A technique for the fabrication of luminescence based fiber optic optrodes with multiple analyte sensitivity is proposed.
Combination of photosensitive polymers doped with different luminescent indicators was used to produce fiber probes,
by self-guiding photopolymerization, having different geometries and sensing capabilities. Results demonstrating the
method flexibility are shown with luminescent probes doped with CdSe/ZnS quantum dots and an organometalic
ruthenium complex for simultaneous detection of oxygen and temperature.
Recently the area of bioimaging has benefited from new types of image enhancing agents such as quantum dots, carbon
nanotubes and other nanoparticles. Cellular or even molecular level resolution has been achieved with different
techniques during these last years (i.a. Fluorescence microscopy, PET/CT scan, AFM). Optical Coherence Tomography
(OCT) as an imaging technique should also profit from newly developed probes. In this work we explored the tunable
properties of different types of nanoparticles as contrast enhancers in OCT applications. We mainly studied the
development and characteristics of metallic nanoparticles with tunable properties: gold nanoshells made of a silica core
coated with a gold shell. Nanoshell and nanoparticles processing techniques are discussed, as well as their optimization
for designing particles with specific absorption and scattering characteristics, and its use in OCT imaging.