The infrared (IR) imaging missile’s dome will be heated when fly at high speed in the atmosphere because of the friction of the air flow blocking. The detector’s performance will be decline if the dome surface is heated to a certain temperature. In this paper, we find a right way to evaluate the aerothermal effects in the imaging and information processing algorithm. Which have three steps including the aerothermal radiation calculation, quantization and image reconstruction. Firstly, the aerothermal radiation is calculated by using a combination of both methods of theoretical analysis and experiment data. Secondly, the relationship between aerothermal radiation and IR images background mean gray and noise can be calculated through the analysis of the experiment data. At last, we can rebuild an aerodynamic heating effect of infrared images fusion with target and decoy, which can be used for virtual prototyping platform missile trajectory simulation. It can be found that the above constructed images have good agreements with the actual image according to comparison between the simulation data and experiment data. It is an economic method that can solve the lab aerodynamic heating simulation and modeling problems.