Multi-modality image registration plays an important role in the domain of medical image processing. Diffeomorphic demons method has been proven to be a robust and efficient way for single mode image registration. However, it cannot deal with multi-modality image. In this paper we introduce mutual information into diffeomorphic demons method. On the basis of original force for driving image deformation, the proposed method adds mutual information gradient on the current transformation and adds mutual information into the energy function. We compare the performance of image registration results among our proposed method, diffeomorphic demons method and B-spline based free form deformation method in combination with mutual information. Experiment shows that our proposed method gives the better results like the smallest registration errors in case of local distortions. In conclusion, our proposed method has good performance in dealing with local deformation multi-model image registration.