This paper analyzes the inherent contradictions that exist in most of the conventional approaches dealing with airplane hijacking, and presents a completely different approach, employing innovative technological and operational solution. The suggested techno-operational concept is derived from the Systematic Inventive Thinking (SIT) methodology which enforces the problem solver to search for a solution under a few constraining rules -- causing the solution (if found) to be very cost effective. The basic problem that arises from most existing conventional concepts is their very poor cost
effectiveness. Passengers, airport operators and aviation companies are all forced to invest on a continual basis, huge amounts of resources and time in order to prevent a hijacking event. The "Auto Immune" concept, discussed here, is based upon enlisting the passengers (in a case of "Hijacking Event" only) to foil the event successfully by releasing, in real-time, a very effective "One-time Non-Lethal Apparatus" (ONLA). This new paradigm changes dramatically the balance of power in favor of the "good guys", and the few hijackers will be neutralized at low risk to the passengers and
the aircraft. The detailed technological and operational concept is described, including: operation modes of ONLA, location, release method, safety issues, psychological and legal issues, etc.