Dr. Edwin M. Westbrook Profile

Dr. Edwin M. Westbrook

Director

SPIE Involvement:

Author | Instructor

Proceedings Article | 20 January 2004 Paper

Advances in CCD technology for x-ray diffraction applications

Timothy Thorson, Roger Durst, Dan Frankel, Rex Bordwell, Jose Camara, Edward Leon-Guerrero, Steven Onishi, Francis Pang, Paul Vu, Edwin Westbrook

Proceedings Volume 5198, (2004) https://doi.org/10.1117/12.505710

KEYWORDS: Cameras, Charge-coupled devices, Sensors, X-ray diffraction, CCD cameras, Back illuminated sensors, CCD image sensors, Electrons, Imaging systems, Electronics

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Proceedings Article | 10 January 2003 Paper

3DX: a micromachined silicon crystallographic x-ray detector

John Morse, Christopher Kenney, Edwin Westbrook, Istvan Naday, Sherwood Parker

Proceedings Volume 4784, (2003) https://doi.org/10.1117/12.451164

KEYWORDS: Sensors, Silicon, Electrodes, X-rays, X-ray detectors, Crystals, Semiconducting wafers, Crystallography, Oxides, Etching

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Proceedings Article | 10 January 2003 Paper

Design and characterization of a large-area lens-coupled CCD detector for macromolecular crystallography

Edwin Westbrook, John Morse, Robert Fischer, William McGuigan, Steven Onishi, Paul Vu, Istvan Naday, C. Bauer, J. Phillips, T. Thorson, Roger Durst

Proceedings Volume 4784, (2003) https://doi.org/10.1117/12.451165

KEYWORDS: Sensors, Fiber optics, Charge-coupled devices, Energy efficiency, Fiber optics sensors, Energy transfer, CCD image sensors, Lens design, Prototyping, X-rays

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Proceedings Article | 6 October 1999 Paper

Performance characteristics needed for protein crystal diffraction x-ray detectors

Edwin Westbrook

Proceedings Volume 3774, (1999) https://doi.org/10.1117/12.367113

KEYWORDS: Sensors, Crystals, Diffraction, Charge-coupled devices, Synchrotrons, X-rays, Proteins, X-ray detectors, Silicon, CCD image sensors

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Proceedings Article | 6 October 1999 Paper

Operational experience of a large-area x-ray camera for protein crystallography

Istvan Naday, R. Sanishvili, A. Joachimiak, Edwin Westbrook, Anthony Jorden, Paul Loeffen

Proceedings Volume 3774, (1999) https://doi.org/10.1117/12.367124

KEYWORDS: Sensors, Charge-coupled devices, Diffraction, X-rays, Crystallography, Crystals, Proteins, CCD image sensors, Data acquisition, X-ray detectors

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SPIE Journal Paper | 1 April 1998

Charge-coupled device/fiber optic taper array x-ray detector for protein crystallography

Istvan Naday, Stephan Ross, Edwin Westbrook, George Zentai

OE, Vol. 37, Issue 04, (April 1998) https://doi.org/10.1117/12.10.1117/1.601789

KEYWORDS: Sensors, Charge-coupled devices, X-rays, X-ray detectors, CCD image sensors, Proteins, Crystals, X-ray imaging, Crystallography, Diffraction

Proceedings Article | 25 April 1997 Paper

Charge-coupled-device fiber optic taper array x-ray detector for protein crystallography

Istvan Naday, Stephan Ross, Edwin Westbrook, George Zentai

Proceedings Volume 3019, (1997) https://doi.org/10.1117/12.275187

KEYWORDS: Sensors, Charge-coupled devices, X-rays, X-ray detectors, Fiber optics, CCD image sensors, Proteins, Crystallography, X-ray imaging, Diffraction

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Proceedings Article | 10 April 1995 Paper

Amorphous silicon area detectors for protein crystallography

Stephan Ross, Istvan Naday, Miklos Kanyo, Mary Westbrook, Edwin Westbrook, Walter Phillips, Martin Stanton, Robert Street

Proceedings Volume 2415, (1995) https://doi.org/10.1117/12.206516

KEYWORDS: Sensors, Crystals, Charge-coupled devices, CCD image sensors, X-rays, Amorphous silicon, Diffraction, Proteins, Crystallography, X-ray detectors

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Proceedings Article | 10 April 1995 Paper

Gold detector: modular CCD area detector for macromolecular crystallography

Istvan Naday, Stephan Ross, Miklos Kanyo, Mary Westbrook, Edwin Westbrook, Walter Phillips, Martin Stanton, Daniel O'Mara

Proceedings Volume 2415, (1995) https://doi.org/10.1117/12.206519

KEYWORDS: Sensors, X-rays, CCD image sensors, Charge-coupled devices, Crystals, Gold, X-ray detectors, Diffraction, Crystallography, Signal detection

