Spherical microresonators have been demonstrated to be potential label-free tools for identifying chemical species on the
sub-nanoscale level. Here a novel sensor based on the high-Q spherical microresonators will be presented. Recently, it
was demonstrated that WGM spherical microresonators provide surface second harmonic light generation from a low
number of small molecules . The sensor signal is in this case directly related to the chemical distribution found at the
surface. Results will be presented for the proof of principle of a new device integrated by an inert material onto which a
periodic patterning is lithographically imprinted allowing the WGM generation of the second harmonic of only those
analyte molecules attached to the imprinted area. The realistic implementation of the device will be discussed, as well as
its prospective capabilities for bio- and chemical-sensing for large and small molecules.