bradley Hyman, Jochen Klucken, Gregory Hickey, Rebecca Williams, Jesse Skoch, Martin Ingelsson, Warren Zipfel, Edward Stern, Raymond Molloy, Watt Webb, Brian Bacskai, Karl Kasischke

Proceedings Volume 5323, (2004) https://doi.org/10.1117/12.537285

KEYWORDS: GRIN lenses, Multiphoton microscopy, In vivo imaging, Tissues, Ovary, Brain, Luminescence, Alzheimer's disease, Pathology, Lenses

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Proceedings Article | 21 June 2004 Paper

Multiphoton imaging in mouse models of Alzheimer's disease

Gregory Hickey, Brian Bacskai, Jesse Skoch, Oksana Berezovska, Bradley Hyman

Proceedings Volume 5323, (2004) https://doi.org/10.1117/12.537940

KEYWORDS: Brain, Proteins, Fluorescence lifetime imaging, Alzheimer's disease, Multiphoton microscopy, Luminescence, In vivo imaging, Fluorescence resonance energy transfer, Neuroimaging, Mouse models

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SPIE Journal Paper | 1 July 2003 Open Access

Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques

Brian Bacskai, Jesse Skoch, Gregory Hickey, Racquel Allen, Bradly Hyman

JBO, Vol. 8, Issue 03, (July 2003) https://doi.org/10.1117/12.10.1117/1.1584442

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Fluorescence lifetime imaging, Tissues, Proteins, Multiphoton fluorescence microscopy, Microscopes, Rhodamine, Multiphoton microscopy, Microscopy

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Proceedings Article | 24 April 2001 Paper

Chronic imaging of amyloid plaques in the live mouse brain using multiphoton microscopy

Brian Bacskai, Watt Webb, Stephen Kajdasz, Rebecca Williams, Warren Zipfel, R. Christie, Karl Kasischke, B. Hyman

Proceedings Volume 4262, (2001) https://doi.org/10.1117/12.424546

KEYWORDS: Brain, Neuroimaging, In vivo imaging, Multiphoton microscopy, Skull, Tissues, Proteins, Luminescence, Angiography, Blood vessels

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Showing 5 of 12 publications

Conference Committee Involvement (1)

Advanced Photon Counting Techniques

1 October 2006 | Boston, Massachusetts, United States

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