Prof. Christine P. Hendon Profile

Prof. Christine P. Hendon

at Columbia University

SPIE Involvement:

Conference Program Committee | Editor-in-Chief: Biophotonics Discovery | Author | Student Chapter Advisor

Area of Expertise:

optical coherence tomography , image and signal processing , cardiac imaging , near infrared spectroscopy

Websites:

Company Website

Publications (62)

Proceedings Article | 2 April 2024 Presentation + Paper

Label refinement for noisy annotation in weakly supervised segmentation

Ziyi Huang, Andrew Laine, Elsa Angelini, Christine Hendon, Haofeng Zhang, Fuyong Xing, Yu Gan, Hongshan Liu

Proceedings Volume 12926, 129260W (2024) https://doi.org/10.1117/12.3006817

KEYWORDS: Image segmentation, Neural networks, Optical coherence tomography, Medical imaging, Deep learning

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Proceedings Article | 13 March 2024 Presentation

Catheter-based diffuse reflectance spectroscopy for cardiac substrate mapping

Jonah Majumder, Haiqiu Yang, Ziyi Huang, Kenneth Laurita, Andrew Rollins, Deepak Saluja, Christine Hendon, Aidan Therien

Proceedings Volume PC12836, PC128360B (2024) https://doi.org/10.1117/12.3001935

KEYWORDS: Diffuse reflectance spectroscopy, Tissues, Radiofrequency ablation, Atrial fibrillation, Ablation, Tissue optics, Reflectivity, Photons, Biological samples, Spectroscopy

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Proceedings Article | 13 March 2024 Presentation

High density optical substrate mapping of the left atrium with near infrared spectroscopy

Ziyi Huang, Christine Hendon, Haiqiu Yang, Jonah Majumder, Kenneth Laurita, Andrew Rollins

Proceedings Volume 12819, 128190S (2024) https://doi.org/10.1117/12.3002814

KEYWORDS: Near infrared spectroscopy, Tissue optics, Spectral density, Blood, Absorbance, Radio optics, Atrial fibrillation, Visualization, Tissues, Radiofrequency ablation

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Proceedings Article | 13 March 2024 Presentation

Compressed sensing on displacement signals measured with optical coherence tomography

Brian Frost, Nikola Janjušević, C. Elliott Strimbu, Christine Hendon

Proceedings Volume PC12830, PC128302Q (2024) https://doi.org/10.1117/12.3005009

KEYWORDS: Optical coherence tomography, Compressed sensing, Motion measurement, In vivo imaging, Vibrometry, Mechanics, Cochlea, Vibration, Tissues, Tissue optics

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Proceedings Article | 13 March 2024 Presentation + Paper

PSOCT, NIRS, and optical mapping of low voltage zones in atrial fibrillation

Lydia Akino, Michael Douglass, Andrew Rollins, Juan Perez, Haiqiu Yang, Jonah Majumder, Walter Hoyt, Ohad Ziv, Kenneth Laurita, Christine Hendon

Proceedings Volume 12819, 128190R (2024) https://doi.org/10.1117/12.3001724

KEYWORDS: Atrial fibrillation, Near infrared spectroscopy, Tissues, Ablation, In vivo imaging, Tissue optics, Heart, Birefringence, Veins, Pathology

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Atrial fibrillation (AF) is the most common arrhythmia worldwide. An increasingly common treatment option is catheter ablation. During this procedure, the clinician steers a catheter into the left atrium and ablates a lesion fence around the pulmonary veins, a common source of ectopic signals. This lesion fence blocks arrhythmogenic tissue from initiating an erroneous heartbeat. However, if the disease has progressed from paroxysmal to persistent, pathogenic tissue exists throughout the atrium, and common ablation schemes are not as effective. In this case, technologies exist to electroanatomically map the atrium and guide clinicians in targeting adjunctive AF ablation targets. Low voltages mapped in vivo are a well-documented way of identifying atrial fibrosis, an important substrate for AF. Ablating low voltage zones in patients with a more developed disease can help terminate AF and improve long-term outcomes, but low voltage measurements are not specific to fibrosis. Treatment results vary because the targeting that electroanatomical mapping provides is incomplete. Our group has shown that polarization-sensitive optical coherence tomography (PSOCT) and near infrared spectroscopy (NIRS) can monitor lesion formation in vivo and differentiate tissue types in the atrium. Now, we are investigating the technology’s utility in identifying AF targets prior to ablation. We have collaborated in developing a swine model of AF that shows the atria remodels during the diseased state. Because of this, we can electroanatomically map these diseased hearts in vivo to measure low voltage zones. Subsequently, we examine the left atrium ex vivo using benchtop PSOCT, NIRS, and optical mapping (OM) and register these optical measurements to the in vivo low voltage zones. We show that OM confirms abnormal conduction, while PSOCT- and NIRS-derived metrics have promise for identifying low voltage zones. We confirm these measures with histological identification of fibrosis. This suggests the feasibility of using PSOCT-NIRS at the catheter tip to detect AF ablation targets.

