Dr. Charles Maphanga
Doctoral Candidate at CSIR National Laser Ctr.
SPIE Involvement:
Author
Area of Expertise:
Human Immunideficiecy Virus (HIV) , Femtosecond laser , Optical drug translocation , Microfluidics , Optical trapping and sorting , Point-of-Care (POC) diagnostic devices
Websites:
Profile Summary

My masters research topic primarily focused on the use of laser technology as an alternative technique for administering drugs (medicines) into the human body in a targeted manner other than using the conventional enteral and parenteral routes of drug administration. I used a pulsed femtosecond laser with high peak power and ultra-short pulses to create a sub-microscopic pore on the cell membrane of HIV-l infected cells (in-vitro) in the presence of antiretroviral (ARV) drugs, and further performed cell viability, cytotoxicity, and HIV-1 infection levels post laser-enhanced drug delivery using molecular biology assays. Currently I am still in the early stages of my PhD degree. In this new exciting adventure I am using microfluidics approach integrated to a laser device in order to design and fabricate a laser-based Point-of-Care (POC) device for real-time HIV qualitative and quantitative testing. This device will be very beneficial especially in resource-limited settings and developing countries.
Publications (11)

Proceedings Article | 5 March 2021 Presentation + Paper
Proc. SPIE. 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics
KEYWORDS: Gold, Surface plasmons, Proteins, Biosensing, Diagnostics, Biosensors, Scanning electron microscopy, Biological research, UV-Vis spectroscopy, Signal detection

Proceedings Article | 5 March 2021 Poster + Presentation + Paper
Proc. SPIE. 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics
KEYWORDS: Gold, Surface plasmons, Biosensing, Nanoparticles, Dielectrics, Diagnostics, Biosensors, Transmission electron microscopy, Adsorption, Biological research

Proceedings Article | 5 March 2021 Presentation + Paper
Proc. SPIE. 11661, Plasmonics in Biology and Medicine XVIII
KEYWORDS: Refractive index, Surface plasmons, Sensors, Polymers, Resistance, Biosensors, Optical testing, Molecular interactions

Proceedings Article | 21 February 2020 Presentation + Paper
Proc. SPIE. 11257, Plasmonics in Biology and Medicine XVII
KEYWORDS: Gold, Plasmonics, Point-of-care devices, Sensors, Nanoparticles, Glasses, Biosensors, CCD cameras, Ocean optics, Transmittance

Proceedings Article | 20 February 2020 Paper
Proc. SPIE. 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020
KEYWORDS: Gold, Thin films, Biosensing, Sensors, Nanoparticles, Glasses, Molecules, Surface enhanced Raman spectroscopy, Raman spectroscopy, Raman scattering

Showing 5 of 11 publications
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