Damage evolution in ductile metals is characterized by the nucleation, growth and coalescence of small internal voids. Many laws and studies have been developed to understand and predict damage. Numerical modeling, based on full field microstructure acquisition have proven also to be quite efficient. Real microstructure input are of utmost importance as some studies have shown that the deviation from the average behavior for voids growth can be huge and therefore allows a single cavity to drive the damage behavior and lead to failure. We develop the dedicated tool to analyze individually voids during in situ test and use results as input for numerical simulations.