Charles Maphanga
Doctoral Candidate at Council for Scientific and Industrial Research
SPIE Involvement:
Author | Student Chapter President
Area of Expertise:
Human Immunideficiecy Virus (HIV) , Femtosecond laser , Optical drug translocation , Microfluidics , Optical trapping and sorting , Point-of-Care (POC) diagnostic devices
Websites:
Profile Summary

My masters research topic primarily focused on the use of laser technology as an alternative technique for administering drugs (medicines) into the human body in a targeted manner other than using the conventional enteral and parenteral routes of drug administration. I used a pulsed femtosecond laser with high peak power and ultra-short pulses to create a sub-microscopic pore on the cell membrane of HIV-l infected cells (in-vitro) in the presence of antiretroviral (ARV) drugs, and further performed cell viability, cytotoxicity, and HIV-1 infection levels post laser-enhanced drug delivery using molecular biology assays. Currently I am still in the early stages of my PhD degree. In this new exciting adventure I am using microfluidics approach integrated to a laser device in order to design and fabricate a laser-based Point-of-Care (POC) device for real-time HIV qualitative and quantitative testing. This device will be very beneficial especially in resource-limited settings and developing countries.
Publications (5)

Proceedings Article | 1 March 2019
Proc. SPIE. 10876, Optical Interactions with Tissue and Cells XXX
KEYWORDS: Microorganisms, Acquisition tracking and pointing, Bacteria, Near infrared, Femtosecond phenomena, Laser irradiation, Ultraviolet radiation, Microscopes, Pulsed laser operation, Viruses

Proceedings Article | 15 February 2017
Proc. SPIE. 10062, Optical Interactions with Tissue and Cells XXVIII
KEYWORDS: In vitro testing, Femtosecond phenomena, Gaussian beams, Statistical analysis, Cancer, In vivo imaging, Titanium, Sapphire lasers, Beam controllers, Control systems, Virtual colonoscopy, Objectives, Mirrors, Laser therapeutics

Proceedings Article | 15 February 2017
Proc. SPIE. 10062, Optical Interactions with Tissue and Cells XXVIII
KEYWORDS: Plasma, Femtosecond phenomena, Ultrafast phenomena, Electrons, Pulsed laser operation, Ovary, Genetics, Titanium, Sapphire, Optical amplifiers, Objectives, Microscopes, Camera shutters, Mirrors

Proceedings Article | 8 February 2017
Proc. SPIE. 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
KEYWORDS: Photodynamic therapy, Gold, Nanoparticles, Melanoma, Cancer, Oxygen, Cell death, Acquisition tracking and pointing

Proceedings Article | 8 February 2017
Proc. SPIE. 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
KEYWORDS: Nanoparticles, Cancer, Photodynamic therapy, Melanoma, Gold, Silver, Cell death, Picosecond phenomena

SIGN IN TO:
  • View contact details

UPDATE YOUR PROFILE
Is this your profile? Update it now.
Don’t have a profile and want one?

Advertisement
Advertisement
Back to Top