Femtosecond (fs) ablation is mediated via electron avalanche and multiphoton ionization and is characterized by very
precise cutting and undetectable thermal damage in biological tissues. We have used a 775nm, 150 fs, 1kHz laser system
compared to two conventional bone cutting techniques using carbide and diamond tip burs in a mice calvarial wound
healing model. Wound healing was evaluated using micro computerized tomographs and histological techniques. Good
healing outcomes were found for fs laser surgery in comparison to the conventional surgical methods. However, the
degree of healing was highly variable in all treatment groups. The realization of healing comparable to that observed for
conventional surgical tools demonstrates the possible use of fs lasers for clinical surgery involving small bones where a
much higher degree of precision is required than that possible with current methods.