Objective: To observe the efficiency and safety of hematoporphyrin mono-methylether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS) with Chinese patients, and to evaluate the advantage of photograph、VISIA-CRTM system, and dermoscopy in efficacy evaluation. Method:52 patients were treated in our hospital over the past two years with HMME-PDT ,among which, 15 cases were pink type, 29 cases were purple type and remain 8 cases were Nodular thickening type. Initially, All patients received an intravenous injection of 5 mg/kg HMME ,and then the lesion areas of the patients were exposed to 532 nm LED green light after 10 minutes. The irradiation power density was range between 80–95 mW/cm2. By utilization of photograph、VISIA-CRTM system, and dermoscopy to evaluate the clearance after treatments, and then informing the patients to rank the pain level during the treatment via VAS scale, and recording the side effects.Result:After 1-7 times treatments.13 of the 52 cases were cured (25.00%) , 14 cases showed a good efficacy (26.92%), 16 cases indicates alleviation (30.77%), while 9 cases displayed no efficacy (17.31%).By observation, it showed that the pain level each patient could endure were distinct, and it’s remarkable that when receiving consecutive 11-12min of treatment, most of patients have showed with severe pain (according to VAS scale). The side effects after treatment mainly displayed with edema，crust，hyperpigmentation.Conclusion: it shows that after treating with HMME-PDT ,the efficacy is remarkable and with advantage of safety and less side effects, which worthwhile for further research and promotion.