Dr. David D. D. Nolte
Professor of Physics and Astronomy at Purdue Univ
SPIE Involvement:
Author | Instructor
Publications (69)

SPIE Journal Paper | 29 March 2021
JBO Vol. 26 Issue 03

SPIE Journal Paper | 22 September 2020
JBO Vol. 25 Issue 09

Proceedings Article | 10 March 2020 Presentation
Proc. SPIE. 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020
KEYWORDS: Doppler effect, Tissues, Imaging technologies, Spectroscopy, Imaging spectroscopy, Functional imaging, Therapeutics, Tissue optics, Motion measurement, Environmental sensing

Proceedings Article | 19 July 2019 Paper
Proc. SPIE. 11073, Clinical and Preclinical Optical Diagnostics II
KEYWORDS: Cancer, Digital holography, Tumors, Tissues, Biopsy, Profiling, Therapeutics, Doppler tomography, Ovarian cancer, Clinical trials

SPIE Journal Paper | 25 June 2019
JBO Vol. 24 Issue 06
KEYWORDS: Acquisition tracking and pointing, Microscopes, Control systems, Statistical analysis, Digital holography, Coherence imaging, Lithium, Doppler effect, Bioluminescence, Dynamic light scattering

Showing 5 of 69 publications
Conference Committee Involvement (1)
Ultrafast Phenomena in Semiconductors VII
29 January 2003 | San Jose, CA, United States
Course Instructor
SC1054: Bio-Interferometry: Fundamentals and Applications to Biosensors, Drug Discovery, Microscopy and Biomedical Imaging
This course explains the basic principles of optical interferometry applied to biological problems and systems. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure such as for interference microscopy and optical coherence tomography. Interference is also the root cause of speckle and other imaging artifacts that limit range and resolution. Furthermore, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics using biosensors. In this course, emphasis is placed on the physics of light scattering, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds. <p> </p>Bio-Interferometry is divided into four parts. The first part covers fundamental principles of partial coherence and interferometry. The next three parts move up successive size scales: biosensors and molecular interferometry (nano-scale), cellular interferometry and microscopy (micron-scale), and ending with tissue interferometry and holography (millimeter scale). The course clearly presents the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions.
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