Combination of FTIR spectroscopy with fiber optics provides a powerful diagnostic tool for diagnosing of human diseases, including osteoarthritis. To detect cartilage degradation, an arthroscopic probe based on polycrystalline fibers was developed and evaluated on equine cartilage specimen. The hook shape allows reaching a significant portion of the articular surface; the flat tip ensures avoidance of tissue destruction. Efficient QCL-coupling and stable transmission of PIR fibers under bending allows the assembling of effective thin arthroscopy probes and customized multispectral systems for medical diagnostic applications. The presented work was performed within the MIRACLE project (Grant Agreement No 780598, Horizon 2020).
Single and combined fiber optic probes for key spectroscopy methods (Raman scattering, Mid IR-absorption, Diffuse NIR-reflection, and auto-fluorescence) were compares to detect malignant tissue in clinical environment. All four methods were tested on cancer diagnostics on biopsies (stomach, colon and kidney) and bioliquids (serum, plasma and urine) of patients.