Proceedings Article | 13 March 2024 Paper

A multimodal PSOCT-NIRS catheter for ablation of atrial fibrillation

Michael Douglass, Reza Mohammadpour, Gauri Srikumar, Alice Qian, Juan Perez, Jonah Majumder, Christine Hendon, Kenneth Laurita, Walter Hoyt, Ohad Ziv, Andrew Rollins

Proceedings Volume 12834, 1283407 (2024) https://doi.org/10.1117/12.3006074

KEYWORDS: Ablation, Near infrared spectroscopy, Atrial fibrillation, Tissues, Optical coherence tomography, Heart, Radiofrequency ablation, Polarization, In vivo imaging, Birefringence

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SPIE Journal Paper | 28 February 2024 Open Access

Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy

Haiqiu Yang, Jonah Majumder, Ziyi Huang, Deepak Saluja, Kenneth Laurita, Andrew Rollins, Christine Hendon

JBO, Vol. 29, Issue 02, 028001, (February 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.2.028001

KEYWORDS: Tissues, Blood, Near infrared spectroscopy, Tissue optics, Radiofrequency ablation, Heart, Ablation, Data modeling, Education and training, Reflectivity

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Proceedings Article | 17 March 2023 Presentation

Multi-modal imaging system with optically integrated probe for left atrial anatomical mapping

Haiqiu Yang, Michael Douglass, Deepak Saluja, Kenneth Laurita, Andrew Rollins, Christine Hendon

Proceedings Volume PC12355, PC1235507 (2023) https://doi.org/10.1117/12.2650336

KEYWORDS: System integration, Radiofrequency ablation, Multimodal imaging, Integrated optics, Imaging systems, Tissues, Radio optics, Optical coherence tomography, Near infrared spectroscopy, Blood

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Proceedings Article | 15 March 2023 Presentation

Full-thickness fiber orientation mapping of the human uterus (Conference Presentation)

Jingpeng Hu, Christine Hendon, Kristin Myers, Aidan Therien

Proceedings Volume PC12385, PC123850B (2023) https://doi.org/10.1117/12.2649263

KEYWORDS: Uterus, Associative arrays, Tissues, Structured optical fibers, Optical coherence tomography, Analytical research, Multilayers, Mechanics

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Proceedings Article | 14 March 2023 Presentation + Paper

Polarization-Sensitive Optical Coherence Tomography (PSOCT) for identifying and analyzing gaps in lesion lines during ex vivo simulated radiofrequency ablation procedure

Michael Douglass, Lydia Akino, Juan Perez, Haiqiu Yang, Walter Hoyt, Ohad Ziv, Kenneth Laurita, Christine Hendon, Andrew Rollins

Proceedings Volume 12355, 1235503 (2023) https://doi.org/10.1117/12.2650838

KEYWORDS: Ablation, Tissues, Atrial fibrillation, Radiofrequency ablation, Polarization, Birefringence, Optical coherence tomography

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Proceedings Article | 9 March 2023 Presentation

Overall performance of compressed sensing of human breast OCT data using a predictive coding algorithm

Diego Song Cho, Christine Hendon

Proceedings Volume PC12367, PC123670S (2023) https://doi.org/10.1117/12.2652987

KEYWORDS: Reconstruction algorithms, Optical coherence tomography, Breast, Compressed sensing, Tissues, Denoising, Solids, Pathology, Image resolution, Error analysis

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Proceedings Article | 6 March 2023 Presentation

Optical coherence tomography enabled tissue architecture characterization of uterine tumors

