Mr. Eungjun Youn Profile

Eungjun Youn

at Yonsei Univ

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Proceedings Article | 9 February 2012 Paper

Determination of optimal glycerol concentration for optical tissue clearing

Eungjun Youn, Taeyoon Son, Han-Sung Kim, Byungjo Jung

Proceedings Volume 8207, 82070J (2012) https://doi.org/10.1117/12.909790

KEYWORDS: Collagen, Tissue optics, Optical coherence tomography, Skin, Tissue clearing, Laser scattering, Reflectivity, Transmittance, Ultrasonography, Light scattering

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The laser scattering in tissue is significant in diagnostic and therapeutic purposes of laser. Many studies have been conducted to minimize laser scattering in tissue and therefore, to maximize the clinical efficacy by enhancing photon density. Optical clearing agents (OCAs) have been employed for optical tissue clearing (OTC). This study was aimed to investigate the optimal concentration of an OCA, glycerol, in topical application,, so that it can be utilized for clinical diagnosis and therapy in dermatology. Glycerol was topically applied to avoid possible edema caused by dermal injection. The effect of OTC was quantitatively evaluated as a function of the concentration of glycerol with various methods. Optical methods such as optical coherence tomography (OCT) and an integrating sphere were used to assess the enhancement of light penetration depth and refractive index matching. In addition, a non-optical method, ultrasound scanner, was utilized to evaluate quantitatively collagen dissociation. The results revealed that 70 % glycerol was the optimal concentration of OTC for topical application. This study may provide a guideline regarding to the use of glycerol for optimal diagnostic and therapeutic effects in dermatology.

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