Prof. Chan Kwon Jung Profile

Prof. Chan Kwon Jung

at The Catholic Univ. of Korea

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Proceedings Article | 12 March 2024 Presentation + Paper

High-resolution label-free ultraviolet photoacoustic microscopy via an ultraviolet-transparent ultrasound transducer

Donggyu Kim, Eunwoo Park, Jeongwoo Park, Bjarne Perleberg, Sora Jeon, Joongho Ahn, Mingyu Ha, Hyung Ham Kim, Jin Young Kim, Chan Kwon Jung, Chulhong Kim

Proceedings Volume 12842, 1284205 (2024) https://doi.org/10.1117/12.3000818

KEYWORDS: Histopathology, Ultrasound transducers, Photoacoustic microscopy, Photoacoustic imaging

Read Abstract +

Ultraviolet photoacoustic microscopy (UV-PAM) has emerged as a promising medical imaging technique for alternative histopathology, relying on the inherent optical absorption of DNA/RNA. However, traditional UV-PAM faces resolution challenges compared to clinical histological methods, limiting the observation of cellular structures. This limitation stems from the constraints of conventional reflection-mode UV-PAM systems, utilizing opto-ultrasound beam combiners or ring-shaped ultrasound transducers. These components impose constraints on numerical apertures (NA), thereby limiting spatial resolution. On the flip side, transmission-mode UV-PAM encounters difficulties in imaging thick specimens due to signal attenuation. In this study, we introduce an innovative solution – the development of an ultraviolet-transparent ultrasound transducer (UV-TUT) – overcoming these limitations and enabling high-resolution UV-PAM system. The UV-TUT significantly enhances both NA and lateral resolution, outperforming previous reflection-mode UV-PAM systems. With an impressive light transmission efficiency in the UV region and sensitivity four times greater than traditional ring-shaped ultrasound transducers, the UV-TUT lays the foundation for improved imaging capabilities. Leveraging the capabilities of the UV-TUT, we exploited a UV-PAM system, showcasing superior performance for imaging mouse brain tissue sections compared to conventional opto-ultrasound beam combiner-based UV-PAM. Furthermore, our application of photoacoustic histopathology on uterine cancer tissue sections demonstrated image quality comparable to microscopy images, providing valuable insights for accurate histopathological analysis. This work signifies a significant advancement in UV-PAM system, holding the promise to enhance the clinical utility of alternative histopathology with unprecedented resolution and imaging capabilities.

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