Dr. David A. Benaron Profile

Dr. David A. Benaron

Chief Medical Officer

SPIE Involvement:

Track Chair | Author

Publications (20)

Proceedings Article | 16 March 2023 Presentation

From zero to 1 billion: how wearable, implantable, and transmissible sensors wired our bodies and changed the world (Conference Presentation)

David Benaron

Proceedings Volume PC12387, PC1238701 (2023) https://doi.org/10.1117/12.2674077

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Proceedings Article | 19 July 2007 Paper

Intraoperative assessment of microperfusion with visible light spectroscopy in oesophageal and colorectal anastomosis

Anne Karliczek, David Benaron, Peter Baas, Anne van der Stoel, Theo Wiggers, John Plukker, Gooitzen van Dam

Proceedings Volume 6628, 66280E (2007) https://doi.org/10.1117/12.725024

KEYWORDS: Arteries, Tissues, Visible radiation, Surgery, Spectroscopy, Ischemia, Blood, Doppler effect, Tissue optics, Oximeters

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Proceedings Article | 12 July 2007 Paper

Intraoperative assessment of microperfusion with visible light spectroscopy in colorectal anastomosis

Anne Karliczek, David Benaron, Peter Baas, Anne van der Stoel, Theo Wiggers, Gooitzen van Dam

Proceedings Volume 6628, 662816 (2007) https://doi.org/10.1117/12.725022

KEYWORDS: Colon, Visible radiation, Tissues, Surgery, Spectroscopy, Ischemia, Doppler effect, Oximeters, Oxygen, Rectum

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SPIE Journal Paper | 1 July 2005 Open Access

Design of a visible-light spectroscopy clinical tissue oximeter

David Benaron, Ilian Parachikov, Wai-Fung Cheong, Shai Friedland, Boris Rubinsky, David Otten, Frank Liu, Carl Levinson, Aileen Murphy, Yair Talmi, James Weersing, Joshua Duckworth, Uwe Hörchner, Eben Kermit

JBO, Vol. 10, Issue 04, 044005, (July 2005) https://doi.org/10.1117/12.10.1117/1.1979504

KEYWORDS: Tissue optics, Tissues, Oximeters, Oximetry, Spectroscopy, Scattering, Visible radiation, Near infrared spectroscopy, In vivo imaging, Absorbance

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Proceedings Article | 14 June 2004 Paper

NIR optical probes targeting glucose transporters

Hui Li, Juan Chen, Min Zhang, Zhihong Zhang, David Benaron, Britton Chance, Jerry Glickson, Gang Zheng

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.533148

KEYWORDS: Tumors, Near infrared, Cancer, In vivo imaging, Glucose, Confocal microscopy, Luminescence, Imaging systems, Liver, Tissues

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Proceedings Article | 12 September 2003 Paper

Measurement of mucosal capillary hemoglobin oxygen saturation in the colon by reflectance spectrophotometry

Shai Friedland, David Benaron, Ilian Parachikov, Roy Soetikno

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.488351

KEYWORDS: Colon, Oxygen, Spectrophotometry, Ischemia, Reflectivity, Capillaries, Arteries, Tissues, Endoscopy, Control systems

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Proceedings Article | 29 July 2003 Paper

Quantitative clinical nonpulsatile and localized visible light oximeter: design of the T-Stat tissue oximeter

David Benaron, Ilian Parachikov, Wai-Fung Cheong, Shai Friedland, Joshua Duckworth, David Otten, Boris Rubinsky, Uwe Horchner, Eben Kermit, Frank Liu, Carl Levinson, Aileen Murphy, John Price, Yair Talmi, James Weersing

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.488596

KEYWORDS: Tissue optics, Tissues, Oximeters, Scattering, Oximetry, Spectroscopy, Light sources, Visible radiation, Light, Absorbance

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SPIE Journal Paper | 1 April 2000 Open Access

Guest Editorial: Special Issue Celebrating Britton Chance

David Benaron, Irving Bigio, Eva Sevick-Muraca, Arjun Yodh

JBO, Vol. 5, Issue 02, (April 2000) https://doi.org/10.1117/12.10.1117/1.429977

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Proceedings Article | 15 July 1999 Paper

Bedside functional imaging of the premature infant brain during passive motor activation

Susan Hintz, David Benaron, Andrew Siegel, Anna Zourabian, David Boas

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356811

KEYWORDS: Functional imaging, Brain, Neuroimaging, Sensors, Imaging systems, Single photon emission computed tomography, Optical fibers, Absorbance, Blood circulation, Oxygen

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Proceedings Article | 2 July 1999 Paper

Construction and characterization of a red-emitting luciferase

Brian Eames, David Benaron, David Stevenson, Christopher Contag

Proceedings Volume 3600, (1999) https://doi.org/10.1117/12.351042

KEYWORDS: In vivo imaging, Tissues, Tissue optics, Visible radiation, Polymers, CCD cameras, Bioluminescence, Functional imaging, Tumors, Charge-coupled devices

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Proceedings Article | 1 January 1998 Paper

Automated quantitation of tissue components using real-time spectroscopy

David Benaron, Boris Rubinski, Susan Hintz, Joshua Duckworth, Aileen Murphy, John Price, Frank Liu, David Otten, David Stevenson, Wai-Fung Cheong, Eben Kermit

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301051

KEYWORDS: Tissue optics, Spectroscopes, Tissues, Blood vessels, Absorbance, Diagnostics, Liver, Light scattering, Blood, Nerve

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Proceedings Article | 1 January 1998 Paper

Calibration of time-of-flight optical spectroscopy

Joshua Duckworth, David Benaron, Susan Hintz, Frank Liu, David Stevenson, Wai-Fung Cheong

