Acupuncture has a long history of more than 2000 years in China. However, traditional acupuncture adopts metallic needles which may bring discomfort and pricking to patients. Laser acupuncture (LA) is a non-invasive and painless way to achieve some therapeutic effects. And compared to traditional acupuncture, LA is free from infection. Taking these advantages of LA into consideration, we innovatively developed a portable laser acupuncture device with therapy part and detection part together. Therapy part sends out laser at the wavelength of 650 nm onto special acupoints of patients. And detection part includes integrated light-emitting diode (LED, 735/805/850 nm) and photodiode (OPT101). The detection part is used for the data collection for calculation of hemodynamic parameters based on near-infrared spectroscopy (NIRS). In this work, we carried out current-power test for sensitivity of therapy part. And we also conducted liquid-model optical experiment and arm blocking test for the sensitivity and effectiveness of detection part. The final results demonstrated great potential and reliability of the novel laser acupuncture device. In the future, we will apply this device in clinical applications to verify the effectiveness of the device and improve the reliability for more treatment of diseases.
Proc. SPIE. 10066, Energy-based Treatment of Tissue and Assessment IX
KEYWORDS: Light emitting diodes, Laser therapeutics, Tissues, Blood, 3D modeling, Monte Carlo methods, Head, In vivo imaging, 3D displays, Low level phototherapy, Absorption, Brain, Clinical trials, Animal model studies
Stroke is a devastating disease, which is the third leading cause of death and disability worldwide. Although the incidence of stroke increases progressively with age, morbidity among young and middle-aged adults is increasing annually. Medications nevertheless remain the bulwarks of stroke. The treatment is ineffective, speculative and has a long treatment cycle. The function of acupuncture and moxibustion, which are potential therapeutic tools for stroke, is still controversial. Recently, Low-level light therapy (LLLT) has been demonstrated potent in vivo efficacy for treatment of ischemic conditions of acute myocardial infraction and stroke in multiple validated animal models. Optimum LLLT treatment has a dominant influence on therapy of stroke. While more than a thousand clinical trials have been halted, only a few trials on animals have been reported. We addressed this issue by simulating near-infrared light propagation with accurate visible Chinese human head by Monte Carlo modeling. The visible human head embody region of atherosclerotic plaques in head. Through comparing the light propagation of different light illumination, we can get a precise, optimized and straightforward treatment. Here, we developed a LLLT helmet for treating stroke depend on near-infrared light. There are more than 30 LED arrays in in multi-layered 3D printed helmet. Each LED array has independent water-cooling module and can be adjusted to touch the head of different subjects based on Electro pneumatic module. Moreover, the software provides the setup of illumination parameters and 3D distribution of light fluence rate distribution in human brain.
Laser acupuncture is an effective photochemical and nonthermal stimulation of traditional acupuncture points with lowintensity
laser irradiation, which is advantageous in painless, sterile, and safe compared to traditional acupuncture. Laser
diode (LD) provides single wavelength and relatively-higher power light for phototherapy. The quantitative effect of
illumination parameters of LD in use of laser acupuncture is crucial for practical operation of laser acupuncture.
However, this issue is not fully demonstrated, especially since experimental methodologies with animals or human are
pretty hard to address to this issue. For example, in order to protect viability of cells and tissue, and get better therapeutic
effect, it’s necessary to control the output power varied at 5mW~10mW range, while the optimized power is still not
clear. This study aimed to quantitatively optimize the laser output power, wavelength, and irradiation direction with
highly realistic modeling of light transport in acupunctured tissue. A Monte Carlo Simulation software for 3D vowelized
media and the highest-precision human anatomical model Visible Chinese Human (VCH) were employed. Our 3D
simulation results showed that longer wavelength/higher illumination power, larger absorption in laser acupuncture; the
vertical direction emission of the acupuncture laser results in higher amount of light absorption in both the acupunctured
voxel of tissue and muscle layer. Our 3D light distribution of laser acupuncture within VCH tissue model is potential to
be used in optimization and real time guidance in clinical manipulation of laser acupuncture.
Brain death, the irreversible and permanent loss of the brain and brainstem functions, is hard to be judged precisely for some clinical reasons. The traditional diagnostic methods are time consuming, expensive and some are even dangerous. Functional near infrared spectroscopy (FNIRS), using the good scattering properties of major component of blood to NIR, is capable of noninvasive monitoring cerebral hemodynamic responses. Here, we attempt to use portable FNIRS under patients’ natural state for brain death diagnosis. Ten brain death patients and seven normal subjects participated in FNIRS measurements. All of them were provided different fractional concentration of inspired oxygen (FIO<sub>2</sub>) in different time periods. We found that the concentration variation of deoxyhemoglobin concentration (Δ[Hb]) presents the trend of decrease in the both brain death patients and normal subjects with the raise of the FIO<sub>2</sub>, however, the data in the normal subjects is more significant. And the concentration variation of oxyhemoglobins concentration (Δ[HbO<sub>2</sub>]) emerges the opposite trends. Thus Δ[HbO<sub>2</sub>]/Δ[Hb] in brain death patients is significantly higher than normal subjects, and emerges the rising trend as time went on. The findings indicated the potential of FNIRS-measured hemodynamic index in diagnosing brain death.