Arielle Joasil, Haiqiu Yang, Hanina Hibshoosh, Christine Hendon

Proceedings Volume PC12368, PC1236809 (2023) https://doi.org/10.1117/12.2650591

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Tissue optics, Uterus, Surgery, Collagen, Analytical research

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Proceedings Article | 6 March 2023 Presentation

Optical coherence tomography texture analysis and classification of breast biopsies

Christine Hendon, Margherita Firenze, Yunhe Liu, Diana Mojahed, Nisha Gandhi, Hanina Hibshoosh, Richard Ha

Proceedings Volume PC12368, PC123680H (2023) https://doi.org/10.1117/12.2652988

KEYWORDS: Biopsy, Breast, Biological research, Coherence (optics), Image classification, Binary data, Optical coherence tomography, Machine learning, Image resolution, Feature extraction

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SPIE Journal Paper | 1 September 2022 Open Access

Optical coherence tomography holds promise to transform the diagnostic anatomic pathology gross evaluation process

Diana Mojahed, Matthew Applegate, Hua Guo, Bret Taback, Richard Ha, Hanina Hibshoosh, Christine Hendon

JBO, Vol. 27, Issue 09, 096003, (September 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.9.096003

KEYWORDS: Optical coherence tomography, Tissues, Pathology, Breast, Diagnostics, Tissue optics, Pancreas, Lung, Image resolution, Imaging systems

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Proceedings Article | 9 March 2022 Presentation

Deep learning to identify breast disease in an 87-patient clinical study of breast core biopsies to provide rapid biopsy evaluation

Nisha Gandhi, Margherita Firenze, Diana Mojahed, Christine Hendon, Hanina Hibshoosh, Hua Guo, Richard Ha

Proceedings Volume PC11949, PC119490G (2022) https://doi.org/10.1117/12.2610196

KEYWORDS: Biopsy, Breast, Optical coherence tomography, Biological research, Algorithm development, Image classification, Diagnostics, 3D image processing

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Proceedings Article | 7 March 2022 Presentation

Cardiac tissue substrate mapping with polarization-sensitive optical coherence tomography

Xiaowei Zhao, Ohad Ziv, Michael Douglass, Walter Hoyt, Michael Jenkins, Christopher Snyder, Christine Hendon, Kenneth Laurita, Andrew Rollins

Proceedings Volume PC11936, PC1193606 (2022) https://doi.org/10.1117/12.2607820

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Proceedings Article | 7 March 2022 Presentation

Real-time histology evaluation by optical coherence tomography (OCT) holds promise to improve the diagnostic anatomic pathology gross evaluation process

Diana Mojahed, Matthew Applegate, Hua Guo, Richard Ha, Hanina Hibshoosh, Christine Hendon

Proceedings Volume PC11948, PC119480Q (2022) https://doi.org/10.1117/12.2608908

KEYWORDS: Pathology, Optical coherence tomography, Diagnostics, Breast, Tissues, Prostate, Pancreas, Lung, Imaging systems, Image resolution

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Proceedings Article | 7 March 2022 Presentation

Compressed sensing of human breast optical coherence 3-D image volume data using predictive coding

Christine Hendon, Diego Song

Proceedings Volume PC11948, PC119480Z (2022) https://doi.org/10.1117/12.2605934

KEYWORDS: Breast, Image compression, Compressed sensing, Tissues, Reconstruction algorithms, Optical coherence tomography, Coherence (optics), 3D image processing, Denoising, Time metrology

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Proceedings Article | 7 March 2022 Poster + Presentation

Characterizing 3D and 2D fiber orientation architecture within OCT image sets of the human left atrium

Tirthraj Patel, Yiyi Chen, Christine Hendon

Proceedings Volume PC11936, PC119360I (2022) https://doi.org/10.1117/12.2610096

KEYWORDS: Optical coherence tomography, 3D image processing, Heart, Atrial fibrillation, Imaging systems, Tissue optics, Image processing, Image filtering, Image enhancement, Image contrast enhancement

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Proceedings Article | 7 March 2022 Presentation

Lesion gap assessment in left atrium by spectroscopic anatomical mapping with optically integrated catheter

