Dr. David D. Nolte
Professor of Physics at Purdue Univ
SPIE Involvement:
Conference Program Committee | Author | Instructor
Publications (64)

PROCEEDINGS ARTICLE | March 15, 2018
Proc. SPIE. 10504, Biophysics, Biology and Biophotonics III: the Crossroads
KEYWORDS: Cancer, Digital holography, Tissues, Optical coherence tomography, Spectroscopy, Light scattering, Dynamic light scattering, Tissue optics, Doppler tomography, Biophysics

PROCEEDINGS ARTICLE | February 20, 2018
Proc. SPIE. 10501, Optical Diagnostics and Sensing XVIII: Toward Point-of-Care Diagnostics
KEYWORDS: Signal to noise ratio, Photodetectors, Diffraction, Optical design, Point-of-care devices, Spatial frequencies, Diagnostics, Biosensors, Semiconducting wafers, Diffraction gratings

PROCEEDINGS ARTICLE | February 13, 2018
Proc. SPIE. 10493, Dynamics and Fluctuations in Biomedical Photonics XV
KEYWORDS: Digital image processing, Cancer, Coherence (optics), Speckle, Light scattering, Biopsy, Speckle pattern, Lymphoma, Tissue optics, Chemical elements

PROCEEDINGS ARTICLE | February 7, 2018
Proc. SPIE. 10472, Diagnosis and Treatment of Diseases in the Breast and Reproductive System IV
KEYWORDS: Scattering, Light scattering, Dynamic light scattering, In vitro testing

PROCEEDINGS ARTICLE | March 3, 2017
Proc. SPIE. 10063, Dynamics and Fluctuations in Biomedical Photonics XIV
KEYWORDS: Optical imaging, Holograms, Stars, 3D image reconstruction, Digital holography, Doppler effect, Tissues, Imaging systems, Cameras, Spectroscopy, Imaging spectroscopy, Numerical simulations, Specular reflections, Optical interferometry, Tissue optics, 3D image processing

SPIE Journal Paper | January 9, 2017
JBO Vol. 22 Issue 01
KEYWORDS: Tissues, 3D image processing, Tissue optics, Tumors, Profiling, 3D metrology, Digital holography, Biopsy, Cancer, Speckle

Showing 5 of 64 publications
Conference Committee Involvement (1)
Ultrafast Phenomena in Semiconductors VII
29 January 2003 | San Jose, CA, United States
Course Instructor
SC1054: Bio-Interferometry: Fundamentals and Applications to Biosensors, Drug Discovery, Microscopy and Biomedical Imaging
This course explains the basic principles of optical interferometry applied to biological problems and systems. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure such as for interference microscopy and optical coherence tomography. Interference is also the root cause of speckle and other imaging artifacts that limit range and resolution. Furthermore, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics using biosensors. In this course, emphasis is placed on the physics of light scattering, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds. <p> </p>Bio-Interferometry is divided into four parts. The first part covers fundamental principles of partial coherence and interferometry. The next three parts move up successive size scales: biosensors and molecular interferometry (nano-scale), cellular interferometry and microscopy (micron-scale), and ending with tissue interferometry and holography (millimeter scale). The course clearly presents the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions.
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