Degradation in performance of a PV module attributable to moisture ingress has received significant attention in PV reliability research. Assessment of field performance of PV modules against moisture ingress through product-level testing in temperature-humidity control chambers poses challenges. Development of a meaningful acceleration factor model is challenging due to different rates of degradation of components embedded in a PV module, when exposed to moisture. Test results are typically a convolution of moisture barrier performance of the edge seal and degradation of laminated components when exposed to moisture. It is desirable to have an alternate method by which moisture barrier performance of the edge seal in its end product form can be assessed in any given field conditions, independent of particular cell design. In this work, a relatively inexpensive test technique was developed to test the edge seal in its end product form in a manner that is decoupled from other components of the PV module. A theoretical framework was developed to assess moisture barrier performance of edge seal with desiccants subjected to different conditions. This framework enables the analysis of test results from accelerated tests and prediction of the field performance of the edge seal. Results from this study lead to the conclusion that the edge seal on certain Miasole glass-glass modules studied is effective for the most aggressive weather conditions examined, beyond the intended service.