Haiqiu Yang, Soo Young Park, Christine Hendon

Proceedings Volume PC11936, PC1193605 (2022) https://doi.org/10.1117/12.2608293

KEYWORDS: Near infrared spectroscopy, Spectroscopy, Integrated optics, Radiofrequency ablation, Radio optics, Heart, Atrial fibrillation, Veins, Tissue optics, Reflectivity

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Proceedings Article | 7 March 2022 Presentation

Cardiac endocardial left atrial substrate mapping and lesion depth assessment using near-infrared spectroscopy

Christine Hendon, Soo Young Park, Haiqiu Yang, Charles Marboe, Ohad Ziv, Kenneth Laurita, Andrew Rollins, Deepak Saluja

Proceedings Volume PC11936, PC1193609 (2022) https://doi.org/10.1117/12.2610367

KEYWORDS: Near infrared spectroscopy, Veins, Associative arrays, Tissue optics, Tissues, Systems modeling, Spectroscopy, Natural surfaces, Heart, Diffuse reflectance spectroscopy

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Proceedings Article | 5 March 2021 Presentation

Irrigated cardiac endocardial lesion assessment using single fiber-multispectral spectroscopy and neural networks

Soo Young Park, Haiqiu Yang, Rajinder Singh-Moon, Amardeep Saluja, Christine Hendon

Proceedings Volume 11621, 1162103 (2021) https://doi.org/10.1117/12.2578506

KEYWORDS: Neural networks, Spectroscopy, Radiofrequency ablation, Tissue optics, Optical spectroscopy, Tissues, Thermography, Temperature metrology, Light sources, In vivo imaging

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Proceedings Article | 5 March 2021 Presentation

Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography

James McLean, Isaac Donis, Christine Hendon

Proceedings Volume 11649, 1164913 (2021) https://doi.org/10.1117/12.2577426

KEYWORDS: Optical coherence tomography, 3D image processing, Visualization, Tissues, 3D modeling, Uterus, Image registration, Image enhancement, Collagen, 3D acquisition

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Proceedings Article | 5 March 2021 Presentation

Generalizable convolutional neural network (CNN) classification of breast cancer using images from two optical coherence tomography (OCT) systems

Diana Mojahed, Rohan Bareja, Theresa Lye, Richard Ha, Hanina Hibshoosh, Christine Hendon

Proceedings Volume 11631, 116310J (2021) https://doi.org/10.1117/12.2577422

KEYWORDS: Optical coherence tomography, Image resolution, Image classification, Convolutional neural networks, Classification systems, Tissues, Breast cancer, Tissue optics, Data acquisition, Breast

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Proceedings Article | 5 March 2021 Presentation

Spectroscopic anatomical mapping of left atrium endocardial substrate and lesion using an optically integrated mapping catheter

Soo Young Park, Rajinder Singh-Moon, Haiqiu Yang, Amardeep Saluja, Christine Hendon

Proceedings Volume 11621, 1162104 (2021) https://doi.org/10.1117/12.2578520

KEYWORDS: Spectroscopy, Tissues, Near infrared spectroscopy, Integrated optics, Atrial fibrillation, Radio optics, Associative arrays, Reconstruction algorithms, Radiofrequency ablation, Algorithm development

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Proceedings Article | 5 March 2021 Presentation

Automated adipose segmentation within cardiac optical coherence tomography images

Ziyi Huang, Yu Gan, Theresa Lye, Yanchen Liu, Andrew Laine, Elsa Angelini, Christine Hendon

Proceedings Volume 11621, 1162107 (2021) https://doi.org/10.1117/12.2578814

KEYWORDS: Image segmentation, Optical coherence tomography, Heart, Tissues, Spectral resolution, Radiofrequency ablation, Machine learning, Image resolution, Image processing algorithms and systems, Binary data

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Proceedings Article | 5 March 2021 Presentation

In-vivo demonstration of irrigated lesion morphology using near-infrared spectroscopy and artificial neural networks

Soo Young Park, Rajinder Singh-Moon, Haiqiu Yang, Vivek Iyer, Amardeep Saluja, Christine Hendon

Proceedings Volume 11631, 1163107 (2021) https://doi.org/10.1117/12.2578483

KEYWORDS: Near infrared spectroscopy, In vivo imaging, Artificial neural networks, Radiofrequency ablation, Tissues, Atrial fibrillation, Tissue optics, Spectroscopy, Optical spectroscopy

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