The multi-spectral sensor calibration system (MSSCS) is a highly automated calibration system designed around an optical table. It consists of several instruments and sources mounted on two translating tables and placed at the focus of an off-axis parabolic collimating mirror. These instruments and sources are linked to a control computer via the IEEE-488 buss. Sophisticated system control software consists of interlinked programs that provide: (1) instrument control and data acquisition, (2) automated calibration and data analysis, and (3) automated report generation. The MSSCS is used to calibrate several of NASA's airborne multi-spectral sensor systems currently in use to provide remote sensing data. These systems include the CAMS (calibrated airborne multi-spectral sensor), the ATLAS (airborne terrestrial applications sensor) and TIMS (thermal infrared multi-spectral scanner). We begin by briefly describing the overall system design with an emphasis on the objectives of the design and the capabilities provided by the complete system. This is followed by a description of how the system is aligned with the unit under test. Examples of data produced by the system are presented, and how this data was certified correct. We conclude with how the system's data products were validated.