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We have designed, fabricated, and tested a modular CCD area detector system for macromolecular crystallography at synchrotron x-ray sources, code-named the `gold' detector system. The sensitive area of the detector is 150 mm X 150 mm, with 3,072 X 3,072 pixel sampling, resulting in roughly a 50 micrometers pixel raster. The x-ray image formed on the face of the detector is converted to visible light by a thin phosphor layer. This image is transferred optically to nine CCD sensors by nine square fiberoptic tapers (one for each CCD), arranged in a 3 X 3 array. Each taper demagnifies the image by a factor of approximately 2. Each CCD has a 1,024 X 1,024 pixel raster and is read out through two independent data channels. After each x-ray exposure period the x-ray shutter is closed and the electronic image is digitized (16-bit) and read out in 1.8s. Alteratively, the image may be binned 2 X 2 during readout, resulting in a 1,536 X 1,536 raster of 100 micrometers pixels; this image can be read out in 0.4s. The CCD sensors are operated at -40 degree(s)C to reduce electronic noise. The detector is operated under full computer control: all operational parameters (readout rates, CCD temperature, etc.) can be adjusted from the console. The image data (18 MByte/image) are transferred via a fast VME system to a control processor and ultimately to disk storage. During April 1994 we carried out a complete set of measurements at the Stanford Synchrotron Radiation Laboratory (SSRL) for a full characterization of the gold detector. Characterization includes quantitative evaluation of the instrument's conversion gain (signal level/x-ray photon); detective quantum efficiency (DQE); point-spread function; sensitivity as a function of x-ray energy; geometrical distortion of images; spatial uniformity; read noise; and dark image and dark image noise. Characterization parameters derived from these measurements show that this detector will be extraordinarily valuable for macromolecular crystallography.

Proceedings Article | 16 December 1993 Paper

CCD-based detector for crystallographic applications using laboratory x-ray sources

Walter Phillips, Martin Stanton, Daniel O'Mara, Youli Li, Istvan Naday, Edwin Westbrook

Proceedings Volume 2009, (1993) https://doi.org/10.1117/12.164732

KEYWORDS: Sensors, Charge-coupled devices, X-rays, X-ray detectors, CCD image sensors, Fiber optics, CCD cameras, Crystals, X-ray sources, Crystallography

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Proceedings Article | 12 July 1993 Paper

Modular CCD detector for x-ray crystallography

Walter Phillips, Martin Stanton, Daniel O'Mara, Istvan Naday, Edwin Westbrook

Proceedings Volume 1900, (1993) https://doi.org/10.1117/12.148747

KEYWORDS: Sensors, X-rays, Charge-coupled devices, X-ray detectors, CCD image sensors, Fiber optics, Crystallography, Photons, X-ray diffraction, Crystals

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Proceedings Article | 12 August 1992 Paper

Design criteria and development of components for a modular CCD-based detector for x-ray crystallography

Daniel O'Mara, Wilfried Philips, Martin Stanton, Daniel Saroff, Istvan Naday, Edwin Westbrook

Proceedings Volume 1656, (1992) https://doi.org/10.1117/12.135946

KEYWORDS: Fiber optics, Sensors, X-rays, Epoxies, Charge-coupled devices, X-ray detectors, Back illuminated sensors, X-ray imaging, Image intensifiers, Reflectors

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Proceedings Article | 1 July 1991 Paper

Large-aperture CCD x-ray detector for protein crystallography using a fiber-optic taper

Michael Strauss, Edwin Westbrook, Istvan Naday, Tom Coleman, Mary Westbrook, Dale Travis, Robert Sweet, J. Pflugrath, Martin Stanton

Proceedings Volume 1447, (1991) https://doi.org/10.1117/12.45312

KEYWORDS: Sensors, Charge-coupled devices, X-rays, Crystals, Diffraction, CCD image sensors, X-ray detectors, Image intensifiers, Proteins, Fiber optics

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Showing 5 of 13 publications

SPIE Conference Volume | 10 January 2003

X-Ray and Gamma-Ray Detectors and Applications IV

SPIE Conference Volume | 10 January 2003

X-Ray and Gamma-Ray Detectors and Applications IV

SPIE Conference Volume | 6 October 1999

Detectors for Crystallography and Diffraction Studies at Synchrotron Sources

Conference Committee Involvement (5)

Ultrafast X-Ray Detectors and Applications II

31 July 2005 | San Diego, California, United States

Ultrafast X-Ray Detectors and Applications

6 August 2003 | San Diego, California, United States

X-Ray and Gamma-Ray Detectors and Applications IV

8 July 2002 | Seattle, WA, United States

X-Ray Detectors

7 July 2002 | Seattle, WA, United States

Detectors for Crystallography and Diffraction Studies at Synchrotron Sources

19 July 1999 | Denver, CO, United States

Course Instructor

SC408: Crystallographic X-Ray Detector Technology

This course compares and contrasts a variety of technologies that can be applied to the design and manufacture of detectors for the crystallographic analysis of biological macromolecules. Successful existing detector systems are studied to examine what attributes are required for a good detector in this field. The course examines where improvements can be made with existing technologies, and identifies new technologies showing promise for future development. In particular, design attributes that make a good detector for applications at synchrotron sources are contrasted to those attributes that make a good detector on a laboratory X-ray source.

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