Brian Pogue is Professor of Engineering, Physics & Astronomy, and Surgery at Dartmouth College in Hanover, NH, where he is director of MS and PhD Programs at the Engineering School. He has a Ph.D. in Medical/Nuclear Physics from McMaster University, Canada, was a post-doctoral fellow at the Harvard Medical School, Massachusetts General Hospital. Joining the Dartmouth faculty since 1996, he has recently founded the Center for Imaging Medicine at Dartmouth, focusing on advancing optical imaging technologies in cancer diagnosis & management into clinical trial use. He has published over 300 peer-reviewed papers and 400 conference proceedings in imaging, surgery, medical oncology and radiotherapy. His NCI funded research program helps maintain the Optics in Medicine laboratory at Dartmouth, housing over two dozen faculty, staff and students. He is currently an editorial board member for Physics in Medicine & Biology, Medical Physics, the Journal of Biomedical Optics, and Breast Cancer Research. He has been elected a Fellow of the Optical Society of America (OSA) and the American Institute of Medical and Biological Engineering (AIMBE).
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HSF and CP imaging methods are both known to alter the reflectance image sensitivity to diffuse multiply- scattered and superficially backscattered photons. This results in enhanced contrast, compared to standard wide-field imaging, based on tissue surface microstructure and composition. Measurements in tissue-simulating optical phantoms show that CP images display contrast based on both scattering and absorption, while HSF is specifically sensitive to scatter-only contrast, strongly suppressing absorption-based contrast. By altering the frequency used, the degree of contrast suppression or enhancement can be tuned.1 This suggests that an inexpensive HSF imaging system could have potential to aid diagnostic procedures, where CP is the current state-of-the-art imaging modality.
Tumor implantation model for rapid testing of lymphatic dye uptake from paw to node in small animals
The goal of this work was to successfully deploy and test an intra-nodal cancer-cell injection model to enable planar fluorescence imaging of a clinically relevant blue dye, specifically methylene blue – used in the sentinel lymph node procedure – in normal and tumor-bearing animals, and subsequently segregate tumor-bearing from normal lymph nodes. This direct-injection based tumor model was employed in athymic rats (6 normal, 4 controls, 6 cancer-bearing), where luciferase-expressing breast cancer cells were injected into axillary lymph nodes. Tumor presence in nodes was confirmed by bioluminescence imaging before and after fluorescence imaging. Lymphatic uptake from the injection site (intradermal on forepaw) to lymph node was imaged at approximately 2 frames/minute. Large variability was observed within each cohort.
Quantifying receptor density in vivo using a dual probe approach with fluorescence molecular imaging
A dark-field scanning spectroscopy platform for localized scatter and fluorescence imaging of tissue
Receiver operating characteristic and location analysis of simulated near-infrared tomography images