Using neural probing devices implanted in the brain, neural activity from neural cells can be
recorded in-vivo for long term periods. This research goal is to develop and investigate a neural
sensing device using nanotechnology which can enhance the quality and longevity of sensing. In this
research, two neural electrode designs were employed with nanostructures, which distinguish them
from 2-dimensional planar electrode configuration. According to electrochemical simulation, high
molecular confinement has been observed on vertically aligned nanowire electrodes, especially those
with grid structures. The efficacy of the 3-dimensional nanoelectrode is also discussed in this paper,
depending on the molecular diffusion on nanoelectrodes.