Prof. Cleopatra Charalampaki Profile

Prof. Cleopatra Charalampaki

at Medical Ctr Cologne

SPIE Involvement:

Author

Publications (2)

SPIE Journal Paper | 17 May 2021 Open Access

Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings

Feredun Azari, Gregory Kennedy, Elizabeth Bernstein, Constantinos Hadjipanayis, Alexander Vahrmeijer, Barbara Smith, Eben Rosenthal, Baran Sumer, Jie Tian, Eric Henderson, Amy Lee, Quyen Nguyen, Summer Gibbs, Brian Pogue, Daniel Orringer, Cleopatra Charalampaki, Linda Martin, Janos Tanyi, Major Lee, John Y. Lee, Sunil Singhal

JBO, Vol. 26, Issue 05, 050901, (May 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.5.050901

KEYWORDS: Tumors, Surgery, Cancer, Tissues, Clinical trials, Imaging systems, Luminescence, Molecular imaging, Medicine, Near infrared

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Significance: Surgery is often paramount in the management of many solid organ malignancies because optimal resection is a major factor in disease-specific survival. Cancer surgery has multiple challenges including localizing small lesions, ensuring negative surgical margins around a tumor, adequately staging patients by discriminating positive lymph nodes, and identifying potential synchronous cancers. Intraoperative molecular imaging (IMI) is an emerging potential tool proposed to address these issues. IMI is the process of injecting patients with fluorescent-targeted contrast agents that highlight cancer cells prior to surgery. Over the last 5 to 7 years, enormous progress has been achieved in tracer development, near-infrared camera approvals, and clinical trials. Therefore, a second biennial conference was organized at the University of Pennsylvania to gather surgical oncologists, scientists, and experts to discuss new investigative findings in the field. Our review summarizes the discussions from the conference and highlights findings in various clinical and scientific trials. Aim: Recent advances in IMI were presented, and the importance of each clinical trial for surgical oncology was critically assessed. A major focus was to elaborate on the clinical endpoints that were being utilized in IMI trials to advance the respective surgical subspecialties. Approach: Principal investigators presenting at the Perelman School of Medicine Abramson Cancer Center’s second clinical trials update on IMI were selected to discuss their clinical trials and endpoints. Results: Multiple phase III, II, and I trials were discussed during the conference. Since the approval of 5-ALA for commercial use in neurosurgical malignancies, multiple tracers and devices have been developed to address common challenges faced by cancer surgeons across numerous specialties. Discussants also presented tracers that are being developed for delineation of normal anatomic structures that can serve as an adjunct during surgical procedures. Conclusions: IMI is increasingly being recognized as an improvement to standard oncologic surgical resections and will likely advance the art of cancer surgery in the coming years. The endpoints in each individual surgical subspecialty are varied depending on how IMI helps each specialty solve their clinical challenges.

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Proceedings Article | 1 May 2017 Presentation

Confocal laser endomicroscopy for brain tumor surgery: a milestone journey from microscopy to cellular surgery (Conference Presentation)

Cleopatra Charalampaki

Proceedings Volume 10060, 100600E (2017) https://doi.org/10.1117/12.2256457

KEYWORDS: Tumors, Brain, Surgery, Tissues, Biopsy, Confocal microscopy, Endomicroscopy, Laser therapeutics, Laser vision correction, Microscopy

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