Digital breast tomosynthesis (DBT) is a three-dimensional (3-D) X-ray imaging modality that allows the breast to be viewed in a 3-D format, minimizing the effect of overlapping breast tissue. DBT is commonly known for its high in-plane spatial resolution allowing to detect very small structures inside the breast which makes it a powerful tool in the clinical environment. However, since DBT is a limited angle tomography, artifacts are inevitable. In this paper, we investigate the influence of the angular scanning range as well as the slice thickness, i. e. the distance between two adjacent slices, on the in-plane spatial resolution of calcifications and present an analytic model to describe the imaging process. For the validation of the analytic model, 54 datasets with varying calcification diameter, slice thickness, and angular scanning range, were used and compared to a ray-casting simulation. It could be shown that the relative mean error between the analytic model and the generated ground truth over all datatsets is ε<sup>-</sup> = 0.0137. The results indicate that both investigated parameters affect the in-plane spatial resolutio
The upsurge in interest of digital tomosynthesis is mainly caused by breast imaging; however, it finds more and more attention in orthopedic imaging as well. Offering a superior in-plane resolution compared to CT imaging and the additional depth information compared to conventional 2-D X-ray images, tomosynthesis may be an interesting complement to the other two imaging modalities. Additionally, a tomosynthesis scan is likely to be faster and the radiation dose is considerably below that of a CT. Usually, a tomosynthetic acquisition focuses only on one body part as the common acquisition techniques restrict the field-of-view. We propose a method which is able to perform full-body acquisitions with a standard X-ray system by shifting source and detector simultaneously in parallel planes without the need to calibrate the system beforehand. Furthermore, a novel aliasing filter is introduced which addresses the impact of the non-isotropic resolution during the reconstruction. We provide images obtained by filtered as well as unfiltered backprojection and discuss the influence of the scanning angle as well as the reconstruction filter on the reconstructed images. We found from the experiments that our method shows promising results especially for the imaging of anatomical structures which are usually obscured by each other since the depth resolution allows to distinguish between these structures. Additionally, as of the high isotropic in-plane spatial resolution of the tomographic volume, it is easily possible to perform precise measurements which are a crucial task, e. g. during the planning of orthopedic surgeries or the assessment of pathologies like scoliosis or subtle fractures.