Dr. Changhui Li Profile

Dr. Changhui Li

Associate Professor at Peking Univ

SPIE Involvement:

Conference Program Committee | Author

Area of Expertise:

Biomedical optics , medical imaging , computational electromagnetics , photoacoustic tomography , molecular imaging

Profile Summary

Changhui Li is an assistant professor of the Department of Biomedical at Peking University. He received his BS and MS degree in Peking University at 1997 and 2000, respectively. He got his PhD in Physics at 2006 from the Department of Physics at Texas A&M University. Dr. Li's research focuses on biomedical optics, functional and molecular imaging, and computational electromagnetics.

Publications (23)

PROCEEDINGS ARTICLE | March 15, 2018

Developing a real-time photoacoustic-ultrasound dual modality functional imaging system (Conference Presentation)

Proc. SPIE. 10494, Photons Plus Ultrasound: Imaging and Sensing 2018

KEYWORDS: Optical parametric oscillators, Multimodal imaging, Imaging systems, Ultrasonography, Transducers, Functional imaging, Photoacoustic imaging, Photoacoustic spectroscopy, 3D scanning, Signal detection

PROCEEDINGS ARTICLE | March 14, 2018

Photoacoustic/ultrasound dual imaging of human superficial lesions: an initial clinical study (Conference Presentation)

Proc. SPIE. 10487, Multimodal Biomedical Imaging XIII

KEYWORDS: Breast, Image fusion, Laser sources, Tumors, Doppler effect, Imaging systems, Ultrasonography, Oxygen, Photoacoustic imaging, In vivo imaging

Objective: To develop dual-modality Photoacoustic(PA)/Ultrasound(US) system based on clinical US machine and performed imaging study of in vivo human superficial lesions. Methods: A dual-modality PA/US system was developed based on a high-end clinical US machine with a handheld probe for US/PA dual modality imaging, equipped with multi-wavelength laser source. Twenty-three patients were enrolled consecutively from the outpatients and inpatients of Peking Union Medical College Hospital (PUMCH) from Dec. 15th 2016 to Apr.15th 2017. All the patients underwent ultrasound examinations including both gray scale and color Doppler flow imaging ultrasound (CDFI) to evaluate the morphological and vascular information of the lesions. PA/US imaging was performed right after CDFI, the CDFI and the PA/US dual imaging information of each case were compared. Results: The laser source for PAI generates multi-wavelength laser pulses at 10Hz. Therefore, deoxyhemoglobin and hematoglobulin in tumor vasculature, which serve as different optical absorbers at specific wavelengths, can be evaluated and compared through PAI. PA/US dual modality imaging was performed in 23 cases, including 10 thyroid lesions, 10 breast lesions, and 3 soft tissue endometriosis lesions. All of the lesions performed surgery with pathology confirmed diagnosis. Our PA/US dual modality imaging system showed high quality gray scale ultrasonic and dual-modality fusion images. According to the results, significant differences exist between PAI and CDFI. PAI could reveal some blood vessels that were not sensitive for Doppler ultrasound. PAI proved the ability of imaging both the peripheral and intra-nodular vessels of human superficial lesions, as well as detecting the difference of oxygen saturation between benign and malignant tumor. Conclusion: Our study demonstrated that photoacoustic imaging could provide important complementary information for traditional ultrasound in superficial lesion examination, which has a great potential for clinical diagnosis.

PROCEEDINGS ARTICLE | March 3, 2017

Polarization-dependent optical reflection ultrasonic detection

Proc. SPIE. 10064, Photons Plus Ultrasound: Imaging and Sensing 2017

KEYWORDS: Refractive index, Prisms, Polarization, Reflection, Sensors, Interfaces, Ultrasonics, Transducers, Photoacoustic tomography, Acoustics, Laser beam diagnostics

SPIE Journal Paper | May 12, 2016

Noninvasively measuring oxygen saturation of human finger-joint vessels by multi-transducer functional photoacoustic tomography

Deng, Zijian , Li, Changhui

JBO Vol. 21 Issue 06

KEYWORDS: Transducers, Acquisition tracking and pointing, Oxygen, Photoacoustic tomography, Lithium, Blood vessels, Signal detection, Image resolution, Ultrasonics, Imaging systems

