Porphyrins bearing sugars and other motifs are proposed for a variety of therapeutic applications. Non-hydrolysable
glyco conjugates of porphyrins can be formed in rapid, room temperature reacting in greater than 90% yields from
tetraperfluorophenyporphyrin. Additional functional groups can be appended using the same chemistry but different
stoichiometries of the reagents. Thus sugars, amines, peptides, and cationic moieties designed to target cancer cells or
other diseased or disease-causing cells are made rapidly and cleanly. These compounds can then be rapidly screened for
cell uptake, or selected from combinatorial libraries by cell uptake assays using a combination of fluorescence
microscopy and mass spectrometry. Modifications of the macrocycle allow fine-tuning of the photonic properties for
specific medical, imaging, or biochemical applications.