Ms. Eileen S. Flores Profile

Eileen S. Flores

Research Project Coordinator at Memorial Sloan Kettering Cancer Ctr

SPIE Involvement:

Author

Publications (3)

Proceedings Article | 6 February 2017 Presentation + Paper

Peri-operative imaging of cancer margins with reflectance confocal microscopy during Mohs micrographic surgery: feasibility of a video-mosaicing algorithm

Eileen Flores, Oriol Yelamos, Miguel Cordova, Kivanc Kose, William Phillips, Anthony Rossi, Kishwer Nehal, Milind Rajadhyaksha

Proceedings Volume 10037, 100370B (2017) https://doi.org/10.1117/12.2252440

KEYWORDS: Cancer, Surgery, Reflectivity, Confocal microscopy, Mohs surgery, Skin cancer, Video, Skin, Tumors, Visualization

Read Abstract +

Reflectance confocal microscopy (RCM) imaging shows promise for guiding surgical treatment of skin cancers. Recent technological advancements such as the introduction of the handheld version of the reflectance confocal microscope, video acquisition and video-mosaicing have improved RCM as an emerging tool to evaluate cancer margins during routine surgical skin procedures such as Mohs micrographic surgery (MMS). Detection of residual non-melanoma skin cancer (NMSC) tumor during MMS is feasible, as demonstrated by the introduction of real-time perioperative imaging on patients in the surgical setting. Our study is currently testing the feasibility of a new mosaicing algorithm for perioperative RCM imaging of NMSC cancer margins on patients during MMS. We report progress toward imaging and image analysis on forty-five patients, who presented for MMS at the MSKCC Dermatology service. The first 10 patients were used as a training set to establish an RCM imaging algorithm, which was implemented on the remaining test set of 35 patients. RCM imaging, using 35% AlCl₃ for nuclear contrast, was performed pre- and intra-operatively with the Vivascope 3000 (Caliber ID). Imaging was performed in quadrants in the wound, to simulate the Mohs surgeon’s examination of pathology. Videos were taken at the epidermal and deep dermal margins. Our Mohs surgeons assessed all videos and video-mosaics for quality and correlation to histology. Overall, our RCM video-mosaicing algorithm is feasible. RCM videos and video-mosaics of the epidermal and dermal margins were found to be of clinically acceptable quality. Assessment of cancer margins was affected by type of NMSC, size and location. Among the test set of 35 patients, 83% showed acceptable imaging quality, resolution and contrast. Visualization of nuclear and cellular morphology of residual BCC/SCC tumor and normal skin features could be detected in the peripheral and deep dermal margins. We observed correlation between the RCM videos/video-mosaics and the corresponding histology in 32 lesions. Peri-operative RCM imaging shows promise for improved and faster detection of cancer margins and guiding MMS in the surgical setting.

SPIE Journal Paper | 23 February 2015 Open Access

Intraoperative imaging during Mohs surgery with reflectance confocal microscopy: initial clinical experience

Eileen Flores, Miguel Cordova, Kivanc Kose, William Phillips, Anthony Rossi, Kishwer Nehal, Milind Rajadhyaksha

JBO, Vol. 20, Issue 06, 061103, (February 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.6.061103

KEYWORDS: Video, Tumors, Mohs surgery, Skin, Confocal microscopy, Reflectivity, Microscopes, Pathology, Aluminum, Tissues

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 4 March 2014 Paper

Feasibility of intraoperative imaging during Mohs surgery with reflectance confocal microscopy

Eileen Flores, Miguel Cordova, Kivanc Kose, William Phillips, Kishwer Nehal, Milind Rajadhyaksha

Proceedings Volume 8926, 89260F (2014) https://doi.org/10.1117/12.2039590

KEYWORDS: Video, Tumors, Mohs surgery, Skin, Pathology, Reflectivity, Confocal microscopy, Video processing, Biopsy, Tissues

Read Abstract +

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years