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301037

KEYWORDS: Calibration, Optical calibration, Optical spectroscopy, Absorbance, Scattering, Algorithm development, Spectral calibration, Diffusion, Liquids, Time resolved spectroscopy

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Proceedings Article | 1 January 1998 Paper

Brain functional imaging using time-of-flight optical spectroscopy

Susan Hintz, David Benaron, Robert Robbins, Joshua Duckworth, Aileen Murphy, John Price, Frank Liu, David Stevenson, Wai-Fung Cheong

Proceedings Volume 3194, (1998) https://doi.org/10.1117/12.301050

KEYWORDS: Brain, Neuroimaging, Functional imaging, Optical spectroscopy, Oxygen, Brain activation, Signal detection, Heart, Surgery

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Proceedings Article | 29 December 1997 Paper

Automated classification of tissue by type using real-time spectroscopy

David Benaron, Wai-Fung Cheong, Joshua Duckworth, Kenneth Noles, Camran Nezhat, Daniel Seidman, Susan Hintz, Carl Levinson, Aileen Murphy, John Price, Frank Liu, David Stevenson, Eben Kermit

Proceedings Volume 3197, (1997) https://doi.org/10.1117/12.297957

KEYWORDS: Tissues, Tissue optics, Absorbance, Biopsy, Kidney, Light sources, Medicine, Uterus, Statistical analysis, Light scattering

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SPIE Journal Paper | 1 October 1996 Open Access

Guest Editorial: Special Section on Near Infrared Spectroscopy and Imaging of Tissues

Marco Ferrari, David Delpy, David Benaron

JBO, Vol. 1, Issue 04, (October 1996) https://doi.org/10.1117/12.10.1117/12.256755

KEYWORDS: Near infrared spectroscopy, Tissues, Imaging spectroscopy, Brain, Breast, Head, Prototyping, Spectroscopy, Scattering, Natural surfaces

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Proceedings Article | 30 May 1995 Paper

Early clinical results of time-of-flight optical tomography in a neonatal intensive care unit

David Benaron, John Van Houten, Wai-Fung Cheong, Eben Kermit, Richard King

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209949

KEYWORDS: Brain, Tissues, Absorbance, Blood, Scattering, Neuroimaging, Injuries, Tissue optics, Head, Spectroscopy

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Proceedings Article | 30 March 1995 Paper

Laser imaging for clinical applications

John Van Houten, Wai-Fung Cheong, Eben Kermit, Richard King, Stanley Spilman, David Benaron

Proceedings Volume 2390, (1995) https://doi.org/10.1117/12.206000

KEYWORDS: Brain, Tissues, Injuries, Neuroimaging, Blood, Scattering, Light scattering, Tissue optics, Traumatic brain injury, Optical imaging

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Proceedings Article | 14 September 1993 Paper

Imaging (NIRI) and quantitation (NIRS) in tissue using time-resolved spectrophotometry: the impact of statistically and dynamically variable optical path lengths

David Benaron, David Ho, Boris Rubinsky, Mark Shannon

Proceedings Volume 1888, (1993) https://doi.org/10.1117/12.154644

KEYWORDS: Tissue optics, Near infrared, Absorbance, Brain, Systems modeling, Blood, Imaging spectroscopy, Tissues, Tumors, Spectroscopy

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Proceedings Article | 5 August 1993 Paper

A medical perspective at the threshold of clinical optical tomography

David Benaron

Proceedings Volume 10311, 1031102 (1993) https://doi.org/10.1117/12.2283747

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Proceedings Article | 6 May 1992 Paper

Two-dimensional and 3-D images of thick tissue using time-constrained times-of-flight and absorbance spectrophotometry

David Benaron, M. Lennox, David Stevenson

Proceedings Volume 1641, (1992) https://doi.org/10.1117/12.59375

KEYWORDS: Photons, Scattering, Absorbance, Tissue optics, Tissues, Blood, Light scattering, Sensors, Pulsed laser operation, Fetus

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Reconstructing deep-tissue images in real time using spectrophotometric data from optically diffusing thick tissues has been problematic. Continuous wave applications (e.g., pulse oximetry, regional cerebral saturation) ignore both the multiple paths traveled by the photons through the tissue and the effects of scattering, allowing scalar measurements but only under limited conditions; interferometry works poorly in thick, highly-scattering media; frequency- modulated approaches may not allow full deconvolution of scattering and absorbance; and pulsed-light techniques allow for preservation of information regarding the multiple paths taken by light through the tissue, but reconstruction is both computation intensive and limited by the relative surface area available for detection of photons. We have developed a picosecond times-of-flight and absorbance (TOFA) optical system, time-constrained to measure only photons with a narrow range of path lengths and arriving within a narrow angel of the emitter-detector axis. The delay until arrival of the earliest arriving photons is a function of both the scattering and absorbance of the tissues in a direct line between the emitter and detector, reducing the influence of surrounding tissues. Measurement using a variety of emitter and detector locations produces spatial information which can be analyzed in a standard 2-D grid, or subject to computer reconstruction to produce tomographic images representing 3-D structure. Using such a technique, we have been able to demonstrate the principles of tc-TOFA, detect and localize diffusive and/or absorptive objects suspended in highly scattering media (such as blood admixed with yeast), and perform simple 3-D reconstructions using phantom objects. We are now attempting to obtain images in vivo. Potential future applications include use as a research tool, and as a continuous, noninvasive, nondestructive monitor in diagnostic imaging, fetal monitoring, neurologic and cardiac assessment. The technique may lead to real-time optical imaging and quantitation of tissues oxygen delivery.