Over the last 25 years, the number of papers written that involve image guidance, liver, and registration has, on average, doubled every 6-8 years. While image guidance has a long history within the neurosurgical theatre, it’s translation to other soft-tissue organs such as the liver has been slower given the inherent difficulty in image-to-physical registration. More specifically, deformations have been recognized to compromise image guidance fidelity in virtually all soft-tissue image guidance applications. As a result, an active area of investigation is the development of sparse-data-driven nonrigid image-to-physical liver registration techniques to compensate for deformation and provide accurate localization for image guided liver surgery. In this work we have leveraged our extensive human-to-phantom registration testing framework based on the work in  and Amazon Web Services to create a sparse data challenge for the image guided liver surgery community (https://sparsedatachallenge.org/). Our sparse data challenge will allow research groups from across the world to extensively test their approaches on common data and have quantitative accuracy measurements provided for assessment of fidelity. Welcome to the Sparse Data Challenge for image-to-physical liver registration assessment.