PROCEEDINGS ARTICLE | September 17, 2014

Dual-modal whole eye photoacoustic imaging

Proc. SPIE. 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)

KEYWORDS: Signal to noise ratio, Image fusion, Eye, Tissues, Imaging systems, Ultrasonography, Retina, Iris, Photoacoustic imaging, In vivo imaging

PROCEEDINGS ARTICLE | September 17, 2014

Developing a free-space fluorescence molecular tomography system

Proc. SPIE. 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)

KEYWORDS: Optical fibers, Optical filters, Imaging systems, Quartz, Luminescence, Lamps, Tomography, Data acquisition, Molecular imaging, Fluorescence tomography

SPIE Journal Paper | July 28, 2014

Viscous optical clearing agent for in vivo optical imaging

Deng, Zijian , Jing, Lijia , Wu, Ning , lv, Pengyu , Jiang, Xiaoyun , Ren, Qiushi , Li, Changhui

JBO Vol. 19 Issue 07

KEYWORDS: Skin, Optical clearing, Optical imaging, In vivo imaging, Optical coherence tomography, Imaging systems, Tissue optics, Ultrasonics, Photoacoustic microscopy, Ultrasonography

SPIE Journal Paper | May 9, 2014

Fast spatiotemporal image reconstruction based on low-rank matrix estimation for dynamic photoacoustic computed tomography

Wang, Kun , Xia, Jun , Li, Changhui , Wang, Lihong , Anastasio, Mark

JBO Vol. 19 Issue 05

KEYWORDS: Photoacoustic tomography, Image restoration, Reconstruction algorithms, Principal component analysis, Image filtering, Transducers, Biological research, Imaging systems, Video, Linear filtering

PROCEEDINGS ARTICLE | March 3, 2014

Low-rank matrix estimation-based spatio-temporal image reconstruction for dynamic photoacoustic computed tomography

Proc. SPIE. 8943, Photons Plus Ultrasound: Imaging and Sensing 2014

KEYWORDS: CT reconstruction, Imaging systems, Image restoration, Image analysis, Tomography, Data acquisition, Transducers, Photoacoustic tomography, Reconstruction algorithms, Algorithm development

SPIE Journal Paper | July 9, 2013

Acoustically penetrable optical reflector for photoacoustic tomography

Deng, Zijian , Zhao, Honghong , Ren, Qiushi , Li, Changhui

JBO Vol. 18 Issue 07

KEYWORDS: Acquisition tracking and pointing, Ultrasonography, Transducers, Signal detection, Photoacoustic tomography, Reflectors, Ultrasonics, Acoustics, Imaging systems, Reflection

PROCEEDINGS ARTICLE | March 4, 2013

Developing photoacoustic ocular imaging system

Proc. SPIE. 8581, Photons Plus Ultrasound: Imaging and Sensing 2013

KEYWORDS: Eye, Tissues, Imaging systems, Ultrasonography, Retina, Iris, Photoacoustic tomography, Photoacoustic spectroscopy, Tissue optics, Absorption

PROCEEDINGS ARTICLE | February 23, 2012

In vivo imaging of small animal models by photoacoustic microscopy

Proc. SPIE. 8223, Photons Plus Ultrasound: Imaging and Sensing 2012

KEYWORDS: Optical microscopes, Biomedical optics, Tissues, Imaging systems, Image resolution, Photoacoustic microscopy, In vivo imaging, Tissue optics, Absorption, Animal model studies

PROCEEDINGS ARTICLE | February 18, 2011

Photoacoustic tomography of water in biological tissue

Proc. SPIE. 7899, Photons Plus Ultrasound: Imaging and Sensing 2011

KEYWORDS: Near infrared, Tissues, Imaging systems, Photoacoustic tomography, Acquisition tracking and pointing, Photoacoustic spectroscopy, In vivo imaging, Tissue optics, Absorption, Brain

SPIE Journal Paper | May 1, 2010

Photoacoustic tomography of water in phantoms and tissue

Xu, Zhun , Li, Changhui , Wang, Lihong

JBO Vol. 15 Issue 03

KEYWORDS: Absorption, Tissue optics, Acquisition tracking and pointing, Bioalcohols, Photoacoustic tomography, Tissues, Signal detection, Transducers, Lithium, Laser tissue interaction

SPIE Journal Paper | March 1, 2010

Compressed sensing in photoacoustic tomography in vivo

Guo, Zijian , Li, Changhui , Song, Liang , Wang, Lihong

JBO Vol. 15 Issue 02

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, In vivo imaging, Data acquisition, Compressed sensing, Sensors, Reconstruction algorithms, Ultrasonics, Tomography, Wavelets

PROCEEDINGS ARTICLE | February 24, 2010

Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography

Proc. SPIE. 7564, Photons Plus Ultrasound: Imaging and Sensing 2010

KEYWORDS: Real time imaging, Imaging systems, Image resolution, Photoacoustic tomography, Hemodynamics, Acquisition tracking and pointing, Photoacoustic spectroscopy, In vivo imaging, Absorption, Brain

PROCEEDINGS ARTICLE | February 11, 2010

Compressed sensing in photoacoustic tomography with in vivo experiments

Proc. SPIE. 7564, Photons Plus Ultrasound: Imaging and Sensing 2010

KEYWORDS: CT reconstruction, Sensors, Ultrasonics, Tomography, Data acquisition, Photoacoustic tomography, Acquisition tracking and pointing, Reconstruction algorithms, In vivo imaging, Compressed sensing

SPIE Journal Paper | January 1, 2010

Real-time photoacoustic tomography of cortical hemodynamics in small animals

Li, Changhui , Aguirre, Andres , Gamelin, John , Maurudis, Anastasios , Zhu, Quing , Wang, Lihong

JBO Vol. 15 Issue 01

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, Hemodynamics, Ultrasonography, Absorption, In vivo imaging, Photoacoustic spectroscopy, Brain, Imaging systems, Pulsed laser operation

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SPIE Journal Paper | March 1, 2009

Photoacoustic tomography of the mouse cerebral cortex with a high-numerical-aperture-based virtual point detector

Li, Changhui , Wang, Lihong

JBO Vol. 14 Issue 02

KEYWORDS: Sensors, Transducers, Acquisition tracking and pointing, Ultrasonics, Photoacoustic tomography, Cerebral cortex, Image resolution, Signal detection, Signal to noise ratio, Ferroelectric polymers

PROCEEDINGS ARTICLE | February 25, 2009

Novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography using carbon nanotubes (CNTs) as a dual contrast agent

Proc. SPIE. 7177, Photons Plus Ultrasound: Imaging and Sensing 2009

KEYWORDS: Breast, Breast cancer, Tissues, Ultrasonography, Scanners, Transducers, Antennas, Acquisition tracking and pointing, Microwave radiation, Single walled carbon nanotubes

PROCEEDINGS ARTICLE | February 25, 2009

High-NA-based virtual point detectors for photoacoustic imaging

Proc. SPIE. 7177, Photons Plus Ultrasound: Imaging and Sensing 2009

KEYWORDS: Sensors, Ultrasonography, Ultrasonics, Tomography, Image sensors, Transducers, Photoacoustic tomography, Acquisition tracking and pointing, Signal detection, Ferroelectric polymers

PROCEEDINGS ARTICLE | February 28, 2008

Improving the image quality of photoacoustic tomography (PAT) by using a negative acoustic lens

Proc. SPIE. 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics

KEYWORDS: Signal to noise ratio, Ultrasonography, Image quality, Transducers, Photoacoustic tomography, Acquisition tracking and pointing, Reconstruction algorithms, Signal generators, Acoustics, Signal detection

PROCEEDINGS ARTICLE | February 28, 2008

RF diffraction effect in RF-induced thermoacoustic tomography: calibration and distortion

Proc. SPIE. 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics

KEYWORDS: Diffraction, Tissues, Calibration, Dielectrics, Numerical simulations, Distortion, Tomography, Transducers, Acoustics, Signal detection

Showing 5 of 23 publications

Conference Committee Involvement (4)

Photons Plus Ultrasound: Imaging and Sensing 2019

2 February 2019 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2018

28 January 2018 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2017

29 January 2017 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2016

14 February 2016 | San Francisco, California, United States

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