Charles Maphanga
Doctoral Candidate at Council for Scientific and Industrial Research
SPIE Involvement:
Author | Student Chapter President
Area of Expertise:
Human Immunideficiecy Virus (HIV) , Femtosecond laser , Optical drug translocation , Microfluidics , Optical trapping and sorting , Point-of-Care (POC) diagnostic devices
Websites:
Profile Summary

My masters research topic primarily focused on the use of laser technology as an alternative technique for administering drugs (medicines) into the human body in a targeted manner other than using the conventional enteral and parenteral routes of drug administration. I used a pulsed femtosecond laser with high peak power and ultra-short pulses to create a sub-microscopic pore on the cell membrane of HIV-l infected cells (in-vitro) in the presence of antiretroviral (ARV) drugs, and further performed cell viability, cytotoxicity, and HIV-1 infection levels post laser-enhanced drug delivery using molecular biology assays. Currently I am still in the early stages of my PhD degree. In this new exciting adventure I am using microfluidics approach integrated to a laser device in order to design and fabricate a laser-based Point-of-Care (POC) device for real-time HIV qualitative and quantitative testing. This device will be very beneficial especially in resource-limited settings and developing countries.
Publications (4)

PROCEEDINGS ARTICLE | February 15, 2017
Proc. SPIE. 10062, Optical Interactions with Tissue and Cells XXVIII
KEYWORDS: Mirrors, Titanium, Femtosecond phenomena, Gaussian beams, Laser therapeutics, Statistical analysis, Cancer, Control systems, Objectives, Sapphire lasers, In vivo imaging, In vitro testing, Beam controllers, Virtual colonoscopy

PROCEEDINGS ARTICLE | February 15, 2017
Proc. SPIE. 10062, Optical Interactions with Tissue and Cells XXVIII
KEYWORDS: Ultrafast phenomena, Microscopes, Mirrors, Titanium, Optical amplifiers, Femtosecond phenomena, Electrons, Sapphire, Objectives, Genetics, Pulsed laser operation, Camera shutters, Ovary, Plasma

PROCEEDINGS ARTICLE | February 8, 2017
Proc. SPIE. 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
KEYWORDS: Gold, Photodynamic therapy, Cancer, Nanoparticles, Silver, Melanoma, Cell death, Picosecond phenomena

PROCEEDINGS ARTICLE | February 8, 2017
Proc. SPIE. 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI
KEYWORDS: Gold, Photodynamic therapy, Cancer, Nanoparticles, Oxygen, Melanoma, Cell death, Acquisition tracking and pointing

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