Design rules and the design rule check (DRC) utility are conventional approaches to design for manufacturability
(DFM). The DRC utility is based on unsophisticated rules to check the design layout in a simple environment. As the
design dimension shrinks drastically, the introduction of a more powerful DFM utility with model-based layout
patterning check (LPC) becomes mandatory for designers to filter process weak-points before taping out layouts. In this
paper, a system of integrated hotspot scores consisting of three lithography sensitive indexes is proposed to assist
designers to circumvent risky layout patterns in lithography. With the hotspot fixing guideline and the hotspot severity
classification deduced from the scoring system provided in this paper, designers can deliver much more manufacturable
designs.
Tissue engineering is emerging as a promising method for repairing damaged tissues. Due to cartilage's common wear
and injury, in vitro production of cartilage replacements have been an active area of research. Finding the optimal
condition for the generation of the collagen matrix is crucial in reproducing cartilages that closely match those found in
human. Using multiphoton autofluorescence and second-harmonic generation (SHG) microscopy we monitored the
effect of mechanical stress on mesenchymal stem cell collagen production. Bone marrow mesenchymal stem cells in the
form of pellets were cultured and periodically placed under different mechanical stress by centrifugation over a period of
four weeks. The differently stressed samples were imaged several times during the four week period, and the collagen
production under different mechanical stress is characterized.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.