Prof. Gang Zheng Profile

Prof. Gang Zheng

Sr Scientist at Princess Margaret Cancer Centre

SPIE Involvement:

Author

Publications (28)

Proceedings Article | 13 March 2024 Presentation

Detection of atherosclerotic plaques with nanoparticles as contrast agent using a multimodal imaging system

Rouyan Chen, Robert McLaughlin, Jiawen Li, Christina Bursill, Lauren Sandeman, Joanne T. M. Tan, Victoria Nankivell, Gang Zheng, Peter Psaltis

Proceedings Volume 12819, 128190A (2024) https://doi.org/10.1117/12.3000277

KEYWORDS: Imaging systems, Fluorescence, Atherosclerosis, Nanoparticles, Optical coherence tomography, Multimodal imaging, Contrast agents, Signal detection, Fluorescence spectroscopy, Biological imaging

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Proceedings Article | 17 March 2023 Open Access

Porphysome nanotechnology: from discovery toward first-in-patients

Gang Zheng

Proceedings Volume PC12361, PC1236101 (2023) https://doi.org/10.1117/12.2674092

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Proceedings Article | 14 March 2023 Presentation + Paper

Use of an indocyanine green nano-emulsion for the treatment of cutaneous melanoma by photothermal therapy

Letícia Martinelli, Gabriel Jasinevicius, Lilian Tan Moriyama, Hilde Buzzá, Juan Chen, Gang Zheng, Cristina Kurachi

Proceedings Volume 12352, 1235207 (2023) https://doi.org/10.1117/12.2649420

KEYWORDS: Tumors, Melanoma, Animals, Molecules, Indocyanine green, Laser irradiation, Tissues, Skin cancer

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Proceedings Article | 4 March 2022 Presentation + Paper

Measurement of intact and dissociated porphyrin-lipid nanoparticle concentration in tissue using diffuse reflectance and fluorescence spectroscopy

Theo Husby, Michael Valic, Gang Zheng, Brian Wilson, Robert Weersink

Proceedings Volume 11938, 1193806 (2022) https://doi.org/10.1117/12.2609870

KEYWORDS: Luminescence, Absorption, Reflectivity, Diffuse reflectance spectroscopy, Positron emission tomography, Scattering, Tumors, Tissue optics, Light emitting diodes

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Proceedings Article | 7 August 2019 Paper

Long-circulating prostate-specific membrane antigen-targeted NIR phototheranostic agent

Kara Harmatys, Juan Chen, Martin Pomper, Gang Zheng, Marta Overchuk, Martha Damen

Proceedings Volume 11070, 110704J (2019) https://doi.org/10.1117/12.2525622

KEYWORDS: Tumors, Photodynamic therapy, Near infrared, Plasma, Absorption, In vivo imaging, Tissues, Cancer, Prostate cancer

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Proceedings Article | 27 February 2019 Paper

Pre-clinical validation of transrectal diffuse optical tomography for monitoring photocoagulation progression during photothermal therapy of prostate cancer

Runjie Bill Shi, Celina Li, Carl Fisher, Jie He, Brian Wilson, Gang Zheng, Robert Weersink

Proceedings Volume 10871, 1087115 (2019) https://doi.org/10.1117/12.2509059

KEYWORDS: Diffuse optical tomography, Prostate, In vivo imaging, Reflectivity, Laser coagulation, Sensors, Tissue optics, Optical properties, Magnetic resonance imaging, Thermometry, Signal detection

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Proceedings Article | 26 February 2019 Presentation + Paper

Assessment of optical detection methods for coagulation-front monitoring photothermal therapy of prostate cancer

Michael Valic, Robert Weersink, Carl Fisher, Alexander Gregor, Alyssa Goldstein, Juan Chen, Rosanna Chan, Gang Zheng, Brian Wilson, Liang Lim

Proceedings Volume 10852, 1085209 (2019) https://doi.org/10.1117/12.2509004

KEYWORDS: Prostate, Magnetic resonance imaging, Tissues, In vivo imaging, Tissue optics, Prostate cancer, Optical fibers, Thermometry, Laser therapeutics

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SPIE Journal Paper | 13 July 2017 Open Access

Can photoacoustic imaging quantify surface-localized J-aggregating nanoparticles?

Liang Lim, Robert Mastragostino, Kenneth Ng, Gang Zheng, Brian Wilson

JBO, Vol. 22, Issue 07, 076008, (July 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.7.076008

KEYWORDS: Nanoparticles, Photoacoustic imaging, Tissue optics, Tissues, Absorption, Photoacoustic spectroscopy, Transducers, Optical testing, Scattering, Natural surfaces

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SPIE Journal Paper | 23 August 2016 Open Access

Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study

Christina MacLaughlin, Lili Ding, Cheng Jin, Pingjiang Cao, Iram Siddiqui, David Hwang, Juan Chen, Brian Wilson, Gang Zheng, David Hedley

JBO, Vol. 21, Issue 08, 084002, (August 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.8.084002

KEYWORDS: Tumors, Tissues, Pancreas, Luminescence, Nanoparticles, Cancer, Laser irradiation, Tumor growth modeling, Pancreatic cancer, Temperature metrology

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Proceedings Article | 4 March 2016 Presentation + Paper

Porphyrin lipid nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model

Lili Ding, Cheng Jin, Pingjiang Cao, Juan Chen, Brian Wilson, Gang Zheng, David Hedley, Christina MacLaughlin, Iram Siddiqui, David Hwang

Proceedings Volume 9696, 96960F (2016) https://doi.org/10.1117/12.2214882

KEYWORDS: Nanoparticles, Pancreas, Tumor growth modeling, Luminescence, Pancreatic cancer, Tissues, Laser therapeutics, Cancer, Laser ablation, In vivo imaging, Tumors, Laser irradiation, Tissue optics

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Proceedings Article | 3 March 2014 Paper

Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic and fluorescence imaging

Elizabeth Huynh, Gang Zheng

Proceedings Volume 8943, 89435O (2014) https://doi.org/10.1117/12.2038010

KEYWORDS: Luminescence, Ultrasonography, Photoacoustic spectroscopy, Photoacoustic imaging, Multimodal imaging, Image filtering, Transducers, Magnetic resonance imaging, Nuclear imaging, Optical properties

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SPIE Journal Paper | 6 January 2014 Open Access

Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging

Mansik Jeon, Wentao Song, Elizabeth Huynh, Jungho Kim, Jeesu Kim, Brandon Helfield, Benjamin Leung, David Geortz, Gang Zheng, Jungtaek Oh, Jonathan Lovell, Chulhong Kim

JBO, Vol. 19, Issue 01, 016005, (January 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.1.016005

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Imaging systems, Absorption, Photoacoustic imaging, Magnesium, Transducers, Signal attenuation, Ultrasonics, Acoustics

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Proceedings Article | 15 June 2011 Paper

Lung cancer targeted Raman active phospholipid gold nanoparticles for ultrasensitive and specific molecular imaging and detection

Benjamin M. Scott, Brian Wilson, Gang Zheng, Natalie C. Tam

Proceedings Volume 8090, 80900A (2011) https://doi.org/10.1117/12.889893

KEYWORDS: Raman spectroscopy, Gold, Lung cancer, Surface enhanced Raman spectroscopy, Nanoparticles, Lung, Molecular imaging, Confocal microscopy, Transmission electron microscopy, Cancer

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Proceedings Article | 25 February 2009 Paper

Real-time optical imaging of the interaction of epidermal growth factor and its receptor in living cells

Liang Wang, Shaoqun Zeng, Qiaoya Lin, Zhihong Zhang, Gang Zheng

Proceedings Volume 7178, 71780P (2009) https://doi.org/10.1117/12.811372

KEYWORDS: Fluorescence resonance energy transfer, Receptors, Green fluorescent protein, Signal detection, Visualization, Optical imaging, Proteins, Molecules, Bandpass filters, Cancer

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Proceedings Article | 11 July 2007 Paper

New linker design for biomarker-triggered photodynamic molecular beacons

Juan Chen, Michael Warren, Klara Stefflova, Pui-Chi Lo, Gang Zheng, Brian Wilson, Jonathan Cheng

Proceedings Volume 6626, 662603 (2007) https://doi.org/10.1117/12.728395

KEYWORDS: Picosecond phenomena, Photodynamic therapy, Tumors, Luminescence, Oxygen, Cancer, Proteins, Molecules, Chemistry, Oncology

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Proceedings Article | 11 July 2007 Paper

Functionalizing low-density lipoprotein nanoparticles for in vivo near-infrared optical imaging of cancer

Weiguo Cao, Juan Chen, Gang Zheng, Hui Li, Ian Corbin

Proceedings Volume 6626, 66260B (2007) https://doi.org/10.1117/12.728427

KEYWORDS: Tumors, Proteins, In vivo imaging, Cancer, Nanoparticles, Particles, Imaging systems, Receptors, Luminescence, Optical imaging

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Proceedings Article | 13 February 2007 Paper

Rational design of a receptor-targeted photodynamic molecular beacon for the multilevel control of singlet oxygen production and PDT activity in cancer cells

Gang Zheng, Juan Chen, Mike Warren, Klara Stefflova, Brian Wilson, Jiachuan Bu

Proceedings Volume 6449, 644906 (2007) https://doi.org/10.1117/12.699754

KEYWORDS: Photodynamic therapy, Cancer, Picosecond phenomena, Luminescence, Tumors, Oxygen, Tissues, Receptors, Confocal microscopy, In vivo imaging

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SPIE Journal Paper | 1 July 2005 Open Access

High payload delivery of optical imaging and photodynamic therapy agents to tumors using phthalocyanine-reconstituted low-density lipoprotein nanoparticles

Hui Li, Diane Marotta, Soungkyoo Kim, Theresa Busch, E. Paul Wileyto, Gang Zheng

JBO, Vol. 10, Issue 04, 041203, (July 2005) https://doi.org/10.1117/12.10.1117/1.2011429

KEYWORDS: Photodynamic therapy, Proteins, Tumors, Particles, Optical imaging, Confocal microscopy, Picosecond phenomena, Silicon, Nanoparticles, Receptors

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Proceedings Article | 18 January 2005 Paper

Molecular beacon-based photodynamic therapy

Hui Li, Juan Chen, Gang Zheng, Diane Marotta, Jerry Glickson, Soungkyoo Kim, Britton Chance, Klara Stefflova

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.573915

KEYWORDS: Photodynamic therapy, Luminescence, Picosecond phenomena, Oxygen, Quenching (fluorescence), Molecules, Absorption, Cancer, Energy transfer, Tumors

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Proceedings Article | 18 January 2005 Paper

Phthalocyanine-labeled LDL for tumor imaging and photodynamic therapy

Jerry Glickson, Britton Chance, Hui Li, Theresa Busch, Diane Marotta, Soungkyoo Kim, Gang Zheng

Proceedings Volume 5630, (2005) https://doi.org/10.1117/12.573912

KEYWORDS: Photodynamic therapy, Tumors, Picosecond phenomena, Silicon, Confocal microscopy, Proteins, Cancer, Near infrared, In vitro testing, Receptors

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Proceedings Article | 20 August 2004 Paper

Imaging of tumor hypermetabolism with near-infrared fluorescence contrast agents

Samuel Achilefu, Zhihong Zhang, Yu Chen, Gang Zheng, Britton Chance, Xavier Intes, Dana Blessington

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578379

KEYWORDS: Tumors, Luminescence, Imaging systems, Tissues, Photons, Breast, In vivo imaging, Phased arrays, Signal detection, Near infrared

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SPIE Journal Paper | 1 July 2004 Open Access

Redox ratio of mitochondria as an indicator for the response of photodynamic therapy

Zhihong Zhang, Dana Blessington, Hui Li, Theresa Busch, Jerry Glickson, Qingming Luo, Britton Chance, Gang Zheng

JBO, Vol. 9, Issue 04, (July 2004) https://doi.org/10.1117/12.10.1117/1.1760759

KEYWORDS: Tumors, Photodynamic therapy, Luminescence, Control systems, Flavoproteins, Oxygen, Tissues, Photography, Radiology, Tissue optics

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Proceedings Article | 14 June 2004 Paper

NIR optical probes targeting glucose transporters

Britton Chance, Hui Li, David Benaron, Gang Zheng, Jerry Glickson, Zhihong Zhang, Juan Chen, Min Zhang

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.533148

KEYWORDS: Tumors, Near infrared, Cancer, In vivo imaging, Glucose, Confocal microscopy, Luminescence, Imaging systems, Liver, Tissues

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Proceedings Article | 8 December 2003 Paper

Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager

Dana Blessington, Qingming Luo, Zhihong Zhang, Britton Chance, Gang Zheng

Proceedings Volume 5254, (2003) https://doi.org/10.1117/12.546193

KEYWORDS: Liver, Tissues, Tumors, Signal detection, Near infrared, Tissue optics, Luminescence, Glucose, Brain, Optical fibers

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Proceedings Article | 29 July 2003 Paper

Detection and imaging of the reconstituted pyropheophorbide-cholesterol oleate labeled low-density lipoprotein in the HepG2 tumor

Min Zhang, Britton Chance, Zhihong Zhang, Hui Li, Gang Zheng, Lanlan Zhou, Dana Blessington, Jerry Glickson

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478190

KEYWORDS: Tumors, Luminescence, Tissues, Blood vessels, Receptors, Signal detection, Imaging systems, Melanoma, Optical filters, Veins

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Proceedings Article | 29 July 2003 Paper

Determination of subsurface tumor localization in animal models with near-infrared (NIR) fluorescence imaging

Min Zhang, Gang Zheng, Samuel Achilefu, Yu Chen, Qian Liu, Chenpeng Mu, Britton Chance, Dana Blessington, Xavier Intes, Zhihong Zhang, Lanlan Zhou, Hui Li

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478187

KEYWORDS: Tumors, Luminescence, Animal model studies, Scattering, Near infrared, Phased arrays, In vivo imaging, Breast, Signal detection, Imaging systems

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Proceedings Article | 29 July 2003 Paper

Three-dimensional imaging of the metabolic state of c-MYC-induced mammary tumor with the cryo-imager

Qingming Luo, Min Zhang, Dana Blessington, Zhihong Zhang, Gang Zheng, Lewis Chodosh, Britton Chance, Qian Liu, Lanlan Zhou

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.503163

KEYWORDS: Tumors, 3D image processing, Glucose, Luminescence, Tissues, Signal detection, Tissue optics, Natural surfaces, Mode conditioning cables, Oxygen

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Proceedings Article | 15 April 1998 Paper

Rare-earth-doped polymers for optical amplification and lasing

Renyuan Gao, G. Zheng, Anthony Garito, C. Koeppen

Proceedings Volume 3280, (1998) https://doi.org/10.1117/12.305400

KEYWORDS: Polymers, Chromophores, Ions, Optical amplifiers, Optical properties, Doping, Numerical simulations, Fiber amplifiers, Oscillators, Absorption

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