SrAl<sub>2</sub>O<sub>4</sub>: Eu<sup>2+</sup>, Dy<sup>3+</sup> nanoparticles prepared by pulsed laser ablation in liquids (PLAL) could be a green and versatile technique to obtain inorganic nanoparticles with persistent luminescence and different morphologies and sizes. Laser ablation technique could deliver large amounts of energy highly concentrated into one point of a material and has been carried out in vacuum, in air and in liquids. Because of the unique confinement effect from liquid environment, there is many advantages when the laser ablation occurs in liquid. In this paper, we focus on the control of the size through proper laser parameters, choice of the reaction solution. Persistent luminescent SrAl<sub>2</sub>O<sub>4</sub>: Eu<sup>2+</sup>, Dy<sup>3+</sup> phosphor was obtained by laser ablation in liquids.