Proceedings Article | 24 March 2016
Proc. SPIE. 9787, Medical Imaging 2016: Image Perception, Observer Performance, and Technology Assessment
KEYWORDS: Cancer, Breast cancer, Visualization, Tissues, Magnetic resonance imaging, Image segmentation, X-rays, Mammography, Model-based design, Digital breast tomosynthesis
<strong>PURPOSE:</strong> To assess the performance of Quantra<sup>TM</sup> in reproducing BI-RADS<sup>®</sup> mammographic breast density (MBD) assessment. <strong>METHODS:</strong> Two methods of MBD assessment were used (Quantra<sup>TM</sup> and BI-RADS<sup>®</sup>). Volumetric breast density measurement from 292 raw projection images was performed using Quantra<sup>TM</sup>. BI-RADS<sup>®</sup> assessment was performed by three radiologists and a majority report (consensus of at least two radiologists) was generated. Interreader agreement (κ), agreement, and the sensitivity and specificity of Quantra<sup>TM</sup> in reproducing BI-RADS<sup>®</sup> rating were calculated on a four-grade (1, 2, 3, and 4) and two-grade (1–2 vs. 3–4) scale. <strong>RESULTS:</strong> The majority BI-RADS<sup>®</sup> report in the dataset consisted of 9.6% (n = 28), 35.3% (n = 103), 27.1% (n = 79), and 28.1% (n = 82) for BI-RADS® 1, 2, 3, and 4 respectively. Intra-reader agreement (κ) was 0.86 (95%CI: 0.83 – 0.91) to 0.88 (95%CI: 0.85 – 0.93) on a four-grade and 0.88 (95%CI: 0.83 – 0.92) to 0.91 (95%CI: 0.88 – 0.95) on a two-grade scale. Inter-reader agreement (κ) was substantial [0.66 (95%CI: 0.62 – 0.71) to 0.75 (95%CI: 0.70 – 0.81)] on a four-grade scale and substantial to almost perfect [0.77 (95%CI: 0.73 – 0.82) to 0.89 (95%CI: 0.84 – 0.93)] on a two-grade scale. Quantra<sup>TM</sup> correctly classified 35.7%, 91.2%, 88.6%, and 50.3% of BI-RADS<sup>®</sup> 1, 2, 3, and 4 respectively. It also demonstrated 91.3% sensitivity and 83.6% specificity in reproducing BI-RADS<sup>®</sup> on a two-grade scale (1–2 vs. 3–4). <strong>CONCLUSION:</strong> Quantra<sup>TM</sup> has limited performance in reproducing BI-RADS<sup>®</sup> rating on a four-grade scale, however, highly reproduces BI-RADS<sup>®</sup> assessment on a two-grade scale.
