We develop a high speed compressive Raman imaging technology using a programmable binary spectral filter and a single channel detector to perform fast Raman detection and concentration estimation of know species over millimeters field of view. The technology is x100 times faster than commercial CCD based systems and x10 times faster than the EMCCD based systems. We report fast imaging of breast micro-calcifications, SERS particles, pharmaceutical tablets and micro-plastics. We also present a novel fast line scan compressive Raman imaging technique using spatial frequency-modulated illumination (SPIFI) that enables to encode space into the frequency domain to acquire single shot line images. We demonstrate the imaging and classification of three different chemical species at line scan rates of 40 Hz.
Conventional CARS microscopy requires scanning a point focus through the specimen limits imaging speed. We present a spatial frequency projection imaging (SPIFI) method for CARS microscopy to spatially multiplex CARS microscopy. A spinning disk modulator is used to rapidly modulate the Stokes field with a rapidly swept spatially periodic transmission grating. SPIFI-CARS images are obtained by Fourier transforming the single pixel signal. Images of CARS and second harmonic generation from histological slices will be presented. The physics of image formation and the impact of multiplexing on SNR will be discussed. Prospects for scaling to high speed CARS imaging